MX2013008359A - Aminas de c-28 de derivados de acido betulinico modificado de c-3 como inhibidores de la maduracion del virus de inmunodeficiencia humana. - Google Patents

Aminas de c-28 de derivados de acido betulinico modificado de c-3 como inhibidores de la maduracion del virus de inmunodeficiencia humana.

Info

Publication number
MX2013008359A
MX2013008359A MX2013008359A MX2013008359A MX2013008359A MX 2013008359 A MX2013008359 A MX 2013008359A MX 2013008359 A MX2013008359 A MX 2013008359A MX 2013008359 A MX2013008359 A MX 2013008359A MX 2013008359 A MX2013008359 A MX 2013008359A
Authority
MX
Mexico
Prior art keywords
amines
acid derivatives
betulinic acid
maturation inhibitors
compound
Prior art date
Application number
MX2013008359A
Other languages
English (en)
Inventor
Sing-Yuen Sit
Alicia Regueiro-Ren
Nicholas A Meanwell
Jacob Swidorski
Zheng Liu
Yan Chen
Jie Chen
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2013008359A publication Critical patent/MX2013008359A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a compuestos que tienen propiedades bio-afectación y de fármaco, sus composiciones farmacéuticas y métodos de uso. En particular, las aminas de C-28 de derivados de ácido betulínico modificado de C-3 que poseen actividad antiviral única son proporcionadas como inhibidores de la maduración del VIH. Estos compuestos son útiles para el tratamiento del VIH y SIDA. En particular, se proporcionan en la presente los siguientes compuestos, que incluye sales del mismo farmacéuticamente aceptables: un compuesto de fórmula (I), un compuesto de fórmula (II), y un compuesto de fórmula (III).
MX2013008359A 2011-01-31 2012-01-27 Aminas de c-28 de derivados de acido betulinico modificado de c-3 como inhibidores de la maduracion del virus de inmunodeficiencia humana. MX2013008359A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161437870P 2011-01-31 2011-01-31
PCT/US2012/022847 WO2012106188A1 (en) 2011-01-31 2012-01-27 C-28 amines of c-3 modified betulinic acid derivatives as hiv maturation inhibitors

Publications (1)

Publication Number Publication Date
MX2013008359A true MX2013008359A (es) 2013-08-27

Family

ID=45567146

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013008359A MX2013008359A (es) 2011-01-31 2012-01-27 Aminas de c-28 de derivados de acido betulinico modificado de c-3 como inhibidores de la maduracion del virus de inmunodeficiencia humana.

Country Status (19)

Country Link
US (1) US8748415B2 (es)
EP (1) EP2670764B1 (es)
JP (1) JP6000283B2 (es)
CN (1) CN103339141B (es)
BR (1) BR112014010105A2 (es)
CA (1) CA2826257A1 (es)
CY (1) CY1116989T1 (es)
DK (1) DK2670764T3 (es)
EA (1) EA023578B1 (es)
ES (1) ES2552512T3 (es)
HR (1) HRP20151212T1 (es)
HU (1) HUE026371T2 (es)
MX (1) MX2013008359A (es)
PL (1) PL2670764T3 (es)
PT (1) PT2670764E (es)
RS (1) RS54352B1 (es)
SI (1) SI2670764T1 (es)
SM (1) SMT201500303B (es)
WO (1) WO2012106188A1 (es)

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US8889854B2 (en) * 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
RU2516952C1 (ru) * 2012-11-09 2014-05-20 Леонид Леонидович Клопотенко Фармацевтическая композиция, содержащая инкапсулированную тритерпеновую кислоту или ее производные
RU2519133C1 (ru) * 2012-11-09 2014-06-10 Леонид Леонидович Клопотенко Мазь, содержащая инкапсулированную тритерпеновую кислоту или ее производные
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EP2953960A1 (en) * 2013-02-06 2015-12-16 Bristol-Myers Squibb Company C-19 modified triterpenoids with hiv maturation inhibitory activity
CN105102468A (zh) 2013-02-25 2015-11-25 百时美施贵宝公司 用于治疗hiv的c-3烷基和烯基修饰的桦木酸衍生物
CA2944778C (en) 2014-04-11 2022-06-14 ViiV Healthcare UK (No.4) Limited Triterpenoids with hiv maturation inhibitory activity
WO2015195776A1 (en) * 2014-06-19 2015-12-23 Bristol-Myers Squibb Company Betulinic acid derivatives with hiv maturation inhibitory activity
KR20170092581A (ko) 2014-11-14 2017-08-11 비브 헬스케어 유케이 (넘버5) 리미티드 Ｃ１７-아릴 치환된 베툴린산 유사체
AU2015346314B2 (en) * 2014-11-14 2018-04-12 VIIV Healthcare UK (No.5) Limited Extended betulinic acid analogs
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AU2016248235A1 (en) * 2015-04-14 2017-10-19 Viiv Healthcare Uk (No 4) Limited Crystalline forms of modified triterpenoid hydrochloride salts with HIV maturation inhibitor activity
KR20180028534A (ko) 2015-07-28 2018-03-16 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Hiv 감염을 예방하거나 치료하기 위한 베투인 유도체
CN108026139A (zh) * 2015-07-28 2018-05-11 葛兰素史克知识产权第二有限公司 用于预防或治疗hiv感染的白桦脂醇衍生物
KR20180054826A (ko) 2015-09-24 2018-05-24 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Hiv 성숙 억제 활성을 갖는 화합물
EP3405474A1 (en) 2016-01-20 2018-11-28 Glaxosmithkline Intellectual Property (No. 2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
EP3478703A1 (en) * 2016-06-30 2019-05-08 ViiV Healthcare UK (No.5) Limited Triterpenoid inhibitors of human immunodeficiency virus replication
KR20200052925A (ko) * 2017-09-13 2020-05-15 엠욘 인코퍼레이티드 우르솔산 모르폴린 및 디에탄올아민 염
CN111417384A (zh) 2017-09-14 2020-07-14 菲尼克斯生物技术公司 用于治疗神经系统病况的方法和改进的神经保护性组合物
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EP4321164A3 (en) 2018-04-24 2024-04-17 ViiV Healthcare UK (No.5) Limited Compounds with hiv maturation inhibitory activity
PL237998B1 (pl) 2018-05-28 2021-06-28 Narodowy Inst Lekow Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie
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CA2826113C (en) * 2011-01-31 2018-09-04 Bristol-Myers Squibb Company C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity

Also Published As

Publication number Publication date
JP6000283B2 (ja) 2016-09-28
CY1116989T1 (el) 2017-04-05
PT2670764E (pt) 2015-11-20
HUE026371T2 (en) 2016-05-30
CN103339141B (zh) 2016-08-24
ES2552512T3 (es) 2015-11-30
PL2670764T3 (pl) 2016-02-29
RS54352B1 (en) 2016-02-29
US8748415B2 (en) 2014-06-10
EA201391098A1 (ru) 2013-12-30
EP2670764A1 (en) 2013-12-11
WO2012106188A1 (en) 2012-08-09
BR112014010105A2 (pt) 2017-06-13
JP2014507422A (ja) 2014-03-27
HRP20151212T1 (hr) 2015-12-04
DK2670764T3 (en) 2015-12-07
CN103339141A (zh) 2013-10-02
SMT201500303B (it) 2016-01-08
EA023578B1 (ru) 2016-06-30
CA2826257A1 (en) 2012-08-09
EP2670764B1 (en) 2015-09-02
US20130029954A1 (en) 2013-01-31
SI2670764T1 (sl) 2016-03-31

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