EP0939634A4 - Il-8 receptor antagonists - Google Patents

Il-8 receptor antagonists

Info

Publication number
EP0939634A4
EP0939634A4 EP97938426A EP97938426A EP0939634A4 EP 0939634 A4 EP0939634 A4 EP 0939634A4 EP 97938426 A EP97938426 A EP 97938426A EP 97938426 A EP97938426 A EP 97938426A EP 0939634 A4 EP0939634 A4 EP 0939634A4
Authority
EP
European Patent Office
Prior art keywords
receptor antagonists
antagonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97938426A
Other languages
German (de)
French (fr)
Other versions
EP0939634A1 (en
Inventor
Deborah Lynn Bryan
John Gerald Gleason
Katherine L Widdowson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0939634A1 publication Critical patent/EP0939634A1/en
Publication of EP0939634A4 publication Critical patent/EP0939634A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
EP97938426A 1996-08-15 1997-08-15 Il-8 receptor antagonists Withdrawn EP0939634A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2397296P 1996-08-15 1996-08-15
US23972P 1996-08-15
PCT/US1997/014582 WO1998006398A1 (en) 1996-08-15 1997-08-15 Il-8 receptor antagonists

Publications (2)

Publication Number Publication Date
EP0939634A1 EP0939634A1 (en) 1999-09-08
EP0939634A4 true EP0939634A4 (en) 2001-02-21

Family

ID=21818184

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97938426A Withdrawn EP0939634A4 (en) 1996-08-15 1997-08-15 Il-8 receptor antagonists

Country Status (3)

Country Link
EP (1) EP0939634A4 (en)
JP (1) JP2000516620A (en)
WO (1) WO1998006398A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000513360A (en) 1996-06-27 2000-10-10 スミスクライン・ビーチャム・コーポレイション IL-8 receptor antagonist
GB9908410D0 (en) * 1999-04-13 1999-06-09 Pfizer Ltd Pyridines
AR029637A1 (en) * 1999-05-28 2003-07-10 Smithkline Beecham Corp GUANIDINE COMPOUNDS, ANTAGONISTS OF IL-8 RECEPTORS, A PHARMACEUTICAL COMPOSITION CONTAINING THEM AND THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
AU2001250412A1 (en) * 2000-03-31 2001-10-08 Ipf Pharmaceuticals Gmbh Diagnostic and medicament for analysing the cell surface proteome of tumour and inflammatory cells and for treating tumorous and inflammatory diseases, preferably using specific chemokine receptor analysis and the chemokine receptor-ligand interaction
TW200418812A (en) 2002-10-29 2004-10-01 Smithkline Beecham Corp IL-8 receptor antagonists
JPWO2004074260A1 (en) * 2003-02-21 2006-06-01 協和醗酵工業株式会社 Pyrimidine derivatives
CA2565519A1 (en) 2004-05-12 2005-12-01 Schering Corporation Cxcr1 and cxcr2 chemokine antagonists
AU2007240364A1 (en) 2006-04-21 2007-11-01 Smithkline Beecham Corporation IL-8 receptor antagonists
UA98456C2 (en) 2006-04-21 2012-05-25 Смитклайн Бичам Корпорейшн Il-8 receptor antagonists

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0392802A2 (en) * 1989-04-11 1990-10-17 Beecham Group p.l.c. Preparation of urea analogues and their use in bronchial, cerebrovascular and neuronal disorders
WO1994004500A1 (en) * 1992-08-13 1994-03-03 The Upjohn Company Cyanoguanidines as potassium channel blockers
WO1994022807A1 (en) * 1993-04-07 1994-10-13 Neurosearch A/S Urea and amide derivatives and their use in the control of cell membrane potassium channels
WO1995007934A2 (en) * 1993-09-14 1995-03-23 Chiron Corporation Il8 inhibitors
EP0652228A1 (en) * 1993-05-12 1995-05-10 American Cyanamid Company Urethanes and ureas that induce cytokine production
WO1996025157A1 (en) * 1995-02-17 1996-08-22 Smithkline Beecham Corporation Il-8 receptor antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05294935A (en) * 1991-03-15 1993-11-09 Green Cross Corp:The Aminopyridine-based compound

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0392802A2 (en) * 1989-04-11 1990-10-17 Beecham Group p.l.c. Preparation of urea analogues and their use in bronchial, cerebrovascular and neuronal disorders
WO1994004500A1 (en) * 1992-08-13 1994-03-03 The Upjohn Company Cyanoguanidines as potassium channel blockers
WO1994004499A1 (en) * 1992-08-13 1994-03-03 The Upjohn Company Cyanoguanidines as potassium channel blockers
WO1994022807A1 (en) * 1993-04-07 1994-10-13 Neurosearch A/S Urea and amide derivatives and their use in the control of cell membrane potassium channels
EP0652228A1 (en) * 1993-05-12 1995-05-10 American Cyanamid Company Urethanes and ureas that induce cytokine production
WO1995007934A2 (en) * 1993-09-14 1995-03-23 Chiron Corporation Il8 inhibitors
WO1996025157A1 (en) * 1995-02-17 1996-08-22 Smithkline Beecham Corporation Il-8 receptor antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9806398A1 *

Also Published As

Publication number Publication date
JP2000516620A (en) 2000-12-12
WO1998006398A1 (en) 1998-02-19
EP0939634A1 (en) 1999-09-08

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