EA200200311A1 - Бензилиден-тиазолидиндионы и аналоги и их применение для лечения диабета - Google Patents

Бензилиден-тиазолидиндионы и аналоги и их применение для лечения диабета

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Publication number
EA200200311A1
EA200200311A1 EA200200311A EA200200311A EA200200311A1 EA 200200311 A1 EA200200311 A1 EA 200200311A1 EA 200200311 A EA200200311 A EA 200200311A EA 200200311 A EA200200311 A EA 200200311A EA 200200311 A1 EA200200311 A1 EA 200200311A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diabetes
disease
tiazolidindiones
benzylidene
analogues
Prior art date
Application number
EA200200311A
Other languages
English (en)
Inventor
Магнус Пфаль
Кэтрин Тачджиан
Хуссейн А. Аль-Шамма
Андреа Фанджул
Дэвид П. Н. Плейнет
Лайл В. Спрюс
Original Assignee
Максиа Фармасьютикалз, Инк.
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Filing date
Publication date
Application filed by Максиа Фармасьютикалз, Инк. filed Critical Максиа Фармасьютикалз, Инк.
Publication of EA200200311A1 publication Critical patent/EA200200311A1/ru

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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P3/06—Antihyperlipidemics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
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    • C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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    • C07—ORGANIC CHEMISTRY
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    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
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    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Настоящее изобретение относится к определенным замещенным гетероциклам формулы (I)которые применяют для лечения заболеваний, связанных с липидным и углеводным метаболизмом, как, например, диабет типа 2, дифференцировка адипоцитов, неконтролируемая пролиферация, такая как лимфома, болезнь Ходжкина, лейкоз, рак молочной железы, рак простаты или общие формы рака, и воспаление, как, например, остеоартрит, ревматоидный артрит, болезнь Крона или воспалительное заболевание кишечника.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200311A 1999-08-31 2000-08-31 Бензилиден-тиазолидиндионы и аналоги и их применение для лечения диабета EA200200311A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15167099P 1999-08-31 1999-08-31
PCT/US2000/024222 WO2001016122A1 (en) 1999-08-31 2000-08-31 Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes

Publications (1)

Publication Number Publication Date
EA200200311A1 true EA200200311A1 (ru) 2002-08-29

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EA200200311A EA200200311A1 (ru) 1999-08-31 2000-08-31 Бензилиден-тиазолидиндионы и аналоги и их применение для лечения диабета

Country Status (23)

Country Link
US (4) US6515003B1 (ru)
EP (2) EP1214304B1 (ru)
JP (2) JP2003531104A (ru)
CN (1) CN1384825A (ru)
AT (1) ATE302764T1 (ru)
AU (2) AU7349100A (ru)
BR (1) BR0013671A (ru)
CA (2) CA2383347A1 (ru)
DE (1) DE60022207T2 (ru)
DK (1) DK1214304T3 (ru)
EA (1) EA200200311A1 (ru)
ES (1) ES2248107T3 (ru)
HK (1) HK1047591A1 (ru)
HU (1) HUP0203367A3 (ru)
IL (1) IL148361A0 (ru)
MX (1) MXPA02002257A (ru)
NO (1) NO322701B1 (ru)
NZ (1) NZ517993A (ru)
PL (1) PL354334A1 (ru)
TW (1) TWI279401B (ru)
UA (1) UA74344C2 (ru)
WO (2) WO2001016123A1 (ru)
ZA (2) ZA200202064B (ru)

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