CO7071121A2 - Métodos para sintetizar derivados del precusor z de molibdopterina - Google Patents
Métodos para sintetizar derivados del precusor z de molibdopterinaInfo
- Publication number
- CO7071121A2 CO7071121A2 CO13199113A CO13199113A CO7071121A2 CO 7071121 A2 CO7071121 A2 CO 7071121A2 CO 13199113 A CO13199113 A CO 13199113A CO 13199113 A CO13199113 A CO 13199113A CO 7071121 A2 CO7071121 A2 CO 7071121A2
- Authority
- CO
- Colombia
- Prior art keywords
- molybdopterin
- precusor
- synthesizing
- derivatives
- methods
- Prior art date
Links
- 108010046778 molybdenum cofactor Proteins 0.000 title 1
- HPEUEJRPDGMIMY-IFQPEPLCSA-N molybdopterin Chemical compound O([C@H]1N2)[C@H](COP(O)(O)=O)C(S)=C(S)[C@@H]1NC1=C2N=C(N)NC1=O HPEUEJRPDGMIMY-IFQPEPLCSA-N 0.000 title 1
- 230000002194 synthesizing effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161444389P | 2011-02-18 | 2011-02-18 | |
US201161444280P | 2011-02-18 | 2011-02-18 | |
US201161444399P | 2011-02-18 | 2011-02-18 | |
US201161498801P | 2011-06-20 | 2011-06-20 | |
US201161498808P | 2011-06-20 | 2011-06-20 | |
US201261599314P | 2012-02-15 | 2012-02-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO7071121A2 true CO7071121A2 (es) | 2014-09-30 |
Family
ID=46672966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13199113A CO7071121A2 (es) | 2011-02-18 | 2013-08-22 | Métodos para sintetizar derivados del precusor z de molibdopterina |
Country Status (16)
Country | Link |
---|---|
US (2) | US9260462B2 (es) |
EP (1) | EP2675278B1 (es) |
JP (1) | JP5972911B2 (es) |
KR (1) | KR20140007431A (es) |
AR (1) | AR085291A1 (es) |
AU (1) | AU2012219292B2 (es) |
BR (1) | BR112013020864A2 (es) |
CA (1) | CA2827679C (es) |
CO (1) | CO7071121A2 (es) |
EA (1) | EA201391206A1 (es) |
ES (1) | ES2569252T3 (es) |
IL (1) | IL227917A0 (es) |
MX (1) | MX2013009501A (es) |
SG (1) | SG192826A1 (es) |
TW (1) | TW201241005A (es) |
WO (1) | WO2012112922A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG192826A1 (en) | 2011-02-18 | 2013-09-30 | Alexion Pharma Internat Sarl | Methods for synthesizing molybdopterin precursor z derivatives |
EP3245215B9 (en) * | 2015-01-15 | 2023-10-04 | Mayo Foundation for Medical Education and Research | Methods of treating neurological inflammatory disorders |
WO2017019532A1 (en) | 2015-07-24 | 2017-02-02 | Alexion Pharmaceuticals, Inc. | Precursor z (cpmp) to treat molybdenum cofactor deficiency type a |
WO2017112777A1 (en) | 2015-12-22 | 2017-06-29 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
KR20200041294A (ko) | 2017-06-21 | 2020-04-21 | 샤이 테라퓨틱스 엘엘씨 | 암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물 |
WO2023227763A1 (en) | 2022-05-27 | 2023-11-30 | Arlanxeo Deutschland Gmbh | Rubber compounds of functionalized conjugated diene rubbers and silica fillers |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
CA1262347A (en) | 1985-01-28 | 1989-10-17 | Suntory Limited | Preparation process of (6r)-tetrahydro-l-biopterin |
US6632636B1 (en) * | 1999-06-18 | 2003-10-14 | Elitra Pharmaceuticals Inc. | Nucleic acids encoding 3-ketoacyl-ACP reductase from Moraxella catarrahalis |
AU1560802A (en) | 2000-06-28 | 2002-01-08 | Smithkline Beecham Plc | Wet milling process |
US20030207430A1 (en) * | 2001-03-01 | 2003-11-06 | Tang Y. Tom | Human enzyme molecules |
DE102004004642A1 (de) * | 2004-01-29 | 2006-04-27 | Schwarz, Guenter, Dr. | Produktion, Gewinnung und therapeutischer Einsatz des Molybdopterin-Derivats Precursor Z zur Therapie der Stoffwechselerkrankung humaner Molybdäncofaktor-Defizienz und anderer assoziierter Krankheiten |
WO2007052308A2 (en) | 2005-11-03 | 2007-05-10 | Brain N' Beyond Biotech Pvt. Ltd. | Glyco-phosphorylated biologically active agents |
EP2114944A2 (en) | 2007-01-12 | 2009-11-11 | BioMarin Pharmaceutical Inc. | Tetrahydrobiopterin prodrugs |
US7888506B2 (en) * | 2007-01-26 | 2011-02-15 | Duquesne University Of The Holy Spirit | Composition, synthesis, and use of a new class of fluorophores |
CN101959891A (zh) | 2008-01-07 | 2011-01-26 | 生物马林药物股份有限公司 | 合成四氢生物蝶呤的方法 |
CA2715781C (en) * | 2008-02-26 | 2016-06-28 | Sandoz Ag | Preparation of morpholine derivatives |
SG192826A1 (en) | 2011-02-18 | 2013-09-30 | Alexion Pharma Internat Sarl | Methods for synthesizing molybdopterin precursor z derivatives |
-
2012
- 2012-02-17 SG SG2013062591A patent/SG192826A1/en unknown
- 2012-02-17 AR ARP120100560A patent/AR085291A1/es unknown
- 2012-02-17 EA EA201391206A patent/EA201391206A1/ru unknown
- 2012-02-17 ES ES12747519.2T patent/ES2569252T3/es active Active
- 2012-02-17 US US14/000,055 patent/US9260462B2/en active Active
- 2012-02-17 WO PCT/US2012/025689 patent/WO2012112922A1/en active Application Filing
- 2012-02-17 BR BR112013020864A patent/BR112013020864A2/pt not_active IP Right Cessation
- 2012-02-17 JP JP2013554645A patent/JP5972911B2/ja not_active Expired - Fee Related
- 2012-02-17 MX MX2013009501A patent/MX2013009501A/es not_active Application Discontinuation
- 2012-02-17 TW TW101105390A patent/TW201241005A/zh unknown
- 2012-02-17 AU AU2012219292A patent/AU2012219292B2/en not_active Ceased
- 2012-02-17 EP EP12747519.2A patent/EP2675278B1/en active Active
- 2012-02-17 KR KR1020137023985A patent/KR20140007431A/ko not_active Application Discontinuation
- 2012-02-17 CA CA2827679A patent/CA2827679C/en active Active
-
2013
- 2013-08-11 IL IL227917A patent/IL227917A0/en unknown
- 2013-08-22 CO CO13199113A patent/CO7071121A2/es unknown
-
2014
- 2014-03-07 US US14/200,676 patent/US20140303367A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2014510054A (ja) | 2014-04-24 |
NZ614009A (en) | 2014-08-29 |
US20140323726A1 (en) | 2014-10-30 |
TW201241005A (en) | 2012-10-16 |
EP2675278A4 (en) | 2014-08-20 |
EP2675278A1 (en) | 2013-12-25 |
CA2827679A1 (en) | 2012-08-23 |
US20140303367A1 (en) | 2014-10-09 |
ES2569252T3 (es) | 2016-05-09 |
AU2012219292A1 (en) | 2013-03-14 |
JP5972911B2 (ja) | 2016-08-17 |
EP2675278B1 (en) | 2016-02-17 |
IL227917A0 (en) | 2013-09-30 |
MX2013009501A (es) | 2014-02-03 |
AU2012219292B2 (en) | 2015-03-05 |
EA201391206A1 (ru) | 2014-02-28 |
SG192826A1 (en) | 2013-09-30 |
US9260462B2 (en) | 2016-02-16 |
KR20140007431A (ko) | 2014-01-17 |
WO2012112922A1 (en) | 2012-08-23 |
AR085291A1 (es) | 2013-09-18 |
CA2827679C (en) | 2020-06-02 |
BR112013020864A2 (pt) | 2019-09-24 |
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