MX2012013628A - Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih). - Google Patents
Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih).Info
- Publication number
- MX2012013628A MX2012013628A MX2012013628A MX2012013628A MX2012013628A MX 2012013628 A MX2012013628 A MX 2012013628A MX 2012013628 A MX2012013628 A MX 2012013628A MX 2012013628 A MX2012013628 A MX 2012013628A MX 2012013628 A MX2012013628 A MX 2012013628A
- Authority
- MX
- Mexico
- Prior art keywords
- modified
- acid derivatives
- betulinic acid
- amides
- maturation inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invención describe compuestos que tienen propiedades farmacológicas y que afectan el aspecto biológico, sus composiciones farmacéuticas y métodos de uso. En particular, derivados de ácido betulínico C-3 y C-28 modificados que poseen una actividad antiviral única como inhibidores de la maduración del VIH. Estos compuestos son útiles para el tratamiento del VIH y del SIDA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35133210P | 2010-06-04 | 2010-06-04 | |
PCT/US2011/038884 WO2011153319A1 (en) | 2010-06-04 | 2011-06-02 | C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012013628A true MX2012013628A (es) | 2012-12-17 |
Family
ID=44627254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013628A MX2012013628A (es) | 2010-06-04 | 2011-06-02 | Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih). |
Country Status (20)
Country | Link |
---|---|
US (1) | US8802661B2 (es) |
EP (1) | EP2576586B1 (es) |
JP (1) | JP5755731B2 (es) |
CN (1) | CN102985438B (es) |
AR (1) | AR081638A1 (es) |
BR (1) | BR112012030810A2 (es) |
CA (1) | CA2801491C (es) |
DK (1) | DK2576586T3 (es) |
EA (1) | EA026140B1 (es) |
ES (1) | ES2548905T3 (es) |
HR (1) | HRP20150977T1 (es) |
HU (1) | HUE026662T2 (es) |
MX (1) | MX2012013628A (es) |
PL (1) | PL2576586T3 (es) |
PT (1) | PT2576586E (es) |
RS (1) | RS54239B1 (es) |
SI (1) | SI2576586T1 (es) |
SM (1) | SMT201500272B (es) |
TW (1) | TW201201792A (es) |
WO (1) | WO2011153319A1 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2826113C (en) * | 2011-01-31 | 2018-09-04 | Bristol-Myers Squibb Company | C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity |
MX2013008359A (es) * | 2011-01-31 | 2013-08-27 | Bristol Myers Squibb Co | Aminas de c-28 de derivados de acido betulinico modificado de c-3 como inhibidores de la maduracion del virus de inmunodeficiencia humana. |
US8754069B2 (en) | 2011-09-21 | 2014-06-17 | Bristol-Myers Squibb Company | Betulinic acid derivatives with antiviral activity |
US8906889B2 (en) * | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
US8889854B2 (en) * | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
WO2014105926A1 (en) | 2012-12-31 | 2014-07-03 | Hetero Research Foundation | Novel betulinic acid proline derivatives as hiv inhibitors |
KR20150115881A (ko) * | 2013-02-06 | 2015-10-14 | 브리스톨-마이어스 스큅 컴퍼니 | Hiv 성숙 억제 활성을 갖는 c-19 변형된 트리테르페노이드 |
US9249180B2 (en) * | 2013-02-25 | 2016-02-02 | Bristol-Myers Squibb Company | C-3 alkyl and alkenyl modified betulinic acid derivatives |
WO2015157483A1 (en) | 2014-04-11 | 2015-10-15 | Bristol-Myers Squibb Company | Triterpenoids with hiv maturation inhibitory activity, substituted in position 3 by a non-aromatic ring carrying a haloalkyl substituent |
WO2015195776A1 (en) | 2014-06-19 | 2015-12-23 | Bristol-Myers Squibb Company | Betulinic acid derivatives with hiv maturation inhibitory activity |
US20170129916A1 (en) | 2014-06-26 | 2017-05-11 | Hetero Research Foundation | Novel betulinic proline imidazole derivatives as hiv inhibitors |
WO2015198263A2 (en) * | 2014-06-26 | 2015-12-30 | Hetero Research Foundation | Novel betulinic proline substituted derivatives as hiv inhibitors |
CA2967679A1 (en) * | 2014-11-14 | 2016-05-19 | VIIV Healthcare UK (No.5) Limited | Oxolupene derivatives |
JP2017533934A (ja) | 2014-11-14 | 2017-11-16 | ヴィーブ ヘルスケア ユーケー(ナンバー5)リミテッド | C17アリール置換ベツリン酸類似体 |
MA40886B1 (fr) | 2015-02-09 | 2020-03-31 | Hetero Research Foundation | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih |
US10370405B2 (en) | 2015-03-16 | 2019-08-06 | Hetero Labs Limited | C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors |
KR20180028534A (ko) | 2015-07-28 | 2018-03-16 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | Hiv 감염을 예방하거나 치료하기 위한 베투인 유도체 |
EP3328875A1 (en) | 2015-07-28 | 2018-06-06 | Glaxosmithkline Intellectual Property (No. 2) Limited | Betuin derivatives for preventing or treating hiv infections |
WO2017051355A1 (en) | 2015-09-24 | 2017-03-30 | Glaxosmithkline Intellectual Property (No.2) Limited | Compounds with hiv maturation inhibitory activity |
US20190023733A1 (en) | 2016-01-20 | 2019-01-24 | Glaxosmithkline Intellectual Property (No.2) Limited | Amine derivatives of lupanes with hiv maturation inhibitory activity |
AR107512A1 (es) | 2016-02-04 | 2018-05-09 | VIIV HEALTHCARE UK Nº 5 LTD | Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1 |
WO2018002849A1 (en) * | 2016-06-30 | 2018-01-04 | VIIV Healthcare UK (No.5) Limited | Triterpenoid inhibitors of human immunodeficiency virus replication |
JP7436385B2 (ja) | 2018-04-24 | 2024-02-21 | ヴィーブ ヘルスケア ユーケー(ナンバー5)リミテッド | Hiv成熟阻害活性を有する化合物 |
PL237998B1 (pl) | 2018-05-28 | 2021-06-28 | Narodowy Inst Lekow | Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie |
US10343997B1 (en) | 2018-12-04 | 2019-07-09 | King Saud University | Ursolic acid derivatives |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5413999A (en) | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
US5962527A (en) | 1995-03-21 | 1999-10-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for treating cancers |
US5869535A (en) | 1995-03-21 | 1999-02-09 | The Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma |
US5679828A (en) * | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
PT1068219E (pt) * | 1998-03-02 | 2007-03-30 | Univ North Carolina | Derivados acilados de betulina e de di-hidrobetulina, sua preparação e sua utilização |
US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
US7365221B2 (en) | 2002-09-26 | 2008-04-29 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
CA2499038A1 (en) * | 2002-09-26 | 2004-04-08 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
US20050014730A1 (en) | 2003-04-02 | 2005-01-20 | Carlson Robert M. | Anti-fungal formulation of triterpene and essential oil |
US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
WO2005090380A1 (en) | 2004-03-17 | 2005-09-29 | Panacos Pharmaceuticals, Inc. | Pharmaceuticals salts of 3-o-(3',3'-dimethylsuccinyl) betulinic acid |
WO2005112929A2 (en) * | 2004-05-20 | 2005-12-01 | Cornell Research Foundation, Inc. | Anti-hiv-1 activity of betulinol derivatives |
US7282521B2 (en) * | 2004-05-24 | 2007-10-16 | University Of North Carolina At Chapel Hill | Anti-retroviral moronic acid derivatives |
TW200628161A (en) * | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
JP2009527563A (ja) * | 2006-02-21 | 2009-07-30 | アキリオン ファーマシューティカルズ,インコーポレーテッド | ウイルス感染症を治療するのに有用な置換タラキサスタン |
WO2008097341A2 (en) * | 2006-07-26 | 2008-08-14 | Myriad Genetics, Inc. | Antiviral compounds and use thereof |
WO2008127364A2 (en) * | 2006-10-13 | 2008-10-23 | Myriad Genetics, Inc. | Antiviral compounds and use thereof |
US20110144069A1 (en) | 2006-10-16 | 2011-06-16 | Myriad Genetics, Incorporated | Compounds for treating viral infections |
WO2009020732A1 (en) * | 2007-08-03 | 2009-02-12 | Advanced Life Sciences, Inc. | Lupane-type triterpenoids modified at 30-position and analogues thereof |
WO2009042166A1 (en) | 2007-09-25 | 2009-04-02 | Panacos Pharmaceuticals, Inc. | Liquid bevirimat dosage forms for oral administration |
EP2257567A1 (en) | 2008-02-14 | 2010-12-08 | Virochem Pharma Inc. | Novel 17 beta lupane derivatives |
WO2009114083A2 (en) | 2008-03-03 | 2009-09-17 | Panacos Pharmaceuticals, Inc. | Determinants of antiviral response |
WO2009129548A1 (en) * | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives |
CN102883608A (zh) * | 2010-02-11 | 2013-01-16 | 葛兰素史密丝克莱恩有限责任公司 | 白桦脂醇衍生物 |
-
2011
- 2011-06-02 DK DK11726564.5T patent/DK2576586T3/en active
- 2011-06-02 HU HUE11726564A patent/HUE026662T2/en unknown
- 2011-06-02 WO PCT/US2011/038884 patent/WO2011153319A1/en active Application Filing
- 2011-06-02 EP EP11726564.5A patent/EP2576586B1/en active Active
- 2011-06-02 CN CN201180035812.4A patent/CN102985438B/zh not_active Expired - Fee Related
- 2011-06-02 PT PT117265645T patent/PT2576586E/pt unknown
- 2011-06-02 EA EA201270800A patent/EA026140B1/ru not_active IP Right Cessation
- 2011-06-02 ES ES11726564.5T patent/ES2548905T3/es active Active
- 2011-06-02 PL PL11726564T patent/PL2576586T3/pl unknown
- 2011-06-02 US US13/151,722 patent/US8802661B2/en not_active Expired - Fee Related
- 2011-06-02 RS RS20150587A patent/RS54239B1/en unknown
- 2011-06-02 JP JP2013513340A patent/JP5755731B2/ja not_active Expired - Fee Related
- 2011-06-02 MX MX2012013628A patent/MX2012013628A/es active IP Right Grant
- 2011-06-02 BR BR112012030810A patent/BR112012030810A2/pt not_active IP Right Cessation
- 2011-06-02 CA CA2801491A patent/CA2801491C/en not_active Expired - Fee Related
- 2011-06-02 SI SI201130604T patent/SI2576586T1/sl unknown
- 2011-06-03 AR ARP110101945A patent/AR081638A1/es not_active Application Discontinuation
- 2011-06-03 TW TW100119710A patent/TW201201792A/zh unknown
-
2015
- 2015-09-16 HR HRP20150977TT patent/HRP20150977T1/hr unknown
- 2015-10-30 SM SM201500272T patent/SMT201500272B/it unknown
Also Published As
Publication number | Publication date |
---|---|
EA201270800A1 (ru) | 2013-04-30 |
EA026140B1 (ru) | 2017-03-31 |
JP2013527243A (ja) | 2013-06-27 |
US20120142653A1 (en) | 2012-06-07 |
PL2576586T3 (pl) | 2016-01-29 |
PT2576586E (pt) | 2015-10-23 |
WO2011153319A1 (en) | 2011-12-08 |
SMT201500272B (it) | 2016-01-08 |
HUE026662T2 (en) | 2016-06-28 |
SI2576586T1 (sl) | 2015-11-30 |
CA2801491A1 (en) | 2011-12-08 |
JP5755731B2 (ja) | 2015-07-29 |
CN102985438A (zh) | 2013-03-20 |
BR112012030810A2 (pt) | 2019-09-24 |
HRP20150977T1 (hr) | 2015-10-09 |
DK2576586T3 (en) | 2015-11-23 |
EP2576586B1 (en) | 2015-08-12 |
RS54239B1 (en) | 2015-12-31 |
CA2801491C (en) | 2018-01-23 |
ES2548905T3 (es) | 2015-10-21 |
US8802661B2 (en) | 2014-08-12 |
EP2576586A1 (en) | 2013-04-10 |
AR081638A1 (es) | 2012-10-10 |
TW201201792A (en) | 2012-01-16 |
CN102985438B (zh) | 2016-05-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2012013628A (es) | Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih). | |
MX2012013703A (es) | Derivados de acido c-3-betulinico modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih). | |
TN2013000321A1 (en) | C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity | |
MX2013008359A (es) | Aminas de c-28 de derivados de acido betulinico modificado de c-3 como inhibidores de la maduracion del virus de inmunodeficiencia humana. | |
MX2014013089A (es) | Aminas biciclicas c-17 de triterpenoides con actividad inhibidora de la maduracion del virus de inmunodeficiencia humana (vih). | |
MX2015010354A (es) | Derivados de acido betulinico modificados con aquilo c-3 y alquenilo utiles en el tratamiento de virus de inmunodeficiencia humana (vih). | |
PH12014501816A1 (en) | C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity | |
GEP20186838B (en) | 5-phenoxy-3h-pyrimidin-4-one derivatives and their usage as hiv reverse transcriptase inhibitors | |
MX344238B (es) | Compuestos de tetrazol y métodos para preparar y usar los mismos. | |
TN2012000428A1 (en) | Bisaryl-bonded aryltriazolones and use thereof | |
AU2012253757A8 (en) | Partially saturated tricyclic compounds and methods of making and using same | |
TN2012000465A1 (en) | Derivatives of 1-amino-2-cyclopropylethylboronic acid | |
MX2012000565A (es) | Derivados de triterpeno tipo lupeol como antivirales. | |
IN2012DN00971A (es) | ||
MX2015010003A (es) | Triterpenoides c-19 modificados, con actividad inhibidora de la maduracion del virus de inmunodeficiencia humana (vih). | |
PH12015500062A1 (en) | 3-substituted estra-1,3,5(10),16-tetraene derivatives, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments | |
MX2014002936A (es) | Nuevos derivados de acido betulinico con actividad antiviral. | |
JO3122B1 (ar) | مشتقات إسترا-5،3،1(10)، 16- تترايين-3- كربوكساميد، عمليات لتحضيرها، مستحضرات دوائية تشتمل عليها واستخدامها لتحضير أدوية | |
PH12017550077A1 (en) | C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors | |
JOP20170029B1 (ar) | C-3 وc-17 تراي تربينويد معدلة كمثبطات لـhiv-1 | |
PH12018501640A1 (en) | C-3 and c-17 modified triterpenoids as hiv-1 inhibitors | |
MX2013008536A (es) | Triterpenoides c-17 y c-3 modificados con actividad inhibidora de la maduracion del virus de inmunodeficiencia humana. | |
CY1116905T1 (el) | C-28 αμιδια τροποποιημενων c-3 παραγωγων βετουλινικου οξεος ως αναστολεις hiv ωριμανσης | |
JOP20120346B1 (ar) | مركبات لعلاج ومنع الإلتصاق، وتركيبات صيدلية متعلقة بالمركب وطرق لمنع وعلاج الإلتصاقات | |
NZ625516A (en) | Derivatives of betulin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |