EA201792008A1 - Соединения азапиридона и способы их применения - Google Patents

Соединения азапиридона и способы их применения

Info

Publication number
EA201792008A1
EA201792008A1 EA201792008A EA201792008A EA201792008A1 EA 201792008 A1 EA201792008 A1 EA 201792008A1 EA 201792008 A EA201792008 A EA 201792008A EA 201792008 A EA201792008 A EA 201792008A EA 201792008 A1 EA201792008 A1 EA 201792008A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
methods
azapiridone
azapiridon
application
Prior art date
Application number
EA201792008A
Other languages
English (en)
Other versions
EA036776B1 (ru
Inventor
Роберт Тань Хендрикс
Леонид Бейгельман
Дэвид Бернард Смит
Антица Димитрова Стойчева
Original Assignee
Элиос Биофарма, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элиос Биофарма, Инк. filed Critical Элиос Биофарма, Инк.
Publication of EA201792008A1 publication Critical patent/EA201792008A1/ru
Publication of EA036776B1 publication Critical patent/EA036776B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Abstract

В данном документе раскрыты новые соединения азапиридона, фармацевтические композиции, которые содержат одно или несколько соединений азапиридона, и способы их синтеза. Также в данном документе раскрыты способы снижения интенсивности и/или лечения заболевания и/или патологического состояния, включая инфекцию, вызванную ортомиксовирусом, соединением азапиридона. Примеры вызываемой ортомиксовирусом вирусной инфекции включают инфекцию, вызываемую вирусом гриппа.
EA201792008A 2015-03-11 2016-03-09 Соединения азапиридона и способы их применения EA036776B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562131708P 2015-03-11 2015-03-11
PCT/US2016/021598 WO2016145103A1 (en) 2015-03-11 2016-03-09 Aza-pyridone compounds and uses thereof

Publications (2)

Publication Number Publication Date
EA201792008A1 true EA201792008A1 (ru) 2018-05-31
EA036776B1 EA036776B1 (ru) 2020-12-21

Family

ID=56879649

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201792008A EA036776B1 (ru) 2015-03-11 2016-03-09 Соединения азапиридона и способы их применения

Country Status (10)

Country Link
US (1) US10208045B2 (ru)
EP (1) EP3268368A4 (ru)
CN (1) CN107531717B (ru)
AU (1) AU2016229147C1 (ru)
CA (1) CA2979216A1 (ru)
EA (1) EA036776B1 (ru)
HK (1) HK1246780A1 (ru)
MX (1) MX2017011655A (ru)
TW (1) TWI772256B (ru)
WO (1) WO2016145103A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2894542C (en) 2012-12-21 2023-10-31 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2015038655A1 (en) 2013-09-12 2015-03-19 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
WO2015038660A1 (en) 2013-09-12 2015-03-19 Alios Biopharma, Inc. Pyridazinone compounds and uses thereof
US10208045B2 (en) 2015-03-11 2019-02-19 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
CN108699059B (zh) 2016-03-08 2021-06-18 诺华股份有限公司 可用于治疗正粘病毒感染的三环化合物
WO2017156407A1 (en) 2016-03-10 2017-09-14 Alios Biopharma, Inc. Method of preparing aza-pyridone compounds
WO2017223231A1 (en) 2016-06-21 2017-12-28 Alios Biopharma, Inc. (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza
JOP20170169A1 (ar) 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
US11629149B2 (en) * 2018-02-28 2023-04-18 Novartis Ag 10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza
ES2937837T3 (es) * 2018-09-10 2023-03-31 Cocrystal Pharma Inc Inhibidores de piridopirazina y piridotriazina de la replicación del virus de la gripe

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPM354694A0 (en) 1994-01-27 1994-02-17 Biota Scientific Management Pty Ltd Chemical compounds
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
CN100357284C (zh) 2003-09-11 2007-12-26 浙江海正药业股份有限公司 抗流感病毒化合物及其制备方法和用途
CA2562244A1 (en) 2004-04-07 2005-10-27 Takeda Pharmaceutical Company Limited Cyclic compounds
WO2006028963A2 (en) 2004-09-03 2006-03-16 Celgene Corporation Substituted heterocyclic compounds and uses thereof
AR057623A1 (es) 2005-11-28 2007-12-05 Omega Bio Pharma H K Ltd Materiales y metodos para el tratamiento de las infecciones virales
CN101340902B (zh) 2005-11-28 2011-01-26 奥加生物药业（香港）有限公司 用半胱胺化合物处理病毒感染的材料和方法
FR2909090B1 (fr) 2006-11-23 2009-01-09 Sanofi Aventis Sa Derives de 2,5-dihydro-3h-pyrazolo[4,3-c]pyridazin-3-one substitues,leur preparation et leur application en therapeutique.
CN101880280B (zh) 2006-12-22 2014-07-16 中国科学院上海有机化学研究所 双环嘧啶酮以及其应用
WO2009053799A1 (en) 2007-10-24 2009-04-30 Glenmark Pharmaceuticals, S.A. Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
ES2623794T3 (es) 2008-12-09 2017-07-12 Gilead Sciences, Inc. Intermedios para la preparación de moduladores de receptores tipo toll
JP5683489B2 (ja) 2009-01-12 2015-03-11 アレイ バイオファーマ、インコーポレイテッド ピペリジン含有化合物およびその用途
UY32417A (es) 2009-02-05 2010-08-31 Takeda Pharmaceutical Compuestos de piridazinona
EP2398324B1 (en) 2009-02-23 2014-09-03 Merck Sharp & Dohme Corp. PYRAZOLO [4,3-c]CINNOLIN-3-ONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
KR20110128947A (ko) 2009-03-20 2011-11-30 앨리오스 바이오파마 인크. 치환된 뉴클레오시드 및 뉴클레오티드 유사체
TW201038572A (en) 2009-03-25 2010-11-01 Gruenenthal Gmbh Substituted spiro-amide compounds
US8835461B2 (en) 2009-03-26 2014-09-16 Shionogi & Co., Ltd. Substituted 3-hydroxy-4-pyridone derivative
TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
WO2010138419A2 (en) 2009-05-23 2010-12-02 Obio Pharmaceutical (H.K.) Ltd. Materials and methods for treating viral infections
US8927710B2 (en) 2009-06-15 2015-01-06 Shionogi & Co., Ltd. Substituted polycyclic carbamoylpyridone derivative
WO2011084371A1 (en) 2009-12-21 2011-07-14 Merck Sharp & Dohme Corp. Aminobenzoquinazolinone m1 receptor positive allosteric modulators
EP2552915B1 (en) 2010-04-01 2017-07-19 Critical Outcome Technologies Inc. Compounds for the treatment of hiv
US20130116231A1 (en) 2010-07-12 2013-05-09 Merck Sharp & Dohme Corp. Tyrosine kinase inhibitors
NZ607996A (en) 2010-09-22 2014-07-25 Alios Biopharma Inc Substituted nucleotide analogs
EP2619215B1 (en) 2010-09-22 2018-09-05 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
WO2012040126A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Substituted nucleotide analogs
SI2620436T1 (en) * 2010-09-24 2018-08-31 Shionogi & Co., Ltd. A prodrug substituted polycyclic carbamoyl pyridone derivative
WO2012088155A1 (en) 2010-12-22 2012-06-28 Alios Biopharma, Inc. Cyclic nucleotide analogs
US20140227321A1 (en) 2011-09-30 2014-08-14 Kineta, Inc. Anti-viral compounds
EP2794630A4 (en) 2011-12-22 2015-04-01 Alios Biopharma Inc SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE
BR112014014740B1 (pt) 2011-12-22 2021-08-24 Alios Biopharma, Inc Compostos de nucleosídeos, nucleotídeos e análogos destes, seu uso e composição farmacêutica
EP2828278A4 (en) 2012-03-21 2015-12-09 Alios Biopharma Inc PROCESSES FOR PREPARING SUBSTITUTED NUCLEOTIDE ANALOGS
WO2013142124A1 (en) 2012-03-21 2013-09-26 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
CN104203253A (zh) 2012-03-21 2014-12-10 艾丽奥斯生物制药有限公司 取代的核苷、核苷酸及其类似物
WO2013142159A1 (en) 2012-03-21 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
NZ630805A (en) 2012-03-22 2016-01-29 Alios Biopharma Inc Pharmaceutical combinations comprising a thionucleotide analog
CA2894542C (en) 2012-12-21 2023-10-31 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EP2935305A4 (en) 2012-12-21 2016-08-03 Alios Biopharma Inc SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGUE THEREOF
WO2014108406A1 (en) 2013-01-08 2014-07-17 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
US20150065439A1 (en) 2013-02-28 2015-03-05 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions
US20140309413A1 (en) 2013-03-11 2014-10-16 Vertex Pharmaceuticals Incorporated Methods of stereoselective synthesis of substituted nucleoside analogs
WO2014165704A1 (en) 2013-04-05 2014-10-09 Vertex Pharmaceuticals, Inc. Hepatitis c viral infection treatment using a combination of compounds
NZ714415A (en) 2013-06-26 2017-09-29 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
TW201542578A (zh) 2013-06-26 2015-11-16 Alios Biopharma Inc 經取代之核苷、核苷酸及其類似物
WO2015038655A1 (en) 2013-09-12 2015-03-19 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
WO2015038660A1 (en) 2013-09-12 2015-03-19 Alios Biopharma, Inc. Pyridazinone compounds and uses thereof
TW201524990A (zh) 2013-10-11 2015-07-01 Alios Biopharma Inc 經取代之核苷、核苷酸及其類似物
AU2015280234B2 (en) 2014-06-24 2021-04-01 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
NZ727392A (en) 2014-06-24 2018-04-27 Alios Biopharma Inc Methods of preparing substituted nucleotide analogs
CN106573011A (zh) 2014-06-24 2017-04-19 艾丽奥斯生物制药有限公司 取代的核苷、核苷酸和其类似物
EP3171878A4 (en) 2014-07-22 2018-03-14 Alios Biopharma, Inc. Methods for treating paramyxoviruses
SG11201700851WA (en) 2014-08-05 2017-03-30 Alios Biopharma Inc Combination therapy for treating a paramyxovirus
KR20170073649A (ko) 2014-10-28 2017-06-28 앨리오스 바이오파마 인크. 치환된 뉴클레오시드 유사체의 제조 방법
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
MA41441A (fr) 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
US10208045B2 (en) 2015-03-11 2019-02-19 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
WO2017156407A1 (en) 2016-03-10 2017-09-14 Alios Biopharma, Inc. Method of preparing aza-pyridone compounds
WO2017223231A1 (en) 2016-06-21 2017-12-28 Alios Biopharma, Inc. (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza

Also Published As

Publication number Publication date
US10208045B2 (en) 2019-02-19
TW201639850A (zh) 2016-11-16
CN107531717B (zh) 2021-07-27
EP3268368A4 (en) 2018-11-14
TWI772256B (zh) 2022-08-01
MX2017011655A (es) 2018-04-30
US20160264581A1 (en) 2016-09-15
AU2016229147C1 (en) 2021-03-25
CN107531717A (zh) 2018-01-02
EA036776B1 (ru) 2020-12-21
EP3268368A1 (en) 2018-01-17
AU2016229147A1 (en) 2017-09-28
HK1246780A1 (zh) 2018-09-14
CA2979216A1 (en) 2016-09-15
WO2016145103A1 (en) 2016-09-15
AU2016229147B2 (en) 2020-10-22

Similar Documents

Publication Publication Date Title
EA201792008A1 (ru) Соединения азапиридона и способы их применения
EA201690372A1 (ru) Азапиридоновые соединения и их применение
EA201791886A1 (ru) Антивирусные соединения
EA201790630A1 (ru) Способы получения рибозидов
MX2019002356A (es) Compuestos de biarilo utiles como inmunomoduladores.
EA201791420A1 (ru) Соединения триазолопиримидина и их применения
EA201890857A1 (ru) Соединения, применимые в качестве иммуномодуляторов
EA201691726A1 (ru) Новые 6-конденсированные гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b
EA201691261A1 (ru) Новые дигидрохинолизиноны для лечения и профилактики инфекции, вызванной вирусом гепатита b
EA201592126A1 (ru) 6-мостиковые гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b
EA201691857A1 (ru) Соединения, применимые в качестве иммуномодуляторов
EA201590384A1 (ru) 6-аминокислота-гетероарилдигидропиримидины для лечения и профилактики инфекции вируса гепатита в
EA201690224A1 (ru) Противовирусные соединения
EA201690371A1 (ru) Пиридазиноновые соединения и их применение
EA201790700A1 (ru) Моно- или дизамещенные индолы в качестве ингибиторов репликации вирусов денге
EA201790758A1 (ru) Производные моно- или дизамещенных индолов в качестве ингибиторов репликации вирусов денге
EA201591457A1 (ru) Терапевтические соединения
EA201892216A1 (ru) Замещенные производные индолина в качестве ингибиторов репликации вирусов денге
EA201892219A1 (ru) Замещенные производные индолина в качестве ингибиторов репликации вирусов денге
EA201792021A1 (ru) Ингибитор jak
EA201790571A1 (ru) Пирролопиримидины для применения при инфекции, вызванной вирусом гриппа
EA201791614A1 (ru) Производные индола в качестве ингибиторов репликации вирусов денге
EA202090720A1 (ru) ПРОИЗВОДНЫЕ GalNAc
EA201791896A1 (ru) Дезацетокситубулизин н и его аналоги
EA201691141A1 (ru) Соединения против ccr6

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM