PL2155758T3 - Pochodne tetrahydrofuro[3,4-d]dioksolanu przeznaczone do stosowania w leczeniu infekcji wirusowych i raka - Google Patents
Pochodne tetrahydrofuro[3,4-d]dioksolanu przeznaczone do stosowania w leczeniu infekcji wirusowych i rakaInfo
- Publication number
- PL2155758T3 PL2155758T3 PL08747850T PL08747850T PL2155758T3 PL 2155758 T3 PL2155758 T3 PL 2155758T3 PL 08747850 T PL08747850 T PL 08747850T PL 08747850 T PL08747850 T PL 08747850T PL 2155758 T3 PL2155758 T3 PL 2155758T3
- Authority
- PL
- Poland
- Prior art keywords
- tetrahydrofuro
- cancer
- treatment
- viral infections
- dioxolane compounds
- Prior art date
Links
- VFHZTMDFXALDLD-UHFFFAOYSA-N 3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxole Chemical class C1OCC2OCOC21 VFHZTMDFXALDLD-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000009385 viral infection Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91721007P | 2007-05-10 | 2007-05-10 | |
| US94012507P | 2007-05-25 | 2007-05-25 | |
| PCT/US2008/063037 WO2008141079A1 (en) | 2007-05-10 | 2008-05-08 | Tetrahydrofuro [3 4-d] dioxolane compounds for use in the treatment of viral infections and cancer |
| EP08747850A EP2155758B1 (en) | 2007-05-10 | 2008-05-08 | Tetrahydrofuro[3,4-d]dioxolane compounds for use in the treatment of viral infections and cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2155758T3 true PL2155758T3 (pl) | 2013-06-28 |
Family
ID=39639610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08747850T PL2155758T3 (pl) | 2007-05-10 | 2008-05-08 | Pochodne tetrahydrofuro[3,4-d]dioksolanu przeznaczone do stosowania w leczeniu infekcji wirusowych i raka |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8242085B2 (pl) |
| EP (1) | EP2155758B1 (pl) |
| JP (1) | JP2011513195A (pl) |
| AU (1) | AU2008251555B2 (pl) |
| CA (1) | CA2685520A1 (pl) |
| CY (1) | CY1113323T1 (pl) |
| DK (1) | DK2155758T3 (pl) |
| ES (1) | ES2393038T3 (pl) |
| HR (1) | HRP20120914T1 (pl) |
| PL (1) | PL2155758T3 (pl) |
| PT (1) | PT2155758E (pl) |
| WO (1) | WO2008141079A1 (pl) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2155758T3 (pl) | 2007-05-10 | 2013-06-28 | Biocryst Pharm Inc | Pochodne tetrahydrofuro[3,4-d]dioksolanu przeznaczone do stosowania w leczeniu infekcji wirusowych i raka |
| TW200942243A (en) | 2008-03-05 | 2009-10-16 | Biocryst Pharm Inc | Antiviral therapeutic agents |
| US20090247750A1 (en) * | 2008-03-28 | 2009-10-01 | Biocryst Pharmaceuticals, Inc. | Process for preparing nucleoside analogs |
| RS54008B1 (sr) | 2008-04-23 | 2015-10-30 | Gilead Sciences Inc. | 1`-supstituisani karba-nukleozidni analozi za antivirusnu terapiju |
| WO2010036407A2 (en) * | 2008-05-15 | 2010-04-01 | Biocryst Pharmaceuticals, Inc. | Antiviral nucleoside analogs |
| EP2313102A2 (en) | 2008-07-03 | 2011-04-27 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
| KR101724759B1 (ko) | 2009-02-10 | 2017-04-07 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 치료를 위한 카르바-뉴클레오시드 유사체 |
| US8455451B2 (en) * | 2009-09-21 | 2013-06-04 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| WO2011035250A1 (en) | 2009-09-21 | 2011-03-24 | Gilead Sciences, Inc. | Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs |
| BR112012006261B1 (pt) | 2009-09-21 | 2021-12-21 | Gilead Sciences, Inc | Compostos análogos de 2'-flúor substituído carbanucleosídeo, composto útil para a preparação do mesmo, composição farmacêutica e uso dos compostos análogos de 2'-flúor substituído carbanucleosídeo |
| US7973013B2 (en) | 2009-09-21 | 2011-07-05 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| EA020847B1 (ru) | 2009-10-30 | 2015-02-27 | Янссен Фармацевтика Нв | ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-b]ПИРИДАЗИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ PDE10 |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| TW201201815A (en) * | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
| US9090642B2 (en) | 2010-07-19 | 2015-07-28 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
| CR20170278A (es) | 2010-07-22 | 2017-09-29 | Gilead Sciences Inc | Métodos y compuestos para tratar infecciones virales por paramyxoviridae |
| TW201305185A (zh) | 2010-09-13 | 2013-02-01 | Gilead Sciences Inc | 用於抗病毒治療之2’-氟取代之碳-核苷類似物 |
| JP2013538230A (ja) | 2010-09-20 | 2013-10-10 | ギリアード サイエンシーズ, インコーポレイテッド | 抗ウイルス治療用の2’−フルオロ置換カルバヌクレオシド類似体 |
| US8877733B2 (en) | 2011-04-13 | 2014-11-04 | Gilead Sciences, Inc. | 1′-substituted pyrimidine N-nucleoside analogs for antiviral treatment |
| BR112013033375B1 (pt) | 2011-06-27 | 2022-05-10 | Janssen Pharmaceutica N.V | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário |
| CA2752008A1 (en) | 2011-09-13 | 2013-03-13 | Universite De Montreal | Combination therapy using ribavirin as elf4e inhibitor |
| EP2834258B1 (en) * | 2012-03-13 | 2017-01-04 | Gilead Sciences, Inc. | 2'- substituted carba-nucleoside analogs for antiviral treatment |
| ES2855575T3 (es) | 2012-06-26 | 2021-09-23 | Janssen Pharmaceutica Nv | Combinaciones que comprenden compuestos de 4-metil-[1,2,4]triazolo[4,3-a]quinoxalina como inhibidores de PDE2 e inhibidores de PDE10 para su uso en el tratamiento de trastornos neurológicos o metabólicos |
| JP6174695B2 (ja) | 2012-07-09 | 2017-08-02 | ヤンセン ファーマシューティカ エヌ.ベー. | ホスホジエステラーゼ10酵素の阻害剤 |
| EP3251674A3 (en) * | 2012-11-16 | 2018-02-21 | BioCryst Pharmaceuticals, Inc. | Antiviral azasugar-containing nucleosides |
| UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| TWI678369B (zh) * | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並[3,2-d]嘧啶、呋喃並[3,2-d]嘧啶及吡咯並[3,2-d]嘧啶化合物類 |
| TWI673283B (zh) | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | 2’-氯胺基嘧啶酮及嘧啶二酮核苷類 |
| TWI767201B (zh) | 2014-10-29 | 2022-06-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| DK3265102T3 (da) | 2015-03-06 | 2025-10-13 | Atea Pharmaceuticals Inc | Beta-d-2'-deoxy-2'alpha-fluoro-2'-beta-c-substituerede-2-modificerede-n6-substituerede purinnukleotider til hcv-behandling |
| PL3349758T3 (pl) | 2015-09-16 | 2022-09-12 | Gilead Sciences, Inc. | Sposoby leczenia zakażeń wirusami arenaviridae |
| IL293496B2 (en) | 2016-03-28 | 2023-05-01 | Incyte Corp | Pyrrolotriazine compounds as TAM inhibitors |
