TR200103562T2 - Rhodanine derivatives for use in the method of preventing amyloid protein aggregation and imaging amyloid deposits - Google Patents

Rhodanine derivatives for use in the method of preventing amyloid protein aggregation and imaging amyloid deposits

Info

Publication number
TR200103562T2
TR200103562T2 TR2001/03562T TR200103562T TR200103562T2 TR 200103562 T2 TR200103562 T2 TR 200103562T2 TR 2001/03562 T TR2001/03562 T TR 2001/03562T TR 200103562 T TR200103562 T TR 200103562T TR 200103562 T2 TR200103562 T2 TR 200103562T2
Authority
TR
Turkey
Prior art keywords
protein aggregation
amyloid
preventing
imaging
rhodanine derivatives
Prior art date
Application number
TR2001/03562T
Other languages
Turkish (tr)
Inventor
Elizabeth Augelli-Szafran Corinne
Ann Glase Shelly
Craswell Walker Lary
Yasunaga Tomoyuki
Original Assignee
Warner-Lambert Company
Yamanouchi Pharmaceutical Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company, Yamanouchi Pharmaceutical Company filed Critical Warner-Lambert Company
Publication of TR200103562T2 publication Critical patent/TR200103562T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Mevcut bulus Alzheimer hastaligini tedavi etmek için, bir Formül (I) bilesiginin kullanildigi bir yöntem saglamaktadir. Bulus ayrica, amiloid proteinlerinin toplanmasini inhibe etmek için bir formül formül (I) bilesiginin kulalanildigi bir yöntem ve amiloid birikintilerinin görüntülenmesi için formül (I) bilesiklerinin kullanildigi bir yöntem saglamaktadir.The present invention provides a method of using a compound of Formula (I) to treat Alzheimer's disease. The invention also provides a method of using a compound of formula (I) to inhibit the aggregation of amyloid proteins, and a method using compounds of formula (I) to display amyloid deposits.

TR2001/03562T 1999-06-10 2000-05-31 Rhodanine derivatives for use in the method of preventing amyloid protein aggregation and imaging amyloid deposits TR200103562T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13854499P 1999-06-10 1999-06-10

Publications (1)

Publication Number Publication Date
TR200103562T2 true TR200103562T2 (en) 2002-04-22

Family

ID=22482512

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03562T TR200103562T2 (en) 1999-06-10 2000-05-31 Rhodanine derivatives for use in the method of preventing amyloid protein aggregation and imaging amyloid deposits

Country Status (8)

Country Link
EP (1) EP1192143A1 (en)
JP (1) JP2003502320A (en)
AU (1) AU5311800A (en)
BR (1) BR0011441A (en)
CA (1) CA2374616A1 (en)
MX (1) MXPA01010490A (en)
TR (1) TR200103562T2 (en)
WO (1) WO2000076987A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020394A1 (en) 2000-08-18 2002-06-21 Agouron Pharma PIRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, MODULATE AND / OR INHIBIT THE ACTIVITY OF ERAB / HADH2
CA2508601A1 (en) 2002-12-06 2004-06-24 Warner-Lambert Company Llc Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k
US20060106077A1 (en) * 2003-07-18 2006-05-18 Pintex Pharmaceuticals, Inc. Pin1-Modulating compounds and methods of use thereof
AU2008215948A1 (en) 2007-02-12 2008-08-21 Merck & Co., Inc. Piperazine derivatives for treatment of AD and related conditions
WO2011160024A2 (en) 2010-06-17 2011-12-22 Fuzians Biomedicals, Inc. Compounds useful as antiviral agents, compositions, and methods of use
CN106045986B (en) * 2016-05-31 2019-12-06 广东工业大学 novel phenothiazine derivative and preparation method and application thereof
CN106045987B (en) * 2016-06-21 2019-04-23 广东工业大学 One kind having multi-functional near-infrared fluorescent magnetic nanoparticle and its preparation and application

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5740478A (en) * 1980-08-22 1982-03-06 Ono Pharmaceut Co Ltd Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative
JPH01147476A (en) * 1987-12-03 1989-06-09 Mita Ind Co Ltd Photoconductive toner
JPH01147462A (en) * 1987-12-03 1989-06-09 Mita Ind Co Ltd Carrier generating material and its production
US5143929A (en) * 1991-05-09 1992-09-01 Warner-Lambert Company 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents
IL106877A (en) * 1992-09-10 1998-03-10 Lilly Co Eli Rhodanine derivatives for use as medicaments for the treatment of alzheimer's disease
DE4318550A1 (en) * 1993-06-04 1994-12-08 Boehringer Mannheim Gmbh Arylidene-4-oxo-2-thioxo-3-thiazolidinecarboxylic acids, process for their preparation and pharmaceutical compositions containing them
US6251928B1 (en) * 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
AU1529297A (en) * 1996-01-24 1997-08-20 Warner-Lambert Company Method of imaging amyloid deposits
KR20010099623A (en) * 1998-08-21 2001-11-09 비로파마 인코포레이티드 Compounds, compositions and methods for treating or preventing viral infections and associated diseases
EP1117655A1 (en) * 1998-09-30 2001-07-25 Angelika Esswein Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders

Also Published As

Publication number Publication date
EP1192143A1 (en) 2002-04-03
CA2374616A1 (en) 2000-12-21
BR0011441A (en) 2002-07-16
WO2000076987A1 (en) 2000-12-21
AU5311800A (en) 2001-01-02
MXPA01010490A (en) 2005-05-27
JP2003502320A (en) 2003-01-21

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