EA201690372A1 - Азапиридоновые соединения и их применение - Google Patents

Азапиридоновые соединения и их применение

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Publication number
EA201690372A1
EA201690372A1 EA201690372A EA201690372A EA201690372A1 EA 201690372 A1 EA201690372 A1 EA 201690372A1 EA 201690372 A EA201690372 A EA 201690372A EA 201690372 A EA201690372 A EA 201690372A EA 201690372 A1 EA201690372 A1 EA 201690372A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
azapiridone
azapiridon
application
infection
Prior art date
Application number
EA201690372A
Other languages
English (en)
Other versions
EA037949B1 (ru
Inventor
Леонид Бейгельман
Дэвид Бернард Смит
Антица Димитрова Стойчева
Роберт Тань Хендрикс
Original Assignee
Алиос Биофарма, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Алиос Биофарма, Инк. filed Critical Алиос Биофарма, Инк.
Publication of EA201690372A1 publication Critical patent/EA201690372A1/ru
Publication of EA037949B1 publication Critical patent/EA037949B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Abstract

В изобретении предложены азапиридоновые соединения, фармацевтические композиции, содержащие одно или более азапиридоновых соединений, и способы их синтеза. Также в изобретении предложены способы облегчения и/или лечения заболевания и/или состояния, включая ортомиксовирусную инфекцию, посредством азапиридоновых соединений. Примеры ортомиксовирусной вирусной инфекции включают инфекцию гриппа.
EA201690372A 2013-09-12 2014-09-10 Азапиридоновые соединения и их применение EA037949B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361877151P 2013-09-12 2013-09-12
US201462011784P 2014-06-13 2014-06-13
US201462031673P 2014-07-31 2014-07-31
PCT/US2014/055012 WO2015038655A1 (en) 2013-09-12 2014-09-10 Aza-pyridone compounds and uses thereof

Publications (2)

Publication Number Publication Date
EA201690372A1 true EA201690372A1 (ru) 2016-08-31
EA037949B1 EA037949B1 (ru) 2021-06-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690372A EA037949B1 (ru) 2013-09-12 2014-09-10 Азапиридоновые соединения и их применение

Country Status (19)

Country Link
US (5) US9328119B2 (ru)
EP (2) EP3030566B1 (ru)
JP (1) JP6448647B2 (ru)
KR (2) KR102323515B1 (ru)
CN (1) CN105764904B (ru)
AU (2) AU2014318832B2 (ru)
BR (1) BR112016005270B1 (ru)
CA (1) CA2923075C (ru)
CL (1) CL2016000539A1 (ru)
EA (1) EA037949B1 (ru)
ES (1) ES2821394T3 (ru)
HK (1) HK1225715A1 (ru)
IL (2) IL244432B (ru)
MX (2) MX2016003199A (ru)
PE (1) PE20160661A1 (ru)
PH (1) PH12016500486A1 (ru)
TW (1) TWI652269B (ru)
UA (1) UA121199C2 (ru)
WO (1) WO2015038655A1 (ru)

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IL274355A (en) 2020-06-30
AU2019201403A1 (en) 2019-03-21
IL244432A0 (en) 2016-04-21
EP3030566A4 (en) 2017-03-22
ES2821394T8 (es) 2021-05-12
TWI652269B (zh) 2019-03-01
BR112016005270B1 (pt) 2022-11-01
US10251882B2 (en) 2019-04-09
KR102468319B1 (ko) 2022-11-16
KR20160052715A (ko) 2016-05-12
US20150072982A1 (en) 2015-03-12
JP2016530314A (ja) 2016-09-29
MX2020012132A (es) 2021-01-29
US20200030328A1 (en) 2020-01-30
UA121199C2 (uk) 2020-04-27
US10980805B2 (en) 2021-04-20
EP3778603A1 (en) 2021-02-17
US9328119B2 (en) 2016-05-03
US20190314373A1 (en) 2019-10-17
CA2923075C (en) 2022-07-26
BR112016005270A2 (pt) 2017-12-12
PH12016500486A1 (en) 2016-05-16
JP6448647B2 (ja) 2019-01-09
WO2015038655A1 (en) 2015-03-19
CN105764904B (zh) 2020-02-11
KR102323515B1 (ko) 2021-11-05
AU2014318832B2 (en) 2018-11-29
KR20210135359A (ko) 2021-11-12
ES2821394T3 (es) 2021-04-26
PE20160661A1 (es) 2016-08-05
CN105764904A (zh) 2016-07-13
EP3030566A1 (en) 2016-06-15
CA2923075A1 (en) 2015-03-19
US20160228438A1 (en) 2016-08-11
US10702523B2 (en) 2020-07-07
IL274355B (en) 2021-02-28
EA037949B1 (ru) 2021-06-10
IL244432B (en) 2020-05-31
EP3030566B1 (en) 2020-07-08
AU2019201403B2 (en) 2021-01-21
US20210186969A1 (en) 2021-06-24
CL2016000539A1 (es) 2016-09-02
AU2014318832A1 (en) 2016-04-28
HK1225715A1 (zh) 2017-09-15
NZ717591A (en) 2021-10-29
TW201542553A (zh) 2015-11-16
MX2016003199A (es) 2016-06-02

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