EP1128832A4 - Composes, compositions et procedes pour traiter des infections virales et les maladies qui y sont liees - Google Patents

Composes, compositions et procedes pour traiter des infections virales et les maladies qui y sont liees

Info

Publication number
EP1128832A4
EP1128832A4 EP99942288A EP99942288A EP1128832A4 EP 1128832 A4 EP1128832 A4 EP 1128832A4 EP 99942288 A EP99942288 A EP 99942288A EP 99942288 A EP99942288 A EP 99942288A EP 1128832 A4 EP1128832 A4 EP 1128832A4
Authority
EP
European Patent Office
Prior art keywords
compositions
treating
compounds
methods
viral infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99942288A
Other languages
German (de)
English (en)
Other versions
EP1128832A1 (fr
Inventor
Thomas R Bailey
Dorothy C Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viropharma Biologics LLC
Original Assignee
Viropharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viropharma Inc filed Critical Viropharma Inc
Publication of EP1128832A1 publication Critical patent/EP1128832A1/fr
Publication of EP1128832A4 publication Critical patent/EP1128832A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
EP99942288A 1998-08-21 1999-08-19 Composes, compositions et procedes pour traiter des infections virales et les maladies qui y sont liees Withdrawn EP1128832A4 (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US9747698P 1998-08-21 1998-08-21
US97476P 1998-08-21
US11321298P 1998-12-22 1998-12-22
US113212P 1998-12-22
US11932899P 1999-02-09 1999-02-09
US119328P 1999-02-09
US13558699P 1999-05-24 1999-05-24
US13558599P 1999-05-24 1999-05-24
US135586P 1999-05-24
US135585P 1999-05-24
PCT/US1999/018785 WO2000010573A1 (fr) 1998-08-21 1999-08-19 Composes, compositions et procedes pour traiter des infections virales et les maladies qui y sont liees

Publications (2)

Publication Number Publication Date
EP1128832A1 EP1128832A1 (fr) 2001-09-05
EP1128832A4 true EP1128832A4 (fr) 2003-03-05

Family

ID=27536838

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99942288A Withdrawn EP1128832A4 (fr) 1998-08-21 1999-08-19 Composes, compositions et procedes pour traiter des infections virales et les maladies qui y sont liees

Country Status (10)

Country Link
EP (1) EP1128832A4 (fr)
JP (1) JP2002523371A (fr)
KR (1) KR20010099623A (fr)
CN (1) CN1325309A (fr)
AU (1) AU743411B2 (fr)
BR (1) BR9913157A (fr)
CA (1) CA2341970A1 (fr)
ID (1) ID27787A (fr)
IL (1) IL141456A0 (fr)
WO (1) WO2000010573A1 (fr)

