AR085291A1 - Metodos para sintetizar derivados del precursor z de molibdopterina - Google Patents
Metodos para sintetizar derivados del precursor z de molibdopterinaInfo
- Publication number
- AR085291A1 AR085291A1 ARP120100560A ARP120100560A AR085291A1 AR 085291 A1 AR085291 A1 AR 085291A1 AR P120100560 A ARP120100560 A AR P120100560A AR P120100560 A ARP120100560 A AR P120100560A AR 085291 A1 AR085291 A1 AR 085291A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- prepare
- molibdopterine
- synthetizing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000002243 precursor Substances 0.000 title 1
- 230000003407 synthetizing effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 25
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 230000001590 oxidative effect Effects 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000001488 molybdenum cofactor deficiency Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
Abstract
Estos compuestos son de utilidad para tratar trastornos asociados con deficiencia de cofactor de molibdeno. Composiciones farmacéuticas e intermediarios.Reivindicación 1: Un proceso para preparar un compuesto de la fórmula (1) o una de sus sales farmacéuticamente aceptables, donde el proceso comprende: (a) hacer reaccionar un compuesto de la fórmula (2) con un compuesto de la fórmula (3) para producir un compuesto de la fórmula (4), en donde: cada R1 es, de modo independiente, H o un grupo protector; (b) proteger selectivamente el compuesto de la fórmula (4) para preparar un compuesto de la fórmula (5); (c) fosforilar el compuesto de la fórmula (5) para preparar un compuesto de la fórmula (6); (d) oxidar el compuesto de la fórmula (6) para preparar un compuesto de la fórmula (7); y (e) desproteger el compuesto de la fórmula (7) para preparar el compuesto de la fórmula (1). Reivindicación 38: Un proceso para preparar un compuesto de la fórmula (8) o una de sus formas salinas farmacéuticamente aceptables, donde el proceso comprende: (a) hacer reaccionar un compuesto de la fórmula (2) con un compuesto de la fórmula (3) para producir un compuesto de la fórmula (4), en donde: cada R1 es, de modo independiente, H o un grupo protector; (b) proteger selectivamente el compuesto de la fórmula (4) para preparar un compuesto de la formula (5); (c) fosforilar el compuesto de la fórmula (5) para preparar un compuesto de la fórmula (6); (d) oxidar el compuesto de la fórmula (6) para preparar un compuesto de la fórmula (9); y (e) desproteger el compuesto de la fórmula (9) para preparar el compuesto de la fórmula (8).
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161444389P | 2011-02-18 | 2011-02-18 | |
| US201161444280P | 2011-02-18 | 2011-02-18 | |
| US201161444399P | 2011-02-18 | 2011-02-18 | |
| US201161498808P | 2011-06-20 | 2011-06-20 | |
| US201161498801P | 2011-06-20 | 2011-06-20 | |
| US201261599314P | 2012-02-15 | 2012-02-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR085291A1 true AR085291A1 (es) | 2013-09-18 |
Family
ID=46672966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100560A AR085291A1 (es) | 2011-02-18 | 2012-02-17 | Metodos para sintetizar derivados del precursor z de molibdopterina |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9260462B2 (es) |
| EP (1) | EP2675278B1 (es) |
| JP (1) | JP5972911B2 (es) |
| KR (1) | KR20140007431A (es) |
| AR (1) | AR085291A1 (es) |
| AU (1) | AU2012219292B2 (es) |
| BR (1) | BR112013020864A2 (es) |
| CA (1) | CA2827679C (es) |
| CO (1) | CO7071121A2 (es) |
| EA (1) | EA201391206A1 (es) |
| ES (1) | ES2569252T3 (es) |
| IL (1) | IL227917A0 (es) |
| MX (1) | MX2013009501A (es) |
| SG (1) | SG192826A1 (es) |
| TW (1) | TW201241005A (es) |
| WO (1) | WO2012112922A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2675278B1 (en) | 2011-02-18 | 2016-02-17 | Alexion Pharma International SARL | Methods for synthesizing molybdopterin precursor z derivatives |
| ES2959188T3 (es) * | 2015-01-15 | 2024-02-21 | Mayo Found Medical Education & Res | Procedimientos de tratamiento de trastornos inflamatorios neurológicos |
| WO2017019532A1 (en) | 2015-07-24 | 2017-02-02 | Alexion Pharmaceuticals, Inc. | Precursor z (cpmp) to treat molybdenum cofactor deficiency type a |
| BR112018012914B1 (pt) | 2015-12-22 | 2023-04-18 | SHY Therapeutics LLC | Composto, uso de um composto e composição farmacêutica |
| SG11201911929XA (en) | 2017-06-21 | 2020-01-30 | SHY Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| WO2023227763A1 (en) | 2022-05-27 | 2023-11-30 | Arlanxeo Deutschland Gmbh | Rubber compounds of functionalized conjugated diene rubbers and silica fillers |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4713454A (en) | 1985-01-28 | 1987-12-15 | Shiratori Pharmaceutical Co., Ltd. | Preparation process of (6R)-tetrahydro-L-biopterin |
| CA2378687A1 (en) | 1999-06-18 | 2000-12-28 | Elitra Pharmaceuticals, Inc. | Nucleotide sequences of moraxella catarrhalis genome |
| CZ303572B6 (cs) | 2000-06-28 | 2012-12-12 | Smithkline Beecham P. L. C. | Jemne rozmelnený prostredek a zpusob jeho prípravy |
| US20030207430A1 (en) | 2001-03-01 | 2003-11-06 | Tang Y. Tom | Human enzyme molecules |
| DE102004004642A1 (de) | 2004-01-29 | 2006-04-27 | Schwarz, Guenter, Dr. | Produktion, Gewinnung und therapeutischer Einsatz des Molybdopterin-Derivats Precursor Z zur Therapie der Stoffwechselerkrankung humaner Molybdäncofaktor-Defizienz und anderer assoziierter Krankheiten |
| WO2007052308A2 (en) | 2005-11-03 | 2007-05-10 | Brain N' Beyond Biotech Pvt. Ltd. | Glyco-phosphorylated biologically active agents |
| JP2010515747A (ja) | 2007-01-12 | 2010-05-13 | ビオマリン プハルマセウトイカル インコーポレイテッド | テトラヒドロビオプテリンプロドラッグ |
| US7888506B2 (en) | 2007-01-26 | 2011-02-15 | Duquesne University Of The Holy Spirit | Composition, synthesis, and use of a new class of fluorophores |
| MX2010007452A (es) | 2008-01-07 | 2010-08-18 | Biomarin Pharm Inc | Metodo para sintetizar tetrahidrobiopterin. |
| JP5587213B2 (ja) | 2008-02-26 | 2014-09-10 | サンド・アクチエンゲゼルシヤフト | モルホリン誘導体の調製 |
| EP2675278B1 (en) | 2011-02-18 | 2016-02-17 | Alexion Pharma International SARL | Methods for synthesizing molybdopterin precursor z derivatives |
-
2012
- 2012-02-17 EP EP12747519.2A patent/EP2675278B1/en active Active
- 2012-02-17 KR KR1020137023985A patent/KR20140007431A/ko not_active Application Discontinuation
- 2012-02-17 CA CA2827679A patent/CA2827679C/en active Active
- 2012-02-17 MX MX2013009501A patent/MX2013009501A/es not_active Application Discontinuation
- 2012-02-17 BR BR112013020864A patent/BR112013020864A2/pt not_active IP Right Cessation
- 2012-02-17 AR ARP120100560A patent/AR085291A1/es unknown
- 2012-02-17 EA EA201391206A patent/EA201391206A1/ru unknown
- 2012-02-17 SG SG2013062591A patent/SG192826A1/en unknown
- 2012-02-17 WO PCT/US2012/025689 patent/WO2012112922A1/en active Application Filing
- 2012-02-17 ES ES12747519.2T patent/ES2569252T3/es active Active
- 2012-02-17 AU AU2012219292A patent/AU2012219292B2/en not_active Ceased
- 2012-02-17 JP JP2013554645A patent/JP5972911B2/ja not_active Expired - Fee Related
- 2012-02-17 TW TW101105390A patent/TW201241005A/zh unknown
- 2012-02-17 US US14/000,055 patent/US9260462B2/en active Active
-
2013
- 2013-08-11 IL IL227917A patent/IL227917A0/en unknown
- 2013-08-22 CO CO13199113A patent/CO7071121A2/es unknown
-
2014
- 2014-03-07 US US14/200,676 patent/US20140303367A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL227917A0 (en) | 2013-09-30 |
| ES2569252T3 (es) | 2016-05-09 |
| JP5972911B2 (ja) | 2016-08-17 |
| US20140303367A1 (en) | 2014-10-09 |
| SG192826A1 (en) | 2013-09-30 |
| US20140323726A1 (en) | 2014-10-30 |
| EP2675278B1 (en) | 2016-02-17 |
| US9260462B2 (en) | 2016-02-16 |
| AU2012219292B2 (en) | 2015-03-05 |
| EP2675278A1 (en) | 2013-12-25 |
| EA201391206A1 (ru) | 2014-02-28 |
| BR112013020864A2 (pt) | 2019-09-24 |
| CA2827679C (en) | 2020-06-02 |
| TW201241005A (en) | 2012-10-16 |
| NZ614009A (en) | 2014-08-29 |
| MX2013009501A (es) | 2014-02-03 |
| CA2827679A1 (en) | 2012-08-23 |
| CO7071121A2 (es) | 2014-09-30 |
| JP2014510054A (ja) | 2014-04-24 |
| KR20140007431A (ko) | 2014-01-17 |
| WO2012112922A1 (en) | 2012-08-23 |
| AU2012219292A1 (en) | 2013-03-14 |
| EP2675278A4 (en) | 2014-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |