AR065249A1 - Derivados nitrogenados condensados de analogos de nucleosidos, composiciones farmaceuticas que los contienen y usos para tratar y/o prevenir infecciones virales. - Google Patents
Derivados nitrogenados condensados de analogos de nucleosidos, composiciones farmaceuticas que los contienen y usos para tratar y/o prevenir infecciones virales.Info
- Publication number
- AR065249A1 AR065249A1 ARP080100529A ARP080100529A AR065249A1 AR 065249 A1 AR065249 A1 AR 065249A1 AR P080100529 A ARP080100529 A AR P080100529A AR P080100529 A ARP080100529 A AR P080100529A AR 065249 A1 AR065249 A1 AR 065249A1
- Authority
- AR
- Argentina
- Prior art keywords
- nitrogenate
- condensed
- treat
- derivatives
- pharmaceutical compositions
- Prior art date
Links
- VZQXUWKZDSEQRR-UHFFFAOYSA-N Nucleosid Natural products C12=NC(SC)=NC(NCC=C(C)C)=C2N=CN1C1OC(CO)C(O)C1O VZQXUWKZDSEQRR-UHFFFAOYSA-N 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 nitro, hydroxyl Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de la formula (1), o una sal farmacéuticamente aceptable o profármaco del mismo; en donde X es CH o CR4; R1 es halogeno, NR5R6 u OR7; R2 es H, halogeno, o NR5R6; R3 es H, alquilo, alquenilo, alquinilo, arilo, cicloalquilo, heterocicloalquilo o heteroarilo, cada uno de los cuales está opcionalmente sustituido con uno o más sustituyentes; R4 es alquilo, alquenilo, alquinilo, arilo, cicloalquilo, heterocicloalquilo, heteroarilo, halogeno, ciano, nitro, hidroxilo, alcoxilo, tioalquilo, amino, alquilamino, carboxilo, carboxamida, o alquiloxicarbonilo, cada uno de los cuales está opcionalmente sustituido con uno o más sustituyentes; R5 y R6 se seleccionan independientemente a partir del grupo que consiste en H, alquilo, alquenilo, alquinilo, arilo, cicloalquilo, heterocicloalquilo, heteroarilo, amino, alquilamino, arilamino, hidroxilo, alcoxilo, arilcarbonilo y alquilcarbonilo, cada uno de los cuales está opcionalmente sustituido con uno o más sustituyentes; y R7 es H, alquilo, alquenilo, alquinilo, arilo, cicloalquilo, heterocicloalquilo, heteroarilo, alquilcarbonilo o arilcarbonilo cada uno de los cuales está opcionalmente sustituido con uno o más sustituyentes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07102027 | 2007-02-09 | ||
| EP08150003 | 2008-01-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR065249A1 true AR065249A1 (es) | 2009-05-27 |
Family
ID=39462074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080100529A AR065249A1 (es) | 2007-02-09 | 2008-02-07 | Derivados nitrogenados condensados de analogos de nucleosidos, composiciones farmaceuticas que los contienen y usos para tratar y/o prevenir infecciones virales. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8278282B2 (es) |
| EP (1) | EP2132216B1 (es) |
| JP (1) | JP2010518047A (es) |
| KR (1) | KR20090109102A (es) |
| CN (1) | CN101600726B (es) |
| AR (1) | AR065249A1 (es) |
| AT (1) | ATE533774T1 (es) |
| AU (1) | AU2008212752A1 (es) |
| BR (1) | BRPI0807222A2 (es) |
| CA (1) | CA2675462A1 (es) |
| CL (1) | CL2008000409A1 (es) |
| EA (1) | EA200901080A1 (es) |
| ES (1) | ES2381093T3 (es) |
| MX (1) | MX2009008495A (es) |
| PE (1) | PE20090070A1 (es) |
| PT (1) | PT2132216E (es) |
| TW (1) | TW200838550A (es) |
| WO (1) | WO2008095993A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR072906A1 (es) * | 2008-08-06 | 2010-09-29 | Novartis Ag | Nucleosidos modificados utiles como antivirales |
| CN102526087B (zh) * | 2010-12-30 | 2014-09-03 | 南开大学 | 核苷类化合物在制备治疗肠病毒71(ev71)感染疾病药物的应用 |
| CN105669783B (zh) * | 2014-12-03 | 2019-11-12 | 广东东阳光药业有限公司 | 一种制备呋喃糖的方法 |
| EA201890454A1 (ru) | 2015-08-06 | 2018-07-31 | Чимерикс, Инк. | Пирролопиримидиновые нуклеозиды и их аналоги, которые можно использовать в качестве противовирусных средств |
| JP6768796B2 (ja) | 2015-09-23 | 2020-10-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ４’−置換ヌクレオシド逆転写酵素阻害剤及びその調製 |
| EP3448392A4 (en) * | 2016-04-28 | 2020-01-15 | Emory University | ALKYNOUS THERAPEUTIC NUCLEOTIDE AND NUCLEOSIDE COMPOSITIONS AND RELATED APPLICATIONS |
| TW201815821A (zh) * | 2016-07-18 | 2018-05-01 | 美商再生元醫藥公司 | 抗茲卡病毒抗體及使用方法 |
| TW201811339A (zh) * | 2016-08-12 | 2018-04-01 | 美商艾洛斯生物製藥公司 | 經取代之核苷、核苷酸及其類似物 |
| ES3011607T3 (en) | 2017-09-21 | 2025-04-07 | Chimerix Inc | Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7h-pyrrolo(2,3-d)pyrimidine-5-carboxamide and uses thereof |
| WO2020219447A1 (en) | 2019-04-23 | 2020-10-29 | Elementis Specialties, Inc. | Slurry compositions containing mixed branched alkyl organoclay compositions |
| EP4454650A4 (en) * | 2021-12-22 | 2025-10-22 | Cj Cheiljedang Corp | ANTIVIRAL COMPOSITION COMPRISING NUCLEOSIDE ANALOGUES DERIVED FROM A NUCLEIC ACID AND A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF |
| WO2024012568A1 (en) * | 2022-07-15 | 2024-01-18 | Sunshine Lake Pharma Co., Ltd. | A key intermediate for preparing glucopyranosyl derivatives and preparation method thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1355916T1 (sl) * | 2001-01-22 | 2007-04-30 | Merck & Co Inc | Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze |
| CA2469663A1 (en) * | 2001-12-14 | 2003-06-26 | Alcon, Inc. | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma |
| AU2003209045B2 (en) | 2002-02-13 | 2006-12-14 | Isis Pharmaceuticals, Inc. | Methods of inhibiting orthopoxvirus replication with nucleoside compounds |
| AU2003232071A1 (en) * | 2002-05-06 | 2003-11-17 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
| TW200418498A (en) * | 2002-09-30 | 2004-10-01 | Genelabs Tech Inc | Nucleoside derivatives for treating hepatitis C virus infection |
| US20040259934A1 (en) * | 2003-05-01 | 2004-12-23 | Olsen David B. | Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds |
| WO2005042556A1 (en) * | 2003-10-27 | 2005-05-12 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
-
2008
- 2008-02-05 TW TW097104689A patent/TW200838550A/zh unknown
- 2008-02-07 EP EP08708805A patent/EP2132216B1/en not_active Not-in-force
- 2008-02-07 AR ARP080100529A patent/AR065249A1/es unknown
- 2008-02-07 PT PT08708805T patent/PT2132216E/pt unknown
- 2008-02-07 AT AT08708805T patent/ATE533774T1/de active
- 2008-02-07 EA EA200901080A patent/EA200901080A1/ru unknown
- 2008-02-07 BR BRPI0807222-1A2A patent/BRPI0807222A2/pt not_active IP Right Cessation
- 2008-02-07 PE PE2008000274A patent/PE20090070A1/es not_active Application Discontinuation
- 2008-02-07 KR KR1020097016580A patent/KR20090109102A/ko not_active Ceased
- 2008-02-07 AU AU2008212752A patent/AU2008212752A1/en not_active Abandoned
- 2008-02-07 CN CN2008800031040A patent/CN101600726B/zh not_active Expired - Fee Related
- 2008-02-07 WO PCT/EP2008/051527 patent/WO2008095993A1/en not_active Ceased
- 2008-02-07 US US12/526,079 patent/US8278282B2/en not_active Expired - Fee Related
- 2008-02-07 ES ES08708805T patent/ES2381093T3/es active Active
- 2008-02-07 CA CA002675462A patent/CA2675462A1/en not_active Abandoned
- 2008-02-07 JP JP2009548691A patent/JP2010518047A/ja active Pending
- 2008-02-07 MX MX2009008495A patent/MX2009008495A/es active IP Right Grant
- 2008-02-08 CL CL200800409A patent/CL2008000409A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE533774T1 (de) | 2011-12-15 |
| CN101600726A (zh) | 2009-12-09 |
| MX2009008495A (es) | 2009-08-20 |
| EP2132216A1 (en) | 2009-12-16 |
| WO2008095993A1 (en) | 2008-08-14 |
| EA200901080A1 (ru) | 2010-02-26 |
| ES2381093T3 (es) | 2012-05-23 |
| EP2132216B1 (en) | 2011-11-16 |
| PE20090070A1 (es) | 2009-03-19 |
| TW200838550A (en) | 2008-10-01 |
| CA2675462A1 (en) | 2008-08-14 |
| US8278282B2 (en) | 2012-10-02 |
| CN101600726B (zh) | 2013-03-27 |
| AU2008212752A1 (en) | 2008-08-14 |
| CL2008000409A1 (es) | 2008-08-29 |
| US20100227833A1 (en) | 2010-09-09 |
| KR20090109102A (ko) | 2009-10-19 |
| JP2010518047A (ja) | 2010-05-27 |
| PT2132216E (pt) | 2012-02-20 |
| BRPI0807222A2 (pt) | 2014-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |