HRP20220740T1 - Postupci za liječenje virusnih infekcija arenaviridae - Google Patents
Postupci za liječenje virusnih infekcija arenaviridae Download PDFInfo
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- HRP20220740T1 HRP20220740T1 HRP20220740TT HRP20220740T HRP20220740T1 HR P20220740 T1 HRP20220740 T1 HR P20220740T1 HR P20220740T T HRP20220740T T HR P20220740TT HR P20220740 T HRP20220740 T HR P20220740T HR P20220740 T1 HRP20220740 T1 HR P20220740T1
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- 241000712892 Arenaviridae Species 0.000 title claims 2
- 230000009385 viral infection Effects 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 4
- 208000005989 Arenaviridae Infections Diseases 0.000 claims 4
- 229950008454 favipiravir Drugs 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- ZCGNOVWYSGBHAU-UHFFFAOYSA-N favipiravir Chemical compound NC(=O)C1=NC(F)=CNC1=O ZCGNOVWYSGBHAU-UHFFFAOYSA-N 0.000 claims 3
- 125000006736 (C6-C20) aryl group Chemical group 0.000 claims 2
- 241000712902 Lassa mammarenavirus Species 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 1
- 229940121786 Beta 2 adrenoreceptor agonist Drugs 0.000 claims 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 1
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 1
- 241000712890 Junin mammarenavirus Species 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- -1 T-705 monophosphate Chemical class 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 229940124630 bronchodilator Drugs 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 239000001177 diphosphate Substances 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003172 expectorant agent Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229940066491 mucolytics Drugs 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000001226 triphosphate Substances 0.000 claims 1
- 235000011178 triphosphate Nutrition 0.000 claims 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (15)
1. Spoj, naznačen time, da je predstavljen Formulom IV:
[image]
ili njegova farmaceutski prihvatljiva sol, za uporabu u liječenju infekcije Arenaviridae kod čovjeka kojemu je to potrebno, pri čemu:
R7 se bira iz skupine koju čine:
a) H,
b)
[image]
c)
[image]
gdje:
Rc se bira od fenila, 1-naftila, 2-naftila,
[image]
Rd je H ili CH3;
svaki od Re1 i Re2 je neovisno H, (C1-C6)alkil ili benzil; i
Rf se bira od H, (C1-C8)alkila, benzila, (C3-C6)cikloalkila, i -CH2-(C3-C6)cikloalkila; ili
d)
[image]
gdje:
R je H, (C1-C8)alkil, (C2-C8)alkenil, (C2-C8)alkinil, (C6-C20)aril, (C2-C20)heterociklil, ili (C6-C20)aril(C1-C8)alkil.
2. Spoj za uporabu prema patentnom zahtjevu 1, naznačen time, da:
svaki od Re1 i Re2 je neovisno H ili C1-C6 alkil.
3. Spoj za uporabu prema patentnom zahtjevu 1, naznačen time, da
R7 je:
[image]
4. Spoj za uporabu prema patentnom zahtjevu 1, naznačen time, da
R7 je:
[image]
pri čemu Rf je (C1-C8)alkil.
5. Spoj za uporabu prema patentnom zahtjevu 1, naznačen time, da
R7 je:
[image]
[image]
6. Spoj za uporabu prema patentnom zahtjevu 1, naznačen time, da
se R7 bira iz skupine koju čine:
[image]
7. Spoj za uporabu prema patentnom zahtjevu 1, naznačen time, da
R7 je:
[image]
[image]
[image]
8. Spoj za uporabu prema patentnom zahtjevu 1, naznačen time, da spoj Formule IV je:
[image]
[image]
ili
[image]
ili njegova farmaceutski prihvatljiva sol.
9. Spoj za uporabu prema patentnom zahtjevu 1, naznačen time, da spoj Formule IV je:
[image]
[image]
[image]
[image]
[image]
[image]
ili
[image]
ili njegova farmaceutski prihvatljiva sol.
10. Spoj za uporabu prema patentnom zahtjevu 1, naznačen time, da spoj Formule IV je:
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
ili njegova farmaceutski prihvatljiva sol.
11. Spoj za uporabu prema patentnom zahtjevu 1, naznačen time, da spoj Formule IV je:
[image]
ili njegova farmaceutski prihvatljiva sol.
12. Spoj za uporabu prema patentnom zahtjevu 1, naznačen time, da spoj Formule IV je:
[image]
ili njegova farmaceutski prihvatljiva sol.
13. Spoj za uporabu prema bilo kojem od patentnih zahtjeva 1-12, naznačen time, da:
(i) spoj Formule IV je za uporabu s najmanje jednim drugačijim terapijskim sredstvom ili njegovim pripravkom, pri čemu se najmanje jedno drugačije terapijsko sredstvo bira iz skupine koju čine kortikosteroid, protuupalni modulator transdukcijskog signala, β2-adrenoreceptorski agonist - bronhodilatator, antikolinergijsko sredstvo, mukolitičko sredstvo, hipertonična slana otopina, i ostali lijekovi za liječenje virusnih infekcija Arenaviridae; ili njihove mješavine; ili
(ii) spoj Formule IV je za uporabu s najmanje jednim drugačijim terapijskim sredstvom ili njegovim pripravkom, pri čemu se najmanje jedno drugačije terapijsko sredstvo bira iz skupine koju čine ribavirin, favipiravir (također poznat kao T-705), T-705 monofosfat, T-705 difosfat, T-705 trifosfat, ST-193, i njihove mješavine.
14. Spoj za uporabu prema bilo kojem od patentnih zahtjeva 1-13, naznačen time, da:
(i) infekcija Arenaviridae je uzrokovana Lassa virusom; ili
(ii) infekcija Arenaviridae je uzrokovana Junin virusom.
15. Spoj za uporabu prema patentnom zahtjevu 14, naznačen time, da infekcija Arenaviridae je uzrokovana sojem Lassa virusa koji je odabran iz skupine koju čine Josiah, NL, z 148, Macenta, AV, i CSF.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562219302P | 2015-09-16 | 2015-09-16 | |
US201562239696P | 2015-10-09 | 2015-10-09 | |
PCT/US2016/052092 WO2017049060A1 (en) | 2015-09-16 | 2016-09-16 | Methods for treating arenaviridae and coronaviridae virus infections |
EP16770866.8A EP3349758B1 (en) | 2015-09-16 | 2016-09-16 | Methods for treating arenaviridae virus infections |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20220740T1 true HRP20220740T1 (hr) | 2022-11-11 |
Family
ID=56997582
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20220740TT HRP20220740T1 (hr) | 2015-09-16 | 2016-09-16 | Postupci za liječenje virusnih infekcija arenaviridae |
HRP20220355TT HRP20220355T1 (hr) | 2015-09-16 | 2016-09-16 | Postupci za liječenje infekcija coronaviridae |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20220355TT HRP20220355T1 (hr) | 2015-09-16 | 2016-09-16 | Postupci za liječenje infekcija coronaviridae |
Country Status (24)
Country | Link |
---|---|
US (5) | US10251904B2 (hr) |
EP (3) | EP3349758B1 (hr) |
JP (5) | JP6742403B2 (hr) |
KR (1) | KR20180050742A (hr) |
CN (5) | CN115844896A (hr) |
AU (3) | AU2016323604B2 (hr) |
BR (2) | BR122020020217B1 (hr) |
CA (1) | CA2998189C (hr) |
CY (1) | CY1125089T1 (hr) |
DK (2) | DK3785717T3 (hr) |
EA (1) | EA038141B1 (hr) |
ES (2) | ES2909419T3 (hr) |
HK (3) | HK1255732A1 (hr) |
HR (2) | HRP20220740T1 (hr) |
HU (2) | HUE057928T2 (hr) |
LT (2) | LT3349758T (hr) |
MA (2) | MA42819A (hr) |
MX (2) | MX2018003161A (hr) |
PL (2) | PL3785717T3 (hr) |
PT (2) | PT3349758T (hr) |
SG (2) | SG10202001878WA (hr) |
SI (2) | SI3349758T1 (hr) |
TW (1) | TW201733595A (hr) |
WO (1) | WO2017049060A1 (hr) |
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KR101848099B1 (ko) | 2009-09-21 | 2018-04-11 | 길리애드 사이언시즈, 인코포레이티드 | 1'-치환된 카바-뉴클레오사이드 유사체의 제조를 위한 방법 및 중간체 |
BR112013001553B1 (pt) | 2010-07-22 | 2021-01-12 | Gilead Sciences, Inc. | compostos antivirais para o tratamento de infecções por paramyxoviridae e composições farmacêuticas que os compreendem |
TWI698444B (zh) | 2014-10-29 | 2020-07-11 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
HRP20211456T1 (hr) | 2014-12-26 | 2021-12-24 | Emory University | Protuvirusni derivati n4-hidroksicitidina |
PL3785717T3 (pl) | 2015-09-16 | 2022-05-02 | Gilead Sciences, Inc. | Sposoby leczenia infekcji coronaviridae |
WO2018089306A1 (en) | 2016-11-10 | 2018-05-17 | Oyagen, Inc. | Methods of treating and inhibiting ebola virus infection |
EP3595672B1 (en) | 2017-03-14 | 2023-09-06 | Gilead Sciences, Inc. | Compounds for use in methods of treating feline coronavirus infections |
AR111490A1 (es) | 2017-05-01 | 2019-07-17 | Gilead Sciences Inc | Formas cristalinas de propanoato de (s)-2-etilbutil 2-(((s)-(((2r,3s,4r,5r)-5-(4-aminopirrolo[2,1-f][1,2,4]triazin-7-il)-5-ciano-3,4-dihidroxitetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino) |
TW201919648A (zh) * | 2017-07-11 | 2019-06-01 | 美商基利科學股份有限公司 | 用於治療病毒感染之含rna聚合酶抑制劑與環糊精的組合物 |
US11149049B2 (en) * | 2017-09-18 | 2021-10-19 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
JP6804790B1 (ja) | 2017-12-07 | 2020-12-23 | エモリー ユニバーシティー | N4−ヒドロキシシチジンおよび誘導体ならびにそれらに関連する抗ウイルス用途 |
CN110724174B (zh) * | 2019-09-10 | 2021-02-05 | 广州六顺生物科技股份有限公司 | 吡咯并三嗪类化合物、组合物及其应用 |
CN111265532A (zh) * | 2020-01-21 | 2020-06-12 | 中国人民解放军军事科学院军事医学研究院 | 取代氨基丙酸酯类化合物在治疗2019-nCoV感染中的应用 |
KR20220132608A (ko) * | 2020-01-27 | 2022-09-30 | 길리애드 사이언시즈, 인코포레이티드 | SARS CoV-2 감염증을 치료하기 위한 방법 |
WO2021158248A1 (en) | 2020-02-04 | 2021-08-12 | Oyagen, Inc. | Method for treating coronavirus infections |
TWI775313B (zh) * | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
EP4106876A1 (en) | 2020-02-18 | 2022-12-28 | Gilead Sciences, Inc. | Antiviral compounds |
TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
CN113292565B (zh) * | 2020-02-24 | 2023-01-31 | 浙江森科建设有限公司 | 核苷类化合物及其制备方法和应用 |
WO2021168930A1 (zh) * | 2020-02-25 | 2021-09-02 | 顾世海 | 一种瑞德西韦的片剂及其制备方法 |
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CN111233929B (zh) * | 2020-02-28 | 2023-02-28 | 成都阿奇生物医药科技有限公司 | 一种核苷类似物的氘代物及其制备方法和用途 |
WO2021175250A1 (en) * | 2020-03-03 | 2021-09-10 | Aptorum Therapeutics Limited | Compounds and methods for treating diseases and/or conditions caused by coronavirus |
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