MX2012013628A - Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih). - Google Patents

Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih).

Info

Publication number
MX2012013628A
MX2012013628A MX2012013628A MX2012013628A MX2012013628A MX 2012013628 A MX2012013628 A MX 2012013628A MX 2012013628 A MX2012013628 A MX 2012013628A MX 2012013628 A MX2012013628 A MX 2012013628A MX 2012013628 A MX2012013628 A MX 2012013628A
Authority
MX
Mexico
Prior art keywords
modified
acid derivatives
betulinic acid
amides
maturation inhibitors
Prior art date
Application number
MX2012013628A
Other languages
English (en)
Inventor
Sing-Yuen Sit
Alicia Regueiro-Ren
Ny Sin
Nicholas A Meanwell
Jacob Swidorski
Zheng Liu
Yan Chen
Jie Chen
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2012013628A publication Critical patent/MX2012013628A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J63/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008Expansion of ring D by one atom, e.g. D homo steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención describe compuestos que tienen propiedades farmacológicas y que afectan el aspecto biológico, sus composiciones farmacéuticas y métodos de uso. En particular, derivados de ácido betulínico C-3 y C-28 modificados que poseen una actividad antiviral única como inhibidores de la maduración del VIH. Estos compuestos son útiles para el tratamiento del VIH y del SIDA.
MX2012013628A 2010-06-04 2011-06-02 Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih). MX2012013628A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35133210P 2010-06-04 2010-06-04
PCT/US2011/038884 WO2011153319A1 (en) 2010-06-04 2011-06-02 C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors

Publications (1)

Publication Number Publication Date
MX2012013628A true MX2012013628A (es) 2012-12-17

Family

ID=44627254

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012013628A MX2012013628A (es) 2010-06-04 2011-06-02 Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih).

Country Status (20)

Country Link
US (1) US8802661B2 (es)
EP (1) EP2576586B1 (es)
JP (1) JP5755731B2 (es)
CN (1) CN102985438B (es)
AR (1) AR081638A1 (es)
BR (1) BR112012030810A2 (es)
CA (1) CA2801491C (es)
DK (1) DK2576586T3 (es)
EA (1) EA026140B1 (es)
ES (1) ES2548905T3 (es)
HR (1) HRP20150977T1 (es)
HU (1) HUE026662T2 (es)
MX (1) MX2012013628A (es)
PL (1) PL2576586T3 (es)
PT (1) PT2576586E (es)
RS (1) RS54239B1 (es)
SI (1) SI2576586T1 (es)
SM (1) SMT201500272B (es)
TW (1) TW201201792A (es)
WO (1) WO2011153319A1 (es)

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RS54352B1 (en) * 2011-01-31 2016-02-29 Bristol-Myers Squibb Company C-28 AMINES OF C-3 MODIFIED BETULINIC ACID DERIVATIVES AS HIV INVESTIGATION INHIBITORS
CA2826113C (en) * 2011-01-31 2018-09-04 Bristol-Myers Squibb Company C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity
KR20140069167A (ko) 2011-09-21 2014-06-09 브리스톨-마이어스 스큅 컴퍼니 항바이러스 활성을 갖는 신규 베툴린산 유도체
US8906889B2 (en) 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US8889854B2 (en) * 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
EP2953960A1 (en) * 2013-02-06 2015-12-16 Bristol-Myers Squibb Company C-19 modified triterpenoids with hiv maturation inhibitory activity
CN105102468A (zh) * 2013-02-25 2015-11-25 百时美施贵宝公司 用于治疗hiv的c-3烷基和烯基修饰的桦木酸衍生物
CA2944778C (en) 2014-04-11 2022-06-14 ViiV Healthcare UK (No.4) Limited Triterpenoids with hiv maturation inhibitory activity
WO2015195776A1 (en) 2014-06-19 2015-12-23 Bristol-Myers Squibb Company Betulinic acid derivatives with hiv maturation inhibitory activity
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
WO2015198263A2 (en) * 2014-06-26 2015-12-30 Hetero Research Foundation Novel betulinic proline substituted derivatives as hiv inhibitors
US9969767B2 (en) 2014-11-14 2018-05-15 VIIV Healthcare UK (No.5) Limited Oxolupene derivatives
KR20170092581A (ko) 2014-11-14 2017-08-11 비브 헬스케어 유케이 (넘버5) 리미티드 C17-아릴 치환된 베툴린산 유사체
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
CN108026139A (zh) 2015-07-28 2018-05-11 葛兰素史克知识产权第二有限公司 用于预防或治疗hiv感染的白桦脂醇衍生物
KR20180028534A (ko) 2015-07-28 2018-03-16 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Hiv 감염을 예방하거나 치료하기 위한 베투인 유도체
KR20180054826A (ko) * 2015-09-24 2018-05-24 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Hiv 성숙 억제 활성을 갖는 화합물
EP3405474A1 (en) 2016-01-20 2018-11-28 Glaxosmithkline Intellectual Property (No. 2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
EP3478703A1 (en) * 2016-06-30 2019-05-08 ViiV Healthcare UK (No.5) Limited Triterpenoid inhibitors of human immunodeficiency virus replication
EP4321164A3 (en) 2018-04-24 2024-04-17 ViiV Healthcare UK (No.5) Limited Compounds with hiv maturation inhibitory activity
PL237998B1 (pl) 2018-05-28 2021-06-28 Narodowy Inst Lekow Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie
US10343997B1 (en) 2018-12-04 2019-07-09 King Saud University Ursolic acid derivatives

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Also Published As

Publication number Publication date
AR081638A1 (es) 2012-10-10
SMT201500272B (it) 2016-01-08
EP2576586A1 (en) 2013-04-10
PT2576586E (pt) 2015-10-23
DK2576586T3 (en) 2015-11-23
CN102985438B (zh) 2016-05-18
CN102985438A (zh) 2013-03-20
EA201270800A1 (ru) 2013-04-30
US20120142653A1 (en) 2012-06-07
JP5755731B2 (ja) 2015-07-29
TW201201792A (en) 2012-01-16
US8802661B2 (en) 2014-08-12
EA026140B1 (ru) 2017-03-31
SI2576586T1 (sl) 2015-11-30
JP2013527243A (ja) 2013-06-27
WO2011153319A1 (en) 2011-12-08
CA2801491C (en) 2018-01-23
PL2576586T3 (pl) 2016-01-29
RS54239B1 (en) 2015-12-31
ES2548905T3 (es) 2015-10-21
CA2801491A1 (en) 2011-12-08
HRP20150977T1 (hr) 2015-10-09
HUE026662T2 (en) 2016-06-28
BR112012030810A2 (pt) 2019-09-24
EP2576586B1 (en) 2015-08-12

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