MX2012013703A - Derivados de acido c-3-betulinico modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih). - Google Patents

Derivados de acido c-3-betulinico modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih).

Info

Publication number
MX2012013703A
MX2012013703A MX2012013703A MX2012013703A MX2012013703A MX 2012013703 A MX2012013703 A MX 2012013703A MX 2012013703 A MX2012013703 A MX 2012013703A MX 2012013703 A MX2012013703 A MX 2012013703A MX 2012013703 A MX2012013703 A MX 2012013703A
Authority
MX
Mexico
Prior art keywords
modified
betulinic acid
maturation inhibitors
acid derivatives
hiv maturation
Prior art date
Application number
MX2012013703A
Other languages
English (en)
Inventor
Sing-Yuen Sit
Alicia Regueiro-Ren
Nicholas A Meanwell
Jacob Swidorski
Zheng Liu
Jie Chen
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2012013703A publication Critical patent/MX2012013703A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se definen compuestos que tienen propiedades farmacológicas y bioafección, sus composiciones farmacéuticas y métodos de uso. En particular, ácido C3-betulínico modificado y otros derivados de productos naturales relacionados estructuralmente que poseen una actividad antiviral única se proporcionan como inhibidores de la maduración del VIH. Estos compuestos son útiles para el tratamiento del VIH y el SIDA.
MX2012013703A 2010-06-04 2011-06-02 Derivados de acido c-3-betulinico modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih). MX2012013703A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35133810P 2010-06-04 2010-06-04
PCT/US2011/038879 WO2011153315A1 (en) 2010-06-04 2011-06-02 Modified c-3 betulinic acid derivatives as hiv maturation inhibitors

Publications (1)

Publication Number Publication Date
MX2012013703A true MX2012013703A (es) 2012-12-17

Family

ID=44627236

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012013703A MX2012013703A (es) 2010-06-04 2011-06-02 Derivados de acido c-3-betulinico modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih).

Country Status (12)

Country Link
US (1) US8754068B2 (es)
EP (1) EP2576585B8 (es)
JP (1) JP5752789B2 (es)
CN (1) CN103038245B (es)
AR (1) AR081637A1 (es)
BR (1) BR112012030818A2 (es)
CA (1) CA2801487C (es)
EA (1) EA022393B1 (es)
ES (1) ES2612452T3 (es)
MX (1) MX2012013703A (es)
TW (1) TW201201793A (es)
WO (1) WO2011153315A1 (es)

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CA2826113C (en) * 2011-01-31 2018-09-04 Bristol-Myers Squibb Company C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity
CN104080454B (zh) 2011-06-06 2017-02-15 爱荷华大学研究基金会 用于抑制肌萎缩的方法
US8754069B2 (en) 2011-09-21 2014-06-17 Bristol-Myers Squibb Company Betulinic acid derivatives with antiviral activity
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US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
WO2014105926A1 (en) 2012-12-31 2014-07-03 Hetero Research Foundation Novel betulinic acid proline derivatives as hiv inhibitors
KR20150115881A (ko) * 2013-02-06 2015-10-14 브리스톨-마이어스 스큅 컴퍼니 Hiv 성숙 억제 활성을 갖는 c-19 변형된 트리테르페노이드
US9249180B2 (en) * 2013-02-25 2016-02-02 Bristol-Myers Squibb Company C-3 alkyl and alkenyl modified betulinic acid derivatives
WO2015157483A1 (en) 2014-04-11 2015-10-15 Bristol-Myers Squibb Company Triterpenoids with hiv maturation inhibitory activity, substituted in position 3 by a non-aromatic ring carrying a haloalkyl substituent
WO2015195776A1 (en) 2014-06-19 2015-12-23 Bristol-Myers Squibb Company Betulinic acid derivatives with hiv maturation inhibitory activity
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
CA2967679A1 (en) * 2014-11-14 2016-05-19 VIIV Healthcare UK (No.5) Limited Oxolupene derivatives
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JP2017533934A (ja) 2014-11-14 2017-11-16 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド Ｃ１７アリール置換ベツリン酸類似体
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
KR20180028534A (ko) 2015-07-28 2018-03-16 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Hiv 감염을 예방하거나 치료하기 위한 베투인 유도체
EP3328875A1 (en) 2015-07-28 2018-06-06 Glaxosmithkline Intellectual Property (No. 2) Limited Betuin derivatives for preventing or treating hiv infections
WO2017051355A1 (en) 2015-09-24 2017-03-30 Glaxosmithkline Intellectual Property (No.2) Limited Compounds with hiv maturation inhibitory activity
US20190023733A1 (en) 2016-01-20 2019-01-24 Glaxosmithkline Intellectual Property (No.2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
EP3478661A1 (en) * 2016-06-30 2019-05-08 ViiV Healthcare UK (No.5) Limited Aza-substituted inhibitors of human immunodeficiency virus replication
WO2018002849A1 (en) * 2016-06-30 2018-01-04 VIIV Healthcare UK (No.5) Limited Triterpenoid inhibitors of human immunodeficiency virus replication
WO2018002848A1 (en) * 2016-06-30 2018-01-04 VIIV Healthcare UK (No.5) Limited Azadecalin derivatives as inhibitors of human immunodeficiency virus replication
JP7436385B2 (ja) 2018-04-24 2024-02-21 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド Ｈｉｖ成熟阻害活性を有する化合物
PL237998B1 (pl) 2018-05-28 2021-06-28 Narodowy Inst Lekow Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie

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Also Published As

Publication number Publication date
CA2801487C (en) 2017-12-05
EP2576585B1 (en) 2016-10-12
US8754068B2 (en) 2014-06-17
EP2576585A1 (en) 2013-04-10
JP5752789B2 (ja) 2015-07-22
CA2801487A1 (en) 2011-12-08
TW201201793A (en) 2012-01-16
ES2612452T3 (es) 2017-05-17
CN103038245A (zh) 2013-04-10
EP2576585B8 (en) 2016-12-21
WO2011153315A1 (en) 2011-12-08
BR112012030818A2 (pt) 2019-09-24
EA201270780A1 (ru) 2013-04-30
US20120142707A1 (en) 2012-06-07
JP2013527242A (ja) 2013-06-27
CN103038245B (zh) 2015-03-25
AR081637A1 (es) 2012-10-10
EA022393B1 (ru) 2015-12-30

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