EA201790266A1 - Индолы для применения при инфекции, вызванной вирусом гриппа - Google Patents

Индолы для применения при инфекции, вызванной вирусом гриппа

Info

Publication number
EA201790266A1
EA201790266A1 EA201790266A EA201790266A EA201790266A1 EA 201790266 A1 EA201790266 A1 EA 201790266A1 EA 201790266 A EA201790266 A EA 201790266A EA 201790266 A EA201790266 A EA 201790266A EA 201790266 A1 EA201790266 A1 EA 201790266A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indols
infections caused
flu virus
virus
flu
Prior art date
Application number
EA201790266A
Other languages
English (en)
Inventor
Тим Хьюго Мария Йонкерс
Пьер Жан-Мари Бернар Рабуассон
Жером Эмиль Жорж Гийемон
Дэвид Крейг Мак Гоуен
Вернер Констант Йохан Эмбрехтс
Людвиг Поль Коиманс
Антуан Бенжамен Мишо
Original Assignee
Янссен Сайенсиз Айрлэнд Юси
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Сайенсиз Айрлэнд Юси filed Critical Янссен Сайенсиз Айрлэнд Юси
Publication of EA201790266A1 publication Critical patent/EA201790266A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

Настоящее изобретение относится к соединениям, характеризующимся структурой формулы (I), которые могут быть использованы для лечения инфекций, вызванных вирусом гриппа, или их предотвращения.
EA201790266A 2014-08-08 2015-08-07 Индолы для применения при инфекции, вызванной вирусом гриппа EA201790266A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14180331 2014-08-08
PCT/EP2015/068257 WO2016020526A1 (en) 2014-08-08 2015-08-07 Indoles for use in influenza virus infection

Publications (1)

Publication Number Publication Date
EA201790266A1 true EA201790266A1 (ru) 2017-06-30

Family

ID=51298610

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790266A EA201790266A1 (ru) 2014-08-08 2015-08-07 Индолы для применения при инфекции, вызванной вирусом гриппа

Country Status (18)

Country Link
US (1) US10597390B2 (ru)
EP (1) EP3177609A1 (ru)
JP (1) JP6577570B2 (ru)
KR (1) KR102488479B1 (ru)
CN (1) CN106573920B (ru)
AU (1) AU2015298876B2 (ru)
BR (1) BR112017002370B1 (ru)
CA (1) CA2954751C (ru)
CL (1) CL2017000309A1 (ru)
EA (1) EA201790266A1 (ru)
IL (1) IL250408B (ru)
MA (1) MA40547A (ru)
MX (1) MX2017001752A (ru)
PH (1) PH12017500207A1 (ru)
SG (1) SG11201700956VA (ru)
UA (1) UA124609C2 (ru)
WO (1) WO2016020526A1 (ru)
ZA (1) ZA201700952B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS55341B1 (sr) 2009-06-17 2017-03-31 Vertex Pharma Inhibitori replikacije virusa gripa
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
EA201790266A1 (ru) 2014-08-08 2017-06-30 Янссен Сайенсиз Айрлэнд Юси Индолы для применения при инфекции, вызванной вирусом гриппа
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
US10717732B2 (en) 2015-12-09 2020-07-21 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
DK3400225T3 (da) * 2016-01-07 2022-01-03 Janssen Sciences Ireland Unlimited Co Pentansyrederivater substitueret med pyrrolo-[2,3-b]pyrimidinpyridiner til behandling af influenzavirusinfektioner
WO2017133670A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza
CN107759571B (zh) * 2016-08-16 2021-03-02 广东东阳光药业有限公司 流感病毒复制抑制剂及其使用方法和用途
US10647693B2 (en) 2016-08-30 2020-05-12 North & South Brother Pharmacy Investment Company Limited Inhibitors of influenza virus replication, application methods and uses thereof
EP3502112A4 (en) * 2016-09-05 2019-06-26 Guangdong Raynovent Biotech Co., Ltd. ANTI-INFLUENZA VIRUS-pyrimidine
CN108218873B (zh) 2016-12-15 2020-07-07 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途
JP7299837B2 (ja) * 2016-12-23 2023-06-28 アクイナ ファーマシューティカルズ， インコーポレイテッド 化合物、組成物、および使用方法
WO2018127096A1 (en) 2017-01-05 2018-07-12 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
US10927118B2 (en) 2017-03-02 2021-02-23 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
CN108727369B (zh) * 2017-04-25 2023-06-09 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途
RU2769050C1 (ru) * 2018-03-05 2022-03-28 Гуандун Рэйновент Байотек Ко., Лтд. Кристаллическая форма и солевая форма соединения пиридоимидазола и соответствующий способ получения
EP3992192A4 (en) * 2019-07-22 2022-08-17 Guangdong Raynovent Biotech Co., Ltd. DOMINANT SALT FORMS OF PYRIMIDINE DERIVATIVES AND CRYSTAL FORMS THEREOF
CN113045475A (zh) * 2019-12-27 2021-06-29 上海泓博智源医药股份有限公司 一种5-溴-7-甲基吲哚的制备方法
TW202216720A (zh) 2020-07-20 2022-05-01 美商尼道生物科學公司 作為雄激素受體調節劑的吲哚化合物

