MX2012014301A - Inhibidores macrociclicos de serina proteasa de hepatitis c. - Google Patents
Inhibidores macrociclicos de serina proteasa de hepatitis c.Info
- Publication number
- MX2012014301A MX2012014301A MX2012014301A MX2012014301A MX2012014301A MX 2012014301 A MX2012014301 A MX 2012014301A MX 2012014301 A MX2012014301 A MX 2012014301A MX 2012014301 A MX2012014301 A MX 2012014301A MX 2012014301 A MX2012014301 A MX 2012014301A
- Authority
- MX
- Mexico
- Prior art keywords
- protease inhibitors
- serine protease
- present
- hepatitis
- macrocyclic hepatitis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
La presente invención se refiere a nuevos compuestos macrocíclicos y a métodos para el tratamiento de una infección por el virus de la hepatitis C, en un sujeto que necesite tal tratamiento con dichos compuestos macrocíclicos. La presente invención además se refiere a composiciones farmacéuticas que comprenden los compuestos de la presente invención o sales, ésteres o profármacos farmacéuticamente aceptables de los mismos, en combinación con un vehículo o excipiente farmacéuticamente aceptable.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39710310P | 2010-06-07 | 2010-06-07 | |
PCT/US2011/039397 WO2011156337A2 (en) | 2010-06-07 | 2011-06-07 | Macrocyclic hepatitis c serine protease inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012014301A true MX2012014301A (es) | 2013-04-29 |
Family
ID=45098613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012014301A MX2012014301A (es) | 2010-06-07 | 2011-06-07 | Inhibidores macrociclicos de serina proteasa de hepatitis c. |
Country Status (8)
Country | Link |
---|---|
US (2) | US8748374B2 (es) |
EP (1) | EP2576564A4 (es) |
JP (1) | JP2013528217A (es) |
CN (1) | CN103025736B (es) |
CA (1) | CA2801584A1 (es) |
MX (1) | MX2012014301A (es) |
TW (1) | TW201211046A (es) |
WO (1) | WO2011156337A2 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2012014301A (es) | 2010-06-07 | 2013-04-29 | Enanta Pharm Inc | Inhibidores macrociclicos de serina proteasa de hepatitis c. |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
MA37992B1 (fr) | 2012-10-19 | 2018-09-28 | Bristol Myers Squibb Co | Composes inhibiteurs de protéase ns3 pour une utilisation dans le traitement de l’infection par le virus de l'hépatite c. |
US9334279B2 (en) | 2012-11-02 | 2016-05-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2914613B1 (en) | 2012-11-02 | 2017-11-22 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2914614B1 (en) | 2012-11-05 | 2017-08-16 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US9580463B2 (en) | 2013-03-07 | 2017-02-28 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9617310B2 (en) | 2013-03-15 | 2017-04-11 | Gilead Sciences, Inc. | Inhibitors of hepatitis C virus |
CN104163851B (zh) * | 2013-05-20 | 2019-03-05 | 湘北威尔曼制药股份有限公司 | 氟代的α-羰基类HCV NS3/4A丝氨酸蛋白酶抑制剂 |
JP6762873B2 (ja) | 2013-09-11 | 2020-09-30 | エモリー・ユニバーシテイ | ヌクレオチドおよびヌクレオシド組成物ならびにこれらに関連する使用 |
WO2017189978A1 (en) | 2016-04-28 | 2017-11-02 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
US11472778B2 (en) * | 2017-06-20 | 2022-10-18 | University Of Massachusetts | Hepatitis C virus NS3/4A protease inhibitors |
US11834515B2 (en) | 2017-10-11 | 2023-12-05 | Cornell University | Macrocyclic compounds as proteasome inhibitors |
CN110981820B (zh) * | 2019-12-25 | 2023-05-19 | 上海彩迩文生化科技有限公司 | 一种酸性条件下合成喹喔啉-2-酮的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA02010375A (es) * | 2000-04-19 | 2003-04-25 | Schering Corp | Inhibidores macrociclicos de la ns3-serina proteasa del virus de la hepatitis c que comprenden porciones alquil y arilalanina p2. |
EP1590442A4 (en) * | 2003-02-07 | 2007-07-18 | Enanta Pharm Inc | MACROCYCLIC HEPATITIS C SERIN PROTEASE INHIBITORS |
US7176208B2 (en) * | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
US7125845B2 (en) | 2003-07-03 | 2006-10-24 | Enanta Pharmaceuticals, Inc. | Aza-peptide macrocyclic hepatitis C serine protease inhibitors |
GB0612423D0 (en) * | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
AR061629A1 (es) * | 2006-06-26 | 2008-09-10 | Enanta Pharm Inc | Quinoxalinil macrociclicos inhibidores de serina proteasa del virus de la hepatitis c. proceso de obtencion y composiciones farmaceuticas |
WO2009073719A1 (en) * | 2007-12-05 | 2009-06-11 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl derivatives |
JP2013505952A (ja) * | 2009-09-28 | 2013-02-21 | インターミューン・インコーポレーテッド | C型肝炎ウイルス複製の新しい大環状阻害剤 |
TW201119667A (en) * | 2009-10-19 | 2011-06-16 | Enanta Pharm Inc | Bismacrocyclic compounds as hepatitis C virus inhibitors |
MX2012014301A (es) | 2010-06-07 | 2013-04-29 | Enanta Pharm Inc | Inhibidores macrociclicos de serina proteasa de hepatitis c. |
CA2822556A1 (en) | 2010-12-30 | 2012-07-05 | Enanta Pharmaceuticals, Inc | Macrocyclic hepatitis c serine protease inhibitors |
-
2011
- 2011-06-07 MX MX2012014301A patent/MX2012014301A/es active IP Right Grant
- 2011-06-07 EP EP11792997.6A patent/EP2576564A4/en not_active Withdrawn
- 2011-06-07 WO PCT/US2011/039397 patent/WO2011156337A2/en active Application Filing
- 2011-06-07 CN CN201180038242.4A patent/CN103025736B/zh active Active
- 2011-06-07 US US13/154,721 patent/US8748374B2/en active Active
- 2011-06-07 CA CA2801584A patent/CA2801584A1/en not_active Abandoned
- 2011-06-07 TW TW100119863A patent/TW201211046A/zh unknown
- 2011-06-07 JP JP2013514287A patent/JP2013528217A/ja active Pending
-
2014
- 2014-06-09 US US14/299,095 patent/US9493506B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
TW201211046A (en) | 2012-03-16 |
CN103025736B (zh) | 2016-07-06 |
US8748374B2 (en) | 2014-06-10 |
JP2013528217A (ja) | 2013-07-08 |
CA2801584A1 (en) | 2011-12-15 |
WO2011156337A2 (en) | 2011-12-15 |
EP2576564A4 (en) | 2014-01-22 |
US9493506B2 (en) | 2016-11-15 |
US20140287992A1 (en) | 2014-09-25 |
WO2011156337A3 (en) | 2012-04-26 |
EP2576564A2 (en) | 2013-04-10 |
US20120101031A1 (en) | 2012-04-26 |
CN103025736A (zh) | 2013-04-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |