BR112013020864A2 - métodos para sintetizar derivados de precursor z de molibdopterina - Google Patents
métodos para sintetizar derivados de precursor z de molibdopterinaInfo
- Publication number
- BR112013020864A2 BR112013020864A2 BR112013020864A BR112013020864A BR112013020864A2 BR 112013020864 A2 BR112013020864 A2 BR 112013020864A2 BR 112013020864 A BR112013020864 A BR 112013020864A BR 112013020864 A BR112013020864 A BR 112013020864A BR 112013020864 A2 BR112013020864 A2 BR 112013020864A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- formula
- molybdopterin
- synthesizing
- derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 108010046778 molybdenum cofactor Proteins 0.000 title abstract 2
- HPEUEJRPDGMIMY-IFQPEPLCSA-N molybdopterin Chemical compound O([C@H]1N2)[C@H](COP(O)(O)=O)C(S)=C(S)[C@@H]1NC1=C2N=C(N)NC1=O HPEUEJRPDGMIMY-IFQPEPLCSA-N 0.000 title abstract 2
- 239000002243 precursor Substances 0.000 title abstract 2
- 230000002194 synthesizing effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000010189 synthetic method Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000001488 molybdenum cofactor deficiency Diseases 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
Abstract
métodos para sintetizar derivados de precursor z de molibdopterina a presente invenção refere-se a métodos sintéticos para preparar um composto da fórmula (i): também providos aqui são métodos sintéticos para preparar um composto da fórmula (xiii): a descrição também provê intermediários úteis, derivados, profármacos, e sais, solvatos e hidratos farmaceuticamente aceitáveis dos compostos da fórmula (i) e fórmula (xiii). esses compostos são úteis para tratar doenças associadas com deficiência de cofator de molibdênio.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161444280P | 2011-02-18 | 2011-02-18 | |
US201161444399P | 2011-02-18 | 2011-02-18 | |
US201161444389P | 2011-02-18 | 2011-02-18 | |
US201161498801P | 2011-06-20 | 2011-06-20 | |
US201161498808P | 2011-06-20 | 2011-06-20 | |
US201261599314P | 2012-02-15 | 2012-02-15 | |
PCT/US2012/025689 WO2012112922A1 (en) | 2011-02-18 | 2012-02-17 | Methods for synthesizing molybdopterin precursor z derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013020864A2 true BR112013020864A2 (pt) | 2019-09-24 |
Family
ID=46672966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013020864A BR112013020864A2 (pt) | 2011-02-18 | 2012-02-17 | métodos para sintetizar derivados de precursor z de molibdopterina |
Country Status (16)
Country | Link |
---|---|
US (2) | US9260462B2 (pt) |
EP (1) | EP2675278B1 (pt) |
JP (1) | JP5972911B2 (pt) |
KR (1) | KR20140007431A (pt) |
AR (1) | AR085291A1 (pt) |
AU (1) | AU2012219292B2 (pt) |
BR (1) | BR112013020864A2 (pt) |
CA (1) | CA2827679C (pt) |
CO (1) | CO7071121A2 (pt) |
EA (1) | EA201391206A1 (pt) |
ES (1) | ES2569252T3 (pt) |
IL (1) | IL227917A0 (pt) |
MX (1) | MX2013009501A (pt) |
SG (1) | SG192826A1 (pt) |
TW (1) | TW201241005A (pt) |
WO (1) | WO2012112922A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG192826A1 (en) | 2011-02-18 | 2013-09-30 | Alexion Pharma Internat Sarl | Methods for synthesizing molybdopterin precursor z derivatives |
WO2016115473A1 (en) * | 2015-01-15 | 2016-07-21 | Mayo Foundation For Medical Education And Research | Methods of treating neurological inflammatory disorders |
WO2017019532A1 (en) | 2015-07-24 | 2017-02-02 | Alexion Pharmaceuticals, Inc. | Precursor z (cpmp) to treat molybdenum cofactor deficiency type a |
SG11201804901WA (en) | 2015-12-22 | 2018-07-30 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
CA3066939A1 (en) * | 2017-06-21 | 2018-12-27 | SHY Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
WO2023227763A1 (en) | 2022-05-27 | 2023-11-30 | Arlanxeo Deutschland Gmbh | Rubber compounds of functionalized conjugated diene rubbers and silica fillers |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4713454A (en) | 1985-01-28 | 1987-12-15 | Shiratori Pharmaceutical Co., Ltd. | Preparation process of (6R)-tetrahydro-L-biopterin |
EP1218512A2 (en) * | 1999-06-18 | 2002-07-03 | Elitra Pharmaceuticals, Inc. | Nucleotide sequences of moraxella catarrhalis genome |
IL153231A0 (en) | 2000-06-28 | 2003-07-06 | Smithkline Beecham Plc | Wet milling process |
US20030207430A1 (en) * | 2001-03-01 | 2003-11-06 | Tang Y. Tom | Human enzyme molecules |
DE102004004642A1 (de) * | 2004-01-29 | 2006-04-27 | Schwarz, Guenter, Dr. | Produktion, Gewinnung und therapeutischer Einsatz des Molybdopterin-Derivats Precursor Z zur Therapie der Stoffwechselerkrankung humaner Molybdäncofaktor-Defizienz und anderer assoziierter Krankheiten |
WO2007052308A2 (en) | 2005-11-03 | 2007-05-10 | Brain N' Beyond Biotech Pvt. Ltd. | Glyco-phosphorylated biologically active agents |
AU2008206486C1 (en) | 2007-01-12 | 2013-09-26 | Biomarin Pharmaceutical Inc. | Tetrahydrobiopterin prodrugs |
US7888506B2 (en) * | 2007-01-26 | 2011-02-15 | Duquesne University Of The Holy Spirit | Composition, synthesis, and use of a new class of fluorophores |
JP2011508781A (ja) | 2008-01-07 | 2011-03-17 | ビオマリン プハルマセウトイカル インコーポレイテッド | テトラヒドロビオプテリンの合成方法 |
US20110009629A1 (en) * | 2008-02-26 | 2011-01-13 | Sandoz Ag | Preparation of morpholine derivatives |
SG192826A1 (en) | 2011-02-18 | 2013-09-30 | Alexion Pharma Internat Sarl | Methods for synthesizing molybdopterin precursor z derivatives |
-
2012
- 2012-02-17 SG SG2013062591A patent/SG192826A1/en unknown
- 2012-02-17 EP EP12747519.2A patent/EP2675278B1/en active Active
- 2012-02-17 TW TW101105390A patent/TW201241005A/zh unknown
- 2012-02-17 WO PCT/US2012/025689 patent/WO2012112922A1/en active Application Filing
- 2012-02-17 KR KR1020137023985A patent/KR20140007431A/ko not_active Application Discontinuation
- 2012-02-17 EA EA201391206A patent/EA201391206A1/ru unknown
- 2012-02-17 ES ES12747519.2T patent/ES2569252T3/es active Active
- 2012-02-17 BR BR112013020864A patent/BR112013020864A2/pt not_active IP Right Cessation
- 2012-02-17 MX MX2013009501A patent/MX2013009501A/es not_active Application Discontinuation
- 2012-02-17 AU AU2012219292A patent/AU2012219292B2/en not_active Ceased
- 2012-02-17 CA CA2827679A patent/CA2827679C/en active Active
- 2012-02-17 US US14/000,055 patent/US9260462B2/en active Active
- 2012-02-17 JP JP2013554645A patent/JP5972911B2/ja not_active Expired - Fee Related
- 2012-02-17 AR ARP120100560A patent/AR085291A1/es unknown
-
2013
- 2013-08-11 IL IL227917A patent/IL227917A0/en unknown
- 2013-08-22 CO CO13199113A patent/CO7071121A2/es unknown
-
2014
- 2014-03-07 US US14/200,676 patent/US20140303367A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2675278A1 (en) | 2013-12-25 |
EP2675278A4 (en) | 2014-08-20 |
CA2827679A1 (en) | 2012-08-23 |
US20140303367A1 (en) | 2014-10-09 |
AU2012219292B2 (en) | 2015-03-05 |
ES2569252T3 (es) | 2016-05-09 |
AU2012219292A1 (en) | 2013-03-14 |
IL227917A0 (en) | 2013-09-30 |
TW201241005A (en) | 2012-10-16 |
CO7071121A2 (es) | 2014-09-30 |
AR085291A1 (es) | 2013-09-18 |
JP2014510054A (ja) | 2014-04-24 |
WO2012112922A1 (en) | 2012-08-23 |
MX2013009501A (es) | 2014-02-03 |
US9260462B2 (en) | 2016-02-16 |
EA201391206A1 (ru) | 2014-02-28 |
CA2827679C (en) | 2020-06-02 |
NZ614009A (en) | 2014-08-29 |
SG192826A1 (en) | 2013-09-30 |
EP2675278B1 (en) | 2016-02-17 |
US20140323726A1 (en) | 2014-10-30 |
KR20140007431A (ko) | 2014-01-17 |
JP5972911B2 (ja) | 2016-08-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1119731T1 (el) | Διαδικασια για την παρασκευη παραγωγων χολικου οξεος | |
UY33227A (es) | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 | |
AU2012313888A8 (en) | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH | |
UY38712A (es) | Lactamas fusionadas de arilo y heteroarilo | |
CO6710897A2 (es) | Derivados de poperdinona como inhibidores mdm2 para el tratamiento del cáncer | |
BR112013020864A2 (pt) | métodos para sintetizar derivados de precursor z de molibdopterina | |
EA201201378A1 (ru) | Определенные аминопиримидины, композиции на их основе и способы их использования | |
UA111626C2 (uk) | Похідні дигідрохінолін-2-ону | |
EA201270752A1 (ru) | Ингибиторы киназы и способ лечения злокачественной опухоли с их помощью | |
MY164776A (en) | Heterocyclic compound | |
EA201590979A1 (ru) | Способы и промежуточные химические соединения для получения фармацевтических средств | |
EA201491149A1 (ru) | Пиразолопиридиновые производные, способы их получения и их терапевтическое применение | |
MX338551B (es) | Nuevos compuestos de piridina fusionada como inhibidores de caseina quinasa. | |
BR112012029647A2 (pt) | novos derivados de pirimidinas | |
EA201490754A1 (ru) | Производные карбамата/мочевины, содержащие пиперидиновые и пиперазиновые кольца, в качестве ингибиторов н3 рецептора | |
IN2013MN02170A (pt) | ||
MY169028A (en) | Process for making hydroxylated cyclopentylpyrimidine compounds | |
CY1117087T1 (el) | Διαδικασια για την παρασκευη εστερων (5-φθορο-2-μεθυλο-3-κινολιν-2-υλμεθυλ-ινδoλ-1-υλ)- οξικου οξεος | |
MX2013000009A (es) | Procedimiento de preparacion de la sal de l-arginina de perindoprilo. | |
ECSP13012914A (es) | Síntesis de derivados de 2-carboxamida-cicloamino-urea | |
IN2014DN06192A (pt) | ||
UY32748A (es) | 2-carboxamida-cicloamino-ureas | |
EA201001566A1 (ru) | Новый класс спиропиперидинов для лечения нейродегенеративных заболеваний | |
UY32747A (es) | 2-carboxamida-cicloamino-ureas sustituidas | |
ECSP13012548A (es) | Inhibidores de oxadiazol de la producción de leucotrienos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |