EP1128832A4 - Compounds, compositions and methods for treating or preventing viral infections and associated diseases - Google Patents

Compounds, compositions and methods for treating or preventing viral infections and associated diseases

Info

Publication number
EP1128832A4
EP1128832A4 EP99942288A EP99942288A EP1128832A4 EP 1128832 A4 EP1128832 A4 EP 1128832A4 EP 99942288 A EP99942288 A EP 99942288A EP 99942288 A EP99942288 A EP 99942288A EP 1128832 A4 EP1128832 A4 EP 1128832A4
Authority
EP
European Patent Office
Prior art keywords
compositions
treating
compounds
methods
viral infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99942288A
Other languages
German (de)
French (fr)
Other versions
EP1128832A1 (en
Inventor
Thomas R Bailey
Dorothy C Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viropharma Biologics LLC
Original Assignee
Viropharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viropharma Inc filed Critical Viropharma Inc
Publication of EP1128832A1 publication Critical patent/EP1128832A1/en
Publication of EP1128832A4 publication Critical patent/EP1128832A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EP99942288A 1998-08-21 1999-08-19 Compounds, compositions and methods for treating or preventing viral infections and associated diseases Withdrawn EP1128832A4 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US9747698P 1998-08-21 1998-08-21
US97476P 1998-08-21
US11321298P 1998-12-22 1998-12-22
US113212P 1998-12-22
US11932899P 1999-02-09 1999-02-09
US119328P 1999-02-09
US13558699P 1999-05-24 1999-05-24
US13558599P 1999-05-24 1999-05-24
US135586P 1999-05-24
US135585P 1999-05-24
PCT/US1999/018785 WO2000010573A1 (en) 1998-08-21 1999-08-19 Compounds, compositions and methods for treating or preventing viral infections and associated diseases

Publications (2)

Publication Number Publication Date
EP1128832A1 EP1128832A1 (en) 2001-09-05
EP1128832A4 true EP1128832A4 (en) 2003-03-05

Family

ID=27536838

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99942288A Withdrawn EP1128832A4 (en) 1998-08-21 1999-08-19 Compounds, compositions and methods for treating or preventing viral infections and associated diseases

Country Status (10)

Country Link
EP (1) EP1128832A4 (en)
JP (1) JP2002523371A (en)
KR (1) KR20010099623A (en)
CN (1) CN1325309A (en)
AU (1) AU743411B2 (en)
BR (1) BR9913157A (en)
CA (1) CA2341970A1 (en)
ID (1) ID27787A (en)
IL (1) IL141456A0 (en)
WO (1) WO2000010573A1 (en)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200103562T2 (en) * 1999-06-10 2002-04-22 Warner-Lambert Company Rhodanine derivatives for use in the method of preventing amyloid protein aggregation and imaging amyloid deposits
MXPA02002257A (en) 1999-08-31 2002-09-30 Maxia Pharmaceuticals Inc Benzylidene thiazolidinediones and analogues and their use in the treatment of diabetes.
AU2001253206A1 (en) 2000-04-05 2001-10-23 Tularik, Inc. Ns5b hcv polymerase inhibitors
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
YU23503A (en) * 2000-09-29 2006-03-03 Neurogen Corporation High afinity small molecule c5a receptor modulators
CA2440184A1 (en) 2001-03-07 2002-09-19 Incyte San Diego, Inc. Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
EP1377559A4 (en) 2001-03-08 2005-09-28 Incyte San Diego Inc Rxr activating molecules
GB2376944A (en) * 2001-05-18 2002-12-31 Pantherix Ltd Polycyclic heterocyclic compounds and their therapeutic use
US6841566B2 (en) 2001-07-20 2005-01-11 Boehringer Ingelheim, Ltd. Viral polymerase inhibitors
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
EP1429759A4 (en) 2001-09-26 2004-12-15 Bristol Myers Squibb Co Compounds useful for treating hepatitus c virus
JP2005513026A (en) 2001-11-15 2005-05-12 インサイト サン ディエゴ インコーポレイテッド Hypercholesterolemia, dyslipidemia and other metabolic disorders; N-substituted heterocycles to treat cancer and other diseases
US7196108B2 (en) 2002-03-08 2007-03-27 Incyte San Diego Inc. Bicyclic heterocycles for the treatment of diabetes and other diseases
US7102000B2 (en) 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
GB2387172A (en) * 2002-03-28 2003-10-08 Pantherix Ltd [(Aryl-/arylthio-)aryl]methylene substituted azole & azine derivatives and their therapeutic use as antibacterials
US20060281798A1 (en) * 2002-05-17 2006-12-14 Qlt Inc. Methods of using thiazolidinedithione derivatives
ATE503764T1 (en) 2002-05-20 2011-04-15 Bristol Myers Squibb Co HEPATITIS C VIRUS INHIBITORS
AU2003301959A1 (en) 2002-05-20 2004-06-03 Bristol-Myers Squibb Company Substituted cycloalkyl p1' hepatitis c virus inhibitors
ATE481106T1 (en) 2002-05-20 2010-10-15 Bristol Myers Squibb Co HETEROCYCLIC SULFONAMIDE HEPATITIS C VIRUS INHIBITORS
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
US7041690B2 (en) 2002-07-01 2006-05-09 Pharmacia & Upjohn Company, Llc Inhibitors of HCV NS5B polymerase
BR0305259A (en) 2002-07-01 2004-10-05 Upjohn Co Hcv ns5b polymerase inhibitors
FR2845000B1 (en) * 2002-09-27 2005-05-27 Oreal USE OF A HETEROCYCLIC COMPOUND OR ONE OF ITS SALTS FOR STIMULATING OR INDUCING THE GROWTH OF HAIR AND / OR BRAKING THEIR FALL
AU2003277162C1 (en) * 2002-09-30 2009-12-24 The Regents Of The University Of California Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof
US7235573B2 (en) 2002-09-30 2007-06-26 The Regents Of The University Of California Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
US20060276520A1 (en) * 2002-11-13 2006-12-07 Rigel Pharmaceuticals, Inc. Rhodanine derivatives and pharmaceutical compositions containing them
WO2004094452A2 (en) 2003-04-16 2004-11-04 Bristol-Myers Squibb Company Macrocyclic isoquinoline peptide inhibitors of hepatitis c virus
EP1651226B1 (en) 2003-07-11 2010-02-24 Proteologics, Inc. Ubiquitin ligase inhibitors and methods related thereto
FR2858324A1 (en) * 2003-07-30 2005-02-04 Centre Nat Rech Scient Composition used for treating microbial infections, effective particularly against rifampicin-resistant bacteria, contain new or known 5-(heterocyclylmethylene)-thiazolidine derivatives
US7112601B2 (en) 2003-09-11 2006-09-26 Bristol-Myers Squibb Company Cycloalkyl heterocycles for treating hepatitis C virus
US7566732B2 (en) 2003-10-28 2009-07-28 Rigel Pharmaceuticals, Inc. Rhodanine compositions for use as antiviral agents
US7026339B2 (en) 2003-11-07 2006-04-11 Fan Yang Inhibitors of HCV NS5B polymerase
US7132504B2 (en) 2003-11-12 2006-11-07 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7309708B2 (en) 2003-11-20 2007-12-18 Birstol-Myers Squibb Company Hepatitis C virus inhibitors
US7135462B2 (en) 2003-11-20 2006-11-14 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP1718608B1 (en) 2004-02-20 2013-07-17 Boehringer Ingelheim International GmbH Viral polymerase inhibitors
DE602005013922D1 (en) 2004-02-24 2009-05-28 Japan Tobacco Inc CONDENSED HETEROTETRACYCLIC COMPOUNDS AND THEIR USE AS HCV POLYMERASE INHIBITOR
US20070049593A1 (en) 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
US7659263B2 (en) 2004-11-12 2010-02-09 Japan Tobacco Inc. Thienopyrrole compound and use thereof as HCV polymerase inhibitor
EP1879885A1 (en) 2005-05-04 2008-01-23 F. Hoffmann-Roche AG Heterocyclic antiviral compounds
WO2006138118A2 (en) * 2005-06-15 2006-12-28 New York Blood Center Anti-viral compositions comprising heterocyclic substituted phenyl furans and related compounds
US8017612B2 (en) 2006-04-18 2011-09-13 Japan Tobacco Inc. Piperazine compound and use thereof as a HCV polymerase inhibitor
EP2019830A4 (en) * 2006-05-04 2011-01-19 Inst Hepatitis & Virus Res Inhibitors of secretion of hepatitis b virus antigens for treatment of a chronic hepatitis virus
CN101573370B (en) 2006-10-10 2013-09-11 美迪维尔公司 HCV nucleoside inhibitor
WO2008082537A2 (en) 2006-12-19 2008-07-10 The General Hospital Corporation Compounds for modulating integrin cd11b/cd18
AP2874A (en) 2007-06-29 2014-03-31 Gilead Sciences Inc Antiviral compounds
CA2692145C (en) 2007-06-29 2015-03-03 Gilead Sciences, Inc. Antiviral compounds
JP2011502998A (en) 2007-11-01 2011-01-27 ザ ユーエイビー リサーチ ファウンデイション Treatment and prevention of viral infection
US20110015158A1 (en) 2007-12-11 2011-01-20 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
US7947717B2 (en) 2008-07-18 2011-05-24 Burnham Institute For Medical Research Inhibitors of lethal factor protease
BRPI0922366B8 (en) 2008-12-03 2021-05-25 Presidio Pharmaceuticals Inc compound, pharmaceutical composition and use of a compound
US8865756B2 (en) 2008-12-03 2014-10-21 Presidio Pharmaceuticals, Inc. Inhibitors of HCV NS5A
US9150554B2 (en) 2009-03-27 2015-10-06 Presidio Pharmaceuticals, Inc. Fused ring inhibitors of hepatitis C
MX2012005528A (en) 2009-11-14 2012-06-12 Hoffmann La Roche Biomarkers for predicting rapid response to hcv treatment.
SG181104A1 (en) 2009-12-02 2012-07-30 Hoffmann La Roche Biomarkers for predicting sustained response to hcv treatment
EP2515903A4 (en) * 2009-12-23 2013-07-10 Peter Maccallum Cancer Inst Compounds, preparations and uses thereof
EP2575866A4 (en) 2010-05-24 2013-10-16 Presidio Pharmaceuticals Inc Inhibitors of hcv ns5a
KR101159000B1 (en) * 2010-06-18 2012-06-21 (주) 에빅스젠 Novel rhodanine derivative, process for preparing the same and pharmaceutical composition for preventing or treating AIDS comprising the same
US9023876B2 (en) 2010-07-08 2015-05-05 Adhaere Pharmaceuticals, Inc. Compounds and methods for regulating integrins
US9255088B2 (en) 2010-08-11 2016-02-09 The Regents Of The University Of California Premature-termination-codons readthrough compounds
WO2012123298A1 (en) 2011-03-11 2012-09-20 F. Hoffmann-La Roche Ag Antiviral compounds
WO2012175581A1 (en) 2011-06-24 2012-12-27 F. Hoffmann-La Roche Ag Antiviral compounds
CN103917541B (en) 2011-10-10 2016-08-17 弗·哈夫曼-拉罗切有限公司 Antiviral compound
US9133170B2 (en) 2011-12-16 2015-09-15 Hoffmann-La Roche Inc. Inhibitors of HCV NS5A
CA2856179C (en) 2011-12-20 2017-02-28 F. Hoffmann-La Roche Ag 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication
SI2794628T1 (en) 2011-12-20 2017-07-31 Riboscience Llc 4'-azido-3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication
BR112014015582A8 (en) 2012-02-24 2017-07-04 Hoffmann La Roche antiviral compounds
WO2013142346A1 (en) 2012-03-23 2013-09-26 The Regents Of The University Of California Premature-termination-codons readthrough compounds
ES2766751T3 (en) 2012-04-20 2020-06-15 Gb006 Inc Compositions for the regulation of integrins
US20140010783A1 (en) 2012-07-06 2014-01-09 Hoffmann-La Roche Inc. Antiviral compounds
RU2015132550A (en) 2013-01-23 2017-03-02 Ф. Хоффманн-Ля Рош Аг TRIAZOLE ANTIVIRAL DERIVATIVES
CA2900319A1 (en) 2013-03-05 2014-09-12 F. Hoffmann-La Roche Ag Antiviral compounds
RU2534613C2 (en) 2013-03-22 2014-11-27 Александр Васильевич Иващенко Alkyl2-{[(2r,3s,5r)-5-(4-amino-2-oxo-2h-pyrimidine-1-yl)- -hydroxy- tetrahydro-furan-2-ylmethoxy]-phenoxy-phosphorylamino}-proptonates, nucleoside inhibitors of rna-polymerase hcv ns5b, methods for producing and using them
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
EA035301B1 (en) 2013-05-16 2020-05-26 Рибосайенс Ллк 4'-fluoro-2'-methyl substituted nucleoside derivatives
US9249176B2 (en) 2013-05-16 2016-02-02 Riboscience Llc 4′-azido, 3′-deoxy-3′-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication
EP3684374A4 (en) 2017-09-21 2021-06-16 Riboscience LLC 4'-fluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication
KR101893988B1 (en) 2018-05-16 2018-08-31 (주)에빅스젠 Pharmaceutical composition comprising Rhodanine derivative for preventing or treating AIDS
WO2023161427A1 (en) 2022-02-24 2023-08-31 Eisbach Bio Gmbh Viral combination therapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021934A1 (en) * 1992-05-01 1993-11-11 Commonwealth Scientific And Industrial Research Organisation Heteropolytungstates in the treatment of flavivirus infections
WO1998020013A1 (en) * 1996-11-07 1998-05-14 Andreas Johannes Kesel New knoevenagel condensation products, method for their production and their use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909467A (en) * 1958-07-09 1959-10-20 Us Vitamin Pharm Corp 3-(d-alpha-methylphenethyl)-5-methyl-1, 3-oxazolidine-2, 4-dione
US3888984A (en) * 1972-03-13 1975-06-10 Lilly Industries Ltd Oxazole and imidazole derivatives as antifungal agents
AU6610081A (en) * 1980-01-24 1981-07-30 Senju Pharmaceutical Co., Ltd. Thiazolidine derivatives
US4367234A (en) * 1980-07-28 1983-01-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US5693337A (en) * 1994-07-13 1997-12-02 Wakamoto Pharmaceutical Co., Ltd. Stable lipid emulsion
US5834466A (en) * 1994-12-22 1998-11-10 The Regents Of The University Of California Method for protecting of heart by limiting metabolic and ionic abnormalities developed during ischemia, following ischemia or resulting from ischemia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021934A1 (en) * 1992-05-01 1993-11-11 Commonwealth Scientific And Industrial Research Organisation Heteropolytungstates in the treatment of flavivirus infections
WO1998020013A1 (en) * 1996-11-07 1998-05-14 Andreas Johannes Kesel New knoevenagel condensation products, method for their production and their use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0010573A1 *

Also Published As

Publication number Publication date
IL141456A0 (en) 2002-03-10
AU5570299A (en) 2000-03-14
EP1128832A1 (en) 2001-09-05
CN1325309A (en) 2001-12-05
JP2002523371A (en) 2002-07-30
KR20010099623A (en) 2001-11-09
ID27787A (en) 2001-04-26
AU743411B2 (en) 2002-01-24
BR9913157A (en) 2001-05-15
WO2000010573A1 (en) 2000-03-02
CA2341970A1 (en) 2000-03-02

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