BR112015023343A2 - método para preparar sovaprevir, método de preparar um composto da fórmula (c), método de preparação do composto f-2, composto, processo, método de preparação de uma forma amorfa pura de sovaprevir, e,forma cristalina de sovaprevir - Google Patents

método para preparar sovaprevir, método de preparar um composto da fórmula (c), método de preparação do composto f-2, composto, processo, método de preparação de uma forma amorfa pura de sovaprevir, e,forma cristalina de sovaprevir

Info

Publication number
BR112015023343A2
BR112015023343A2 BR112015023343A BR112015023343A BR112015023343A2 BR 112015023343 A2 BR112015023343 A2 BR 112015023343A2 BR 112015023343 A BR112015023343 A BR 112015023343A BR 112015023343 A BR112015023343 A BR 112015023343A BR 112015023343 A2 BR112015023343 A2 BR 112015023343A2
Authority
BR
Brazil
Prior art keywords
preparing
sovaprevir
compound
crystalline form
formula
Prior art date
Application number
BR112015023343A
Other languages
English (en)
Inventor
Hashimoto Akihiro
Phadke Avinash
Gadhachanda Venkat
Original Assignee
Achillion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achillion Pharmaceuticals Inc filed Critical Achillion Pharmaceuticals Inc
Publication of BR112015023343A2 publication Critical patent/BR112015023343A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

resumo método para preparar sovaprevir, método de preparar um composto da fórmula (c), método de preparação do composto f-2, composto, processo, método de preparação de uma forma amorfa pura de sovaprevir, e,forma cristalina de sovaprevir a divulgação inclui novos processos para a produção de sovaprevir compreendendo a adição do composto e a f-1 para fornecer sovaprevir. a divulgação inclui ainda intermediários úteis para a produção de sovaprevir. a divulgação também inclui uma nova forma cristalina de sovaprevir, forma f, e um método para a preparação de sovaprevir amorfo seco por pulverização a partir da forma cristalina f. 1/1
BR112015023343A 2013-03-14 2014-03-14 método para preparar sovaprevir, método de preparar um composto da fórmula (c), método de preparação do composto f-2, composto, processo, método de preparação de uma forma amorfa pura de sovaprevir, e,forma cristalina de sovaprevir BR112015023343A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361784182P 2013-03-14 2013-03-14
PCT/US2014/028278 WO2014152928A2 (en) 2013-03-14 2014-03-14 Novel processes for producing sovaprevir

Publications (1)

Publication Number Publication Date
BR112015023343A2 true BR112015023343A2 (pt) 2017-07-18

Family

ID=50680160

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015023343A BR112015023343A2 (pt) 2013-03-14 2014-03-14 método para preparar sovaprevir, método de preparar um composto da fórmula (c), método de preparação do composto f-2, composto, processo, método de preparação de uma forma amorfa pura de sovaprevir, e,forma cristalina de sovaprevir

Country Status (13)

Country Link
US (2) US9115175B2 (pt)
EP (1) EP2970195B1 (pt)
JP (1) JP2016515139A (pt)
KR (1) KR20160005334A (pt)
CN (1) CN105408317A (pt)
AU (1) AU2014236502A1 (pt)
BR (1) BR112015023343A2 (pt)
CA (1) CA2905433A1 (pt)
EA (1) EA201591722A1 (pt)
IL (1) IL241287A0 (pt)
PH (1) PH12015502121A1 (pt)
SG (1) SG11201507469RA (pt)
WO (1) WO2014152928A2 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008008502A1 (en) 2006-07-13 2008-01-17 Achillion Pharmaceuticals, Inc. 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
CN109562113A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的螺环降解决定子体
WO2017197055A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation

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Also Published As

Publication number Publication date
SG11201507469RA (en) 2015-10-29
CN105408317A (zh) 2016-03-16
EA201591722A1 (ru) 2016-02-29
US9481708B2 (en) 2016-11-01
CA2905433A1 (en) 2014-09-25
AU2014236502A1 (en) 2015-10-01
EP2970195B1 (en) 2017-08-02
WO2014152928A3 (en) 2015-01-08
PH12015502121A1 (en) 2016-01-25
JP2016515139A (ja) 2016-05-26
US20150322109A1 (en) 2015-11-12
EP2970195A2 (en) 2016-01-20
US9115175B2 (en) 2015-08-25
KR20160005334A (ko) 2016-01-14
US20140275480A1 (en) 2014-09-18
IL241287A0 (en) 2015-11-30
WO2014152928A2 (en) 2014-09-25

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]