Family Cites Families (14)

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MXPA06011327A (es) 2004-03-30 2006-12-15 Vertex Pharma Azaindoles utiles como inhibidores de jak y otras proteinas cinasas.
CA2636189A1 (en) 2006-01-17 2007-07-26 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of janus kinases
RS55341B1 (sr) * 2009-06-17 2017-03-31 Vertex Pharma Inhibitori replikacije virusa gripa
WO2012032065A1 (en) * 2010-09-08 2012-03-15 Glaxo Group Limited Indazole derivatives for use in the treatment of influenza virus infection
CN103562205A (zh) * 2010-12-16 2014-02-05 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
RU2013132681A (ru) 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
BR112014004569A2 (pt) 2011-09-01 2017-06-13 F. Hoffmann-La Roche Ag composto da fórmula i, métodos para tratar condição inflamatória, artrite reumatoide, asma e distúrbio imune, composição farmacêutica e uso do composto
EP2858984A1 (en) * 2012-06-08 2015-04-15 Vertex Pharmaceuticals Inc. Inhibitors of influenza viruses replication
PL3068776T3 (pl) 2013-11-13 2019-10-31 Vertex Pharma Inhibitory replikacji wirusów grypy
EA201790266A1 (ru) 2014-08-08 2017-06-30 Янссен Сайенсиз Айрлэнд Юси Индолы для применения при инфекции, вызванной вирусом гриппа
UY36255A (es) 2014-08-08 2016-01-29 Bayer Cropscience Ag Compuestos sustituidos por halógeno novedosos
UY36249A (es) 2014-08-08 2016-01-29 Bayer Cropscience Ag Compuestos sustituidos con halógeno novedosos
CN104592038A (zh) 2015-01-12 2015-05-06 烟台万润精细化工股份有限公司 一种5,5-二甲基-1,3-环己二胺的制备方法

Also Published As

Publication number Publication date
SG11201700956VA (en) 2017-03-30
ZA201700952B (en) 2018-12-19
MX2017001752A (es) 2018-02-08
US20170226102A1 (en) 2017-08-10
CN106573920B (zh) 2020-11-10
JP6577570B2 (ja) 2019-09-18
BR112017002370A2 (pt) 2017-12-05
PH12017500207B1 (en) 2017-07-10
IL250408A0 (en) 2017-03-30
CL2017000309A1 (es) 2017-08-18
CA2954751C (en) 2023-01-17
BR112017002370B1 (pt) 2022-11-22
WO2016020526A1 (en) 2016-02-11
JP2017523225A (ja) 2017-08-17
PH12017500207A1 (en) 2017-07-10
EP3177609A1 (en) 2017-06-14
CN106573920A (zh) 2017-04-19
IL250408B (en) 2020-08-31
MA40547A (fr) 2017-06-14
AU2015298876A1 (en) 2017-02-02
AU2015298876B2 (en) 2020-02-13
UA124609C2 (uk) 2021-10-20
US10597390B2 (en) 2020-03-24
KR20170039275A (ko) 2017-04-10
CA2954751A1 (en) 2016-02-11
KR102488479B1 (ko) 2023-01-12

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