AR060562A1 - Compuestos heterociclicos como antagonistas del receptor il-8. procesos de obtencion y composiciones farmaceuticas. - Google Patents

Compuestos heterociclicos como antagonistas del receptor il-8. procesos de obtencion y composiciones farmaceuticas.

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Publication number
AR060562A1
AR060562A1 ARP070101714A ARP070101714A AR060562A1 AR 060562 A1 AR060562 A1 AR 060562A1 AR P070101714 A ARP070101714 A AR P070101714A AR P070101714 A ARP070101714 A AR P070101714A AR 060562 A1 AR060562 A1 AR 060562A1
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AR
Argentina
Prior art keywords
alkyl
group
obtaining
processes
pharmaceutical compositions
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ARP070101714A
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English (en)
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Smithkline Beecham Corp
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Publication of AR060562A1 publication Critical patent/AR060562A1/es

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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
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    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/60—Naphthoxazoles; Hydrogenated naphthoxazoles
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

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Abstract

Procesos de obtencion de dichos compuestos, composiciones farmacéuticas que los componen y usos de los mismos. Reivindicacion 1: Un compuesto de acuerdo con la formula (1):en la que X se selecciona entre el grupo que consiste en halogeno, alquilo C1-3, alcoxi C1-3, ciano, CF3 y OCF3; R2 se selecciona entre el grupo que consiste en cicloalquilo C3-6, fenilo y heteroarilo, donde los restos fenilo o heteroarilo están opcionalmente sustituidos, una o dos veces, independientemente, con un sustituyente seleccionado entre el grupo que consiste en alquilo C1-3, halogeno, CF3, OCF3, feniloxi y benciloxi; o R2 representa fenilo sustituido con metilenodioxi o con metilenodioxi (dihalo-sustituido); R1 representa heterociclil C4-8(CH2)n, donde el resto heterociclilo está opcionalmente sustituido, independientemente, una o dos veces, con un sustituyente seleccionado entre el grupo que consiste en alquilo C1-3, C(O)OR4 y C(O)R5; R4 y R5 son, independientemente, alquilo C1-3 y n es 0 o 1; o R1 se selecciona entre los siguientes sistemas de anillos (a-k), donde R3 es H o alquilo C1-3; o una sal farmacéuticamente aceptable del mismo.
ARP070101714A 2006-04-21 2007-04-20 Compuestos heterociclicos como antagonistas del receptor il-8. procesos de obtencion y composiciones farmaceuticas. AR060562A1 (es)

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US20110059937A1 (en) 2011-03-10
KR101376472B1 (ko) 2014-03-19
SI2009992T1 (sl) 2012-09-28
EA014958B1 (ru) 2011-04-29
CY1113132T1 (el) 2016-04-13
HK1123683A1 (en) 2009-06-26
ZA200808358B (en) 2009-12-30
US20110105563A1 (en) 2011-05-05
CA2650009C (en) 2014-07-08
TWI414517B (zh) 2013-11-11
JP2009534421A (ja) 2009-09-24
PE20080077A1 (es) 2008-03-29
CR10391A (es) 2008-11-26
IL194811A (en) 2012-09-24
KR20090003345A (ko) 2009-01-09
AU2007240365A1 (en) 2007-11-01
MY145810A (en) 2012-04-30
EA200870465A1 (ru) 2009-04-28
CA2650009A1 (en) 2007-11-01
MX2008013600A (es) 2008-10-31
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US7893089B2 (en) 2011-02-22
US20090093451A1 (en) 2009-04-09

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