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EA200200311A1 (ru) 1999-08-31 2002-08-29 Максиа Фармасьютикалз, Инк. Бензилиден-тиазолидиндионы и аналоги и их применение для лечения диабета
US6727267B2 (en) 2000-04-05 2004-04-27 Tularik Inc. NS5B HVC polymerase inhibitors
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
IL154993A0 (en) * 2000-09-29 2003-10-31 Neurogen Corp High affinity small molecule c5a receptor modulators
PL373912A1 (en) 2001-03-07 2005-09-19 Incyte San Diego, Inc. Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
US7265139B2 (en) 2001-03-08 2007-09-04 Incyte San Diego Inc. RXR activating molecules
GB2376944A (en) * 2001-05-18 2002-12-31 Pantherix Ltd Polycyclic heterocyclic compounds and their therapeutic use
WO2003007945A1 (fr) 2001-07-20 2003-01-30 Boehringer Ingelheim (Canada) Ltd. Inhibiteurs de polymerase virale
EP2335700A1 (fr) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Inhibiteurs de la polymerase du virus hepatitis C avec une structure heterobicylic
US20030134853A1 (en) 2001-09-26 2003-07-17 Priestley Eldon Scott Compounds useful for treating hepatitis C virus
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US7102000B2 (en) 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
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GB2387172A (en) * 2002-03-28 2003-10-08 Pantherix Ltd [(Aryl-/arylthio-)aryl]methylene substituted azole & azine derivatives and their therapeutic use as antibacterials
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FR2845000B1 (fr) 2002-09-27 2005-05-27 Oreal Utilisation d'un compose heterocyclique ou de l'un de ses sels pour stimuler ou induire la pousse des cheveux et/ou freiner leur chute
US7235573B2 (en) 2002-09-30 2007-06-26 The Regents Of The University Of California Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
KR20050061501A (ko) * 2002-09-30 2005-06-22 더 리전트 오브 더 유니버시티 오브 캘리포니아 낭종 섬유증 트랜스막 전도도 조절기 단백질 억제제 및이의 용도
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CN108409820A (zh) 2011-12-20 2018-08-17 里博科学有限责任公司 作为hcv rna复制抑制剂的4′-叠氮基，3′-氟取代的核苷衍生物
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JP6092261B2 (ja) 2012-02-24 2017-03-08 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗ウイルス化合物
EP2828249B1 (fr) 2012-03-23 2018-10-10 The Regents of The University of California Composés de translecture de codons de terminaison prématurés
ES2766751T3 (es) 2012-04-20 2020-06-15 Gb006 Inc Composiciones para la regulación de integrinas
US20140010783A1 (en) 2012-07-06 2014-01-09 Hoffmann-La Roche Inc. Antiviral compounds
MX2015009176A (es) 2013-01-23 2015-11-09 Hoffmann La Roche Derivados de triazola antivirales.
MX2015011193A (es) 2013-03-05 2015-11-13 Hoffmann La Roche Compuestos antivirales.
RU2534613C2 (ru) 2013-03-22 2014-11-27 Александр Васильевич Иващенко Алкил 2-{ [(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)- -гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино} -пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения
CN105307662B (zh) 2013-05-16 2019-06-04 里博科学有限责任公司 4’-氟-2’-甲基取代的核苷衍生物
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
AU2014272055A1 (en) 2013-05-16 2015-12-24 Riboscience Llc 4'-azido, 3'-deoxy-3'-fluoro substituted nucleoside derivatives
EP3684374A4 (fr) 2017-09-21 2021-06-16 Riboscience LLC Dérivés nucléosidiques à substitution 4'-fluoro-2'-méthyle utilisés comme inhibiteurs de la réplication de l'arn du vhc
KR101893988B1 (ko) 2018-05-16 2018-08-31 (주)에빅스젠 로다닌 유도체를 함유하는 aids 예방 또는 치료용 약학 조성물
WO2023161427A1 (fr) 2022-02-24 2023-08-31 Eisbach Bio Gmbh Polythérapie virale

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WO1998020013A1 (fr) * 1996-11-07 1998-05-14 Andreas Johannes Kesel Nouveaux produits de condensation de knoevenagel, leur procede de production et leur utilisation

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WO1993021934A1 (fr) * 1992-05-01 1993-11-11 Commonwealth Scientific And Industrial Research Organisation Heteropolytungstates utilises dans le traitement des infections a flavivirus
WO1998020013A1 (fr) * 1996-11-07 1998-05-14 Andreas Johannes Kesel Nouveaux produits de condensation de knoevenagel, leur procede de production et leur utilisation

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Also Published As

Publication number Publication date
ID27787A (id) 2001-04-26
JP2002523371A (ja) 2002-07-30
CN1325309A (zh) 2001-12-05
IL141456A0 (en) 2002-03-10
KR20010099623A (ko) 2001-11-09
BR9913157A (pt) 2001-05-15
EP1128832A1 (fr) 2001-09-05
AU743411B2 (en) 2002-01-24
CA2341970A1 (fr) 2000-03-02
AU5570299A (en) 2000-03-14
WO2000010573A1 (fr) 2000-03-02

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