AU2001294673A1 - Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, andatherosclerosis - Google Patents
Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, andatherosclerosisInfo
- Publication number
- AU2001294673A1 AU2001294673A1 AU2001294673A AU9467301A AU2001294673A1 AU 2001294673 A1 AU2001294673 A1 AU 2001294673A1 AU 2001294673 A AU2001294673 A AU 2001294673A AU 9467301 A AU9467301 A AU 9467301A AU 2001294673 A1 AU2001294673 A1 AU 2001294673A1
- Authority
- AU
- Australia
- Prior art keywords
- andatherosclerosis
- hyperlipidemia
- diabetes
- treatment
- compounds useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23442300P | 2000-09-21 | 2000-09-21 | |
| US60234423 | 2000-09-21 | ||
| US31479201P | 2001-08-24 | 2001-08-24 | |
| US60314792 | 2001-08-24 | ||
| PCT/US2001/029853 WO2002024689A1 (en) | 2000-09-21 | 2001-09-21 | Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001294673A1 true AU2001294673A1 (en) | 2002-04-02 |
Family
ID=26927913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001294673A Abandoned AU2001294673A1 (en) | 2000-09-21 | 2001-09-21 | Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, andatherosclerosis |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US6784199B2 (en) |
| AU (1) | AU2001294673A1 (en) |
| WO (1) | WO2002024689A1 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030054974A1 (en) * | 2001-08-24 | 2003-03-20 | Aryx Therapeutics | Non-oxidatively metabolized compounds and compositions, synthetic pathways therefor, and uses thereof |
| US6958355B2 (en) | 2000-04-24 | 2005-10-25 | Aryx Therapeutics, Inc. | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| US6768008B2 (en) * | 2000-04-24 | 2004-07-27 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| US6680387B2 (en) | 2000-04-24 | 2004-01-20 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| US7049326B2 (en) * | 2000-05-12 | 2006-05-23 | The University Of Toledo | Method and compositions for temporarily incapacitating subjects |
| US6756047B2 (en) * | 2000-05-12 | 2004-06-29 | The University Of Toledo | Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs |
| US6750238B1 (en) | 2000-05-12 | 2004-06-15 | The University Of Toledo | Aralkyl ester soft drugs |
| AU2001294673A1 (en) | 2000-09-21 | 2002-04-02 | Aryx Therapeutics | Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, andatherosclerosis |
| US20030073712A1 (en) * | 2001-07-23 | 2003-04-17 | Bing Wang | Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods |
| JP2005533851A (en) | 2002-07-19 | 2005-11-10 | アリックス セラピューティクス、インコーポレイテッド | Substances and methods for treating hypercholesterolemia |
| CN107827827A (en) * | 2017-12-13 | 2018-03-23 | 南京中医药大学 | A kind of synthesis technique of H168 |
| HRP20220331T1 (en) | 2018-03-08 | 2022-05-13 | Incyte Corporation | Aminopyrazine diol compounds as pi3k-y inhibitors |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5522636A (en) | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| US4281200A (en) * | 1979-08-30 | 1981-07-28 | The Dow Chemical Company | Catalytic process for converting oxazolidinones to their corresponding aminoalcohols |
| JPS5697277A (en) | 1980-01-07 | 1981-08-05 | Takeda Chem Ind Ltd | Thiazolidine derivative |
| JPS58118577A (en) | 1982-01-07 | 1983-07-14 | Takeda Chem Ind Ltd | Thiazolidine derivative |
| JPS6051189A (en) | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | Thiazolidine derivative and its preparation |
| CN1003445B (en) | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | The preparation method of thiazolidine diketone derivative |
| AR240698A1 (en) | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Process for the preparation of 5-(4-(2-(5-ethyl-2-pyridil)-ethoxy)benzyl)-2,4-thiazolodinedione and their salts |
| HU210339B (en) | 1985-05-21 | 1995-03-28 | Pfizer | Process for preparing thiazolidinediones and their pharmaceutical compositions haring hypoglycemic effect |
| US4873255A (en) | 1987-02-04 | 1989-10-10 | Sankyo Company Limited | Thiazolidinone derivatives, their preparation and their use |
| FI91869C (en) | 1987-03-18 | 1994-08-25 | Tanabe Seiyaku Co | Process for the preparation of benzoxazole derivatives as antidiabetic agents |
| EP0295828A1 (en) | 1987-06-13 | 1988-12-21 | Beecham Group Plc | Novel compounds |
| US5260445A (en) | 1987-09-04 | 1993-11-09 | Beecham Group P.L.C. | 2,4-thiazolidinediones |
| US5232925A (en) | 1987-09-04 | 1993-08-03 | Beecham Group P.L.C. | Compounds |
| US5194443A (en) | 1987-09-04 | 1993-03-16 | Beecham Group P.L.C. | Compounds |
| EP0306228B1 (en) | 1987-09-04 | 1999-11-17 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| US5061717A (en) | 1988-03-08 | 1991-10-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| US5120754A (en) | 1988-03-08 | 1992-06-09 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| US5223522A (en) | 1988-03-08 | 1993-06-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| MX15171A (en) | 1988-03-08 | 1993-05-01 | Pfizer | DERIVATIVES OF TIAZOLIDINODIONA HIPOGLICEMICOS |
| US4897405A (en) | 1989-04-21 | 1990-01-30 | American Home Products Corporation | Novel naphthalenylalkyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents |
| GB8919434D0 (en) | 1989-08-25 | 1989-10-11 | Beecham Group Plc | Novel compounds |
| GB8919417D0 (en) | 1989-08-25 | 1989-10-11 | Beecham Group Plc | Novel compounds |
| WO1991007107A1 (en) | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
| US5677330A (en) | 1990-02-12 | 1997-10-14 | The Center For Innovative Technology | Medical uses of allosteric hemoglobin modifier compounds in patient care |
| GB9017218D0 (en) | 1990-08-06 | 1990-09-19 | Beecham Group Plc | Novel compounds |
| FR2680512B1 (en) * | 1991-08-20 | 1995-01-20 | Adir | NOVEL 2,4-THIAZOLIDINEDIONE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| EP0635007A1 (en) | 1992-04-10 | 1995-01-25 | Smithkline Beecham Plc | Heterocyclic compounds and their use in the treatment of type ii-diabetes |
| WO1994001433A1 (en) | 1992-07-13 | 1994-01-20 | Japan Tobacco Inc. | Novel thiazolidinedione compound and use thereof |
| DE69418311T2 (en) | 1993-12-27 | 1999-11-04 | Japan Tobacco Inc | ISOXAZOLIDE INDION DERIVATIVES AND THEIR USE |
| US5480896A (en) | 1994-01-27 | 1996-01-02 | American Home Products Corporation | Aralkyl-1,2,4-oxadiazolidine-3,5-diones as antihyperglycemic agents |
| CA2227829A1 (en) | 1995-07-31 | 1997-02-13 | Shionogi & Co., Ltd. | Pyrrolidine derivatives having phospholipase a2 inhibitory activity |
| DE69625795T2 (en) | 1996-04-09 | 2003-08-14 | Reddys Lab Ltd Dr | Thiazolidinedione derivatives with antidiabetic, hypolipidemic and antihypertensive properties, processes for their preparation and pharmaceutical compositions containing them |
| HUP9903292A3 (en) | 1996-05-31 | 2000-08-28 | Sankyo Co | Use of substances improving insulin resistance for production of remedies for autoimmune diseases |
| AU740444B2 (en) | 1996-08-19 | 2001-11-01 | Japan Tobacco Inc. | Propionic acid derivatives and use thereof |
| US6121288A (en) | 1996-11-08 | 2000-09-19 | Nippon Chemiphar Co., Ltd. | Visceral fat lowering agent |
| AU1052599A (en) | 1997-11-12 | 1999-05-31 | Institute Of Medicinal Molecular Design. Inc. | Retinoid receptor agonists |
| HUP9902721A2 (en) * | 1997-11-25 | 1999-12-28 | The Procter & Gamble Co. | Concentrated fabric softening composition and highly unsaturated fabric softener compound therefor |
| EP1036075B1 (en) | 1997-12-02 | 2004-06-23 | Dr. Reddy's Laboratories Ltd. | Substituted thiazolidinedione and oxazolidinedione having antidiabetic, hypolipidemia and antihypertensive properties |
| KR100321608B1 (en) | 1998-03-30 | 2002-02-02 | 미즈노 마사루 | Process for producing isooxazolidinedione compound |
| ES2154551B1 (en) | 1998-08-03 | 2001-10-16 | Vita Invest Sa | NEW DERIVATIVES OF TETRAZOL AS ANTIDIABETIC AGENTS. |
| GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
| CA2385798A1 (en) | 1999-06-25 | 2001-01-04 | Michael C. Van Zandt | Substituted phenoxyacetic acids |
| WO2001002377A1 (en) | 1999-07-01 | 2001-01-11 | Geron Corporation | Telomerase inhibitors and methods of their use |
| AUPQ253199A0 (en) | 1999-08-30 | 1999-09-23 | Fujisawa Pharmaceutical Co., Ltd. | Non-prostanoid prostaglandin I2-agonist |
| NZ517993A (en) | 1999-08-31 | 2004-03-26 | Incyte San Diego Inc | Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes |
| US6680387B2 (en) | 2000-04-24 | 2004-01-20 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| EP1276730A2 (en) | 2000-04-24 | 2003-01-22 | ARYx Therapeutics | Thiazolidinedione analogues and their use for the treatment of diabetes |
| US6768008B2 (en) | 2000-04-24 | 2004-07-27 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| AU2001294673A1 (en) | 2000-09-21 | 2002-04-02 | Aryx Therapeutics | Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, andatherosclerosis |
| JPWO2002044127A1 (en) | 2000-11-29 | 2004-04-02 | 杏林製薬株式会社 | Substituted carboxylic acid derivatives |
-
2001
- 2001-09-21 AU AU2001294673A patent/AU2001294673A1/en not_active Abandoned
- 2001-09-21 US US09/961,538 patent/US6784199B2/en not_active Expired - Fee Related
- 2001-09-21 WO PCT/US2001/029853 patent/WO2002024689A1/en active Application Filing
-
2004
- 2004-06-15 US US10/869,516 patent/US20040254180A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040254180A1 (en) | 2004-12-16 |
| US20020045620A1 (en) | 2002-04-18 |
| US6784199B2 (en) | 2004-08-31 |
| WO2002024689A1 (en) | 2002-03-28 |
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