| US10711029B2 (en) | 2016-07-14 | 2020-07-14 | Atea Pharmaceuticals, Inc. | Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| SMT202200072T1 (it) | 2016-09-07 | 2022-03-21 | Atea Pharmaceuticals Inc | Nucleotidi purinici 2'-sostituiti-n6-sostituiti per il trattamento dei virus rna |
| US10519186B2 (en) | 2017-02-01 | 2019-12-31 | Atea Pharmaceuticals, Inc. | Nucleotide hemi-sulfate salt for the treatment of hepatitis C virus |
| CN110869028B (zh) | 2017-03-14 | 2023-01-20 | 吉利德科学公司 | 治疗猫冠状病毒感染的方法 |
| US10836787B2 (en) | 2017-05-01 | 2020-11-17 | Gilead Sciences, Inc. | Crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5- (4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| ES3000461T3 (en) | 2017-07-11 | 2025-02-28 | Gilead Sciences Inc | Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections |
| CN112351799A (zh) | 2018-04-10 | 2021-02-09 | 阿堤亚制药公司 | 具有硬化的hcv感染患者的治疗 |
| CN114641299A (zh) | 2020-01-27 | 2022-06-17 | 吉利德科学公司 | 用于治疗SARS CoV-2感染的方法 |
| CN113214262B (zh) * | 2020-02-05 | 2023-07-07 | 华创合成制药股份有限公司 | 一种含有胍基的化合物及其制备方法和用途 |
| TWI874791B (zh) | 2020-02-18 | 2025-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI884403B (zh) | 2020-02-18 | 2025-05-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI883391B (zh) | 2020-02-18 | 2025-05-11 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| AU2021224588B2 (en) | 2020-02-18 | 2024-07-18 | Gilead Sciences, Inc. | Antiviral compounds |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| CA3169340A1 (en) | 2020-03-12 | 2021-09-16 | Pavel R. Badalov | Methods of preparing 1'-cyano nucleosides |
| EP4132651B1 (en) | 2020-04-06 | 2026-03-18 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
| ES3041698T3 (en) | 2020-05-29 | 2025-11-13 | Gilead Sciences Inc | Remdesivir for the treatment of viral infections |
| US11939347B2 (en) | 2020-06-24 | 2024-03-26 | Gilead Sciences, Inc. | 1′-cyano nucleoside analogs and uses thereof |
| DK4204421T3 (da) | 2020-08-27 | 2024-05-27 | Gilead Sciences Inc | Forbindelser og fremgangsmåder til behandling af virale infektioner |
| EP4323362B1 (en) | 2021-04-16 | 2025-05-07 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| BR112023026356A2 (pt) | 2021-06-17 | 2024-03-05 | Atea Pharmaceuticals Inc | Método para tratar vírus da hepatite c ou uma condição resultante de uma infecção por hepatite c, combinação, uso da combinação, composição farmacêutica, e, kit para o tratamento de vírus da hepatite c |
| JP7719954B2 (ja) | 2021-08-18 | 2025-08-06 | ギリアード サイエンシーズ, インコーポレイテッド | リン脂質化合物並びにその製造方法及び使用方法 |
| JPWO2023022216A1 (pl) | 2021-08-20 | 2023-02-23 | ||
| MX2024010591A (es) | 2022-03-02 | 2024-09-06 | Gilead Sciences Inc | Compuestos y metodos para el tratamiento de infecciones virales. |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL156641A0 (en) * | 2001-01-22 | 2004-01-04 | Merck & Co Inc | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| CA2456292A1 (en) * | 2001-08-14 | 2003-02-27 | Toyama Chemical Co., Ltd. | Novel virus growth inhibitor and/or virucidal method, and novel pyrazine nucleotide or pirazine nucleoside analog |
