BR112012030818A2 - "derivados de ácido c-3 betulínico modificado como inibidores da maturação do hiv" - Google Patents

"derivados de ácido c-3 betulínico modificado como inibidores da maturação do hiv"

Info

Publication number
BR112012030818A2
BR112012030818A2 BR112012030818A BR112012030818A BR112012030818A2 BR 112012030818 A2 BR112012030818 A2 BR 112012030818A2 BR 112012030818 A BR112012030818 A BR 112012030818A BR 112012030818 A BR112012030818 A BR 112012030818A BR 112012030818 A2 BR112012030818 A2 BR 112012030818A2
Authority
BR
Brazil
Prior art keywords
inhibitors
modified
betulinic acid
acid derivatives
hiv maturation
Prior art date
Application number
BR112012030818A
Other languages
English (en)
Inventor
Regueiro-Ren Alicia
Swidorski Jacob
Liu Zheng
A. Meanwell Nicholas
Sit Sing-Yuen
Chen Jie
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of BR112012030818A2 publication Critical patent/BR112012030818A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Abstract

derivados de ácido c-3 betulínico modificado inibidores da maturação do hiv. compostos tendo propriedades medicamentosas e que podem afetar biologia, suas composições farmacêuticas e métodos de uso são apresentados. em particular, ácido c-3 betulínico modificado e outros derivados de produtos naturais estruturalmente relacionados que possuem atividade antiviral ímpar são fornecidos como inibidores da maturação do hiv. esses compostos são úteis para o tratamento de hiv e aids.
BR112012030818A 2010-06-04 2011-06-02 "derivados de ácido c-3 betulínico modificado como inibidores da maturação do hiv" BR112012030818A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35133810P 2010-06-04 2010-06-04
PCT/US2011/038879 WO2011153315A1 (en) 2010-06-04 2011-06-02 Modified c-3 betulinic acid derivatives as hiv maturation inhibitors

Publications (1)

Publication Number Publication Date
BR112012030818A2 true BR112012030818A2 (pt) 2019-09-24

Family

ID=44627236

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012030818A BR112012030818A2 (pt) 2010-06-04 2011-06-02 "derivados de ácido c-3 betulínico modificado como inibidores da maturação do hiv"

Country Status (12)

Country Link
US (1) US8754068B2 (pt)
EP (1) EP2576585B8 (pt)
JP (1) JP5752789B2 (pt)
CN (1) CN103038245B (pt)
AR (1) AR081637A1 (pt)
BR (1) BR112012030818A2 (pt)
CA (1) CA2801487C (pt)
EA (1) EA022393B1 (pt)
ES (1) ES2612452T3 (pt)
MX (1) MX2012013703A (pt)
TW (1) TW201201793A (pt)
WO (1) WO2011153315A1 (pt)

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BR112018001537A2 (pt) 2015-07-28 2018-09-18 Glaxosmithkline Ip No 2 Ltd composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para tratamento e para prevenção de uma infecção por hiv em um indivíduo, e, uso de um composto ou sal
KR20180054826A (ko) 2015-09-24 2018-05-24 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Hiv 성숙 억제 활성을 갖는 화합물
CN108699103A (zh) 2016-01-20 2018-10-23 葛兰素史克知识产权第二有限公司 具有hiv成熟抑制活性的羽扇烷类的胺衍生物
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
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Also Published As

Publication number Publication date
JP2013527242A (ja) 2013-06-27
EP2576585B1 (en) 2016-10-12
US20120142707A1 (en) 2012-06-07
ES2612452T3 (es) 2017-05-17
EP2576585A1 (en) 2013-04-10
EP2576585B8 (en) 2016-12-21
EA201270780A1 (ru) 2013-04-30
CN103038245B (zh) 2015-03-25
CA2801487C (en) 2017-12-05
US8754068B2 (en) 2014-06-17
MX2012013703A (es) 2012-12-17
JP5752789B2 (ja) 2015-07-22
CA2801487A1 (en) 2011-12-08
TW201201793A (en) 2012-01-16
CN103038245A (zh) 2013-04-10
WO2011153315A1 (en) 2011-12-08
EA022393B1 (ru) 2015-12-30
AR081637A1 (es) 2012-10-10

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.