| JP2007504152A (ja) * | 2003-08-27 | 2007-03-01 | ビオタ, インコーポレイテッド | 治療剤としての新規三環ヌクレオシドまたはヌクレオチド |
| AU2005254057B2 (en) * | 2004-06-15 | 2011-02-17 | Isis Pharmaceuticals, Inc. | C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase |
| US7560434B2 (en) * | 2004-06-22 | 2009-07-14 | Biocryst Pharmaceuticals, Inc. | AZA nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| JP5089395B2 (ja) * | 2004-10-29 | 2012-12-05 | バイオクライスト ファーマシューティカルズ, インコーポレイテッド | 治療用フロピリミジンおよびチエノピリミジン |
| JP5107228B2 (ja) * | 2005-03-29 | 2012-12-26 | バイオクライスト ファーマシューティカルズ, インコーポレイテッド | C型肝炎治療 |
| US8344132B2 (en) * | 2005-06-22 | 2013-01-01 | BioCryst Pharmaceticals, Inc. | Methods for the preparation of 9-deazapurine derivatives |
| WO2007021610A2 (en) | 2005-08-09 | 2007-02-22 | Merck & Co., Inc. | Ribonucleoside cyclic acetal derivatives for the treatment of rna-dependent rna viral infection |
| CA2674589A1 (en) * | 2007-01-12 | 2008-07-24 | Biocryst Pharmaceuticals, Inc. | Antiviral nucleoside analogs |
| PL2155758T3 (pl) | 2007-05-10 | 2013-06-28 | Biocryst Pharm Inc | Pochodne tetrahydrofuro[3,4-d]dioksolanu przeznaczone do stosowania w leczeniu infekcji wirusowych i raka |
| TW200942243A (en) * | 2008-03-05 | 2009-10-16 | Biocryst Pharm Inc | Antiviral therapeutic agents |
| WO2009116335A1 (ja) * | 2008-03-19 | 2009-09-24 | 日東電工株式会社 | 親水性シートおよび基材表面の超親水化方法 |
| US20090247750A1 (en) * | 2008-03-28 | 2009-10-01 | Biocryst Pharmaceuticals, Inc. | Process for preparing nucleoside analogs |
| CA2731228A1 (en) | 2008-07-22 | 2010-01-28 | Biocryst Pharmaceuticals, Inc. | Synthetic intermediates and processes |
-
2008
- 2008-05-08 PL PL08747850T patent/PL2155758T3/pl unknown
- 2008-05-08 US US12/599,656 patent/US8242085B2/en active Active
- 2008-05-08 DK DK08747850.9T patent/DK2155758T3/da active
- 2008-05-08 PT PT08747850T patent/PT2155758E/pt unknown
- 2008-05-08 AU AU2008251555A patent/AU2008251555B2/en not_active Ceased
- 2008-05-08 EP EP08747850A patent/EP2155758B1/en not_active Not-in-force
- 2008-05-08 WO PCT/US2008/063037 patent/WO2008141079A1/en not_active Ceased
- 2008-05-08 JP JP2010507652A patent/JP2011513195A/ja active Pending
- 2008-05-08 CA CA002685520A patent/CA2685520A1/en not_active Abandoned
- 2008-05-08 ES ES08747850T patent/ES2393038T3/es active Active
- 2008-05-08 HR HRP20120914AT patent/HRP20120914T1/hr unknown
-
2012
- 2012-11-09 CY CY20121101070T patent/CY1113323T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2685520A1 (en) | 2008-11-20 |
| PT2155758E (pt) | 2012-11-12 |
| CY1113323T1 (el) | 2016-06-22 |
| HRP20120914T1 (hr) | 2012-12-31 |
| EP2155758A1 (en) | 2010-02-24 |
| ES2393038T3 (es) | 2012-12-18 |
| DK2155758T3 (da) | 2012-11-05 |
| EP2155758B1 (en) | 2012-08-22 |
| HK1139656A1 (en) | 2010-09-24 |
| AU2008251555A1 (en) | 2008-11-20 |
| US20110002886A1 (en) | 2011-01-06 |
| WO2008141079A1 (en) | 2008-11-20 |
| AU2008251555B2 (en) | 2012-08-30 |
| US8242085B2 (en) | 2012-08-14 |
| JP2011513195A (ja) | 2011-04-28 |
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