BR112017002370A2 - indóis para uso na infecção pelo vírus da gripe - Google Patents
indóis para uso na infecção pelo vírus da gripeInfo
- Publication number
- BR112017002370A2 BR112017002370A2 BR112017002370A BR112017002370A BR112017002370A2 BR 112017002370 A2 BR112017002370 A2 BR 112017002370A2 BR 112017002370 A BR112017002370 A BR 112017002370A BR 112017002370 A BR112017002370 A BR 112017002370A BR 112017002370 A2 BR112017002370 A2 BR 112017002370A2
- Authority
- BR
- Brazil
- Prior art keywords
- indoles
- influenza virus
- virus infection
- compounds
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
a invenção se refere a compostos tendo a estrutura de fórmula (i) que podem ser usados para o tratamento de ou contra infecções de gripe.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14180331 | 2014-08-08 | ||
EP14180331.2 | 2014-08-08 | ||
PCT/EP2015/068257 WO2016020526A1 (en) | 2014-08-08 | 2015-08-07 | Indoles for use in influenza virus infection |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017002370A2 true BR112017002370A2 (pt) | 2017-12-05 |
BR112017002370B1 BR112017002370B1 (pt) | 2022-11-22 |
Family
ID=51298610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017002370-9A BR112017002370B1 (pt) | 2014-08-08 | 2015-08-07 | Compostos indóis, composição farmacêutica que os compreende e seu uso na inibição da replicação do vírus da gripe |
Country Status (18)
Country | Link |
---|---|
US (1) | US10597390B2 (pt) |
EP (1) | EP3177609A1 (pt) |
JP (1) | JP6577570B2 (pt) |
KR (1) | KR102488479B1 (pt) |
CN (1) | CN106573920B (pt) |
AU (1) | AU2015298876B2 (pt) |
BR (1) | BR112017002370B1 (pt) |
CA (1) | CA2954751C (pt) |
CL (1) | CL2017000309A1 (pt) |
EA (1) | EA201790266A1 (pt) |
IL (1) | IL250408B (pt) |
MA (1) | MA40547A (pt) |
MX (1) | MX2017001752A (pt) |
PH (1) | PH12017500207B1 (pt) |
SG (1) | SG11201700956VA (pt) |
UA (1) | UA124609C2 (pt) |
WO (1) | WO2016020526A1 (pt) |
ZA (1) | ZA201700952B (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS55341B1 (sr) | 2009-06-17 | 2017-03-31 | Vertex Pharma | Inhibitori replikacije virusa gripa |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
AU2015298876B2 (en) | 2014-08-08 | 2020-02-13 | Janssen Sciences Ireland Uc | Indoles for use in influenza virus infection |
EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
KR20180088466A (ko) | 2015-12-09 | 2018-08-03 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 인플루엔자 바이러스 복제 저해제, 활용 방법 및 그 용도 |
LT3400225T (lt) * | 2016-01-07 | 2021-12-10 | Janssen Sciences Ireland Unlimited Company | Pirolo-[2-3,b]pirimidin-piridinais pakeistos pentanoinės rūgštys gripo virusinės infekcijos gydymui |
WO2017133670A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza |
CN107759571B (zh) * | 2016-08-16 | 2021-03-02 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其使用方法和用途 |
WO2018041091A1 (en) * | 2016-08-30 | 2018-03-08 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication, application methods and uses thereof |
EP3502112A1 (en) * | 2016-09-05 | 2019-06-26 | Guangdong Raynovent Biotech Co., Ltd. | Anti-influenza virus pyrimidine derivative |
CN108218873B (zh) | 2016-12-15 | 2020-07-07 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
EP3557998B1 (en) | 2016-12-23 | 2023-08-16 | Aquinnah Pharmaceuticals Inc. | Compouns, compositions and methods of use |
US11098042B2 (en) | 2017-01-05 | 2021-08-24 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
WO2018157830A1 (en) | 2017-03-02 | 2018-09-07 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
CN108727369B (zh) * | 2017-04-25 | 2023-06-09 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
US11535613B2 (en) | 2018-03-05 | 2022-12-27 | Guangdong Raynovent Biotech Co., Ltd. | Crystal form and salt form of pyridoimidazole compound and preparation method therefor |
US20220380363A1 (en) * | 2019-07-22 | 2022-12-01 | Guangdong Raynovent Biotech Co., Ltd. | Dominant salt forms of pyrimidine derivatives, and crystal forms thereof |
CN113045475A (zh) * | 2019-12-27 | 2021-06-29 | 上海泓博智源医药股份有限公司 | 一种5-溴-7-甲基吲哚的制备方法 |
KR20230079003A (ko) * | 2020-07-20 | 2023-06-05 | 니도 바이오사이언시스, 인코포레이티드 | 안드로겐 수용체 조절제로서의 인돌 화합물 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101676285A (zh) | 2004-03-30 | 2010-03-24 | 沃泰克斯药物股份有限公司 | 用作jak和其它蛋白激酶抑制剂的氮杂吲哚 |
EP2537849A3 (en) | 2006-01-17 | 2013-04-03 | Vertex Pharmaceuticals, Inc. | Azaindoles useful as inhibitors of janus kinases |
RS55341B1 (sr) * | 2009-06-17 | 2017-03-31 | Vertex Pharma | Inhibitori replikacije virusa gripa |
ES2602972T3 (es) * | 2010-09-08 | 2017-02-23 | Glaxosmithkline Intellectual Property Development Limited | Derivados de indazol para su uso en el tratamiento de infección por virus de la gripe |
CN103562205A (zh) * | 2010-12-16 | 2014-02-05 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
CN103492381A (zh) * | 2010-12-16 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
RU2673064C2 (ru) | 2011-09-01 | 2018-11-22 | Ф. Хоффманн-Ля Рош Аг | Пирролопиразиновые ингибиторы киназы |
WO2013184985A1 (en) * | 2012-06-08 | 2013-12-12 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
NZ719729A (en) | 2013-11-13 | 2022-04-29 | Vertex Pharma | Inhibitors of influenza viruses replication |
AU2015298876B2 (en) | 2014-08-08 | 2020-02-13 | Janssen Sciences Ireland Uc | Indoles for use in influenza virus infection |
UY36255A (es) | 2014-08-08 | 2016-01-29 | Bayer Cropscience Ag | Compuestos sustituidos por halógeno novedosos |
AR101401A1 (es) | 2014-08-08 | 2016-12-14 | Bayer Cropscience Ag | Derivados de bipirazol, sustituidos con halógeno |
CN104592038A (zh) | 2015-01-12 | 2015-05-06 | 烟台万润精细化工股份有限公司 | 一种5,5-二甲基-1,3-环己二胺的制备方法 |
-
2015
- 2015-08-07 AU AU2015298876A patent/AU2015298876B2/en not_active Ceased
- 2015-08-07 CN CN201580042406.9A patent/CN106573920B/zh active Active
- 2015-08-07 WO PCT/EP2015/068257 patent/WO2016020526A1/en active Application Filing
- 2015-08-07 CA CA2954751A patent/CA2954751C/en active Active
- 2015-08-07 SG SG11201700956VA patent/SG11201700956VA/en unknown
- 2015-08-07 EA EA201790266A patent/EA201790266A1/ru unknown
- 2015-08-07 KR KR1020177005979A patent/KR102488479B1/ko active IP Right Grant
- 2015-08-07 MX MX2017001752A patent/MX2017001752A/es unknown
- 2015-08-07 US US15/501,730 patent/US10597390B2/en not_active Expired - Fee Related
- 2015-08-07 MA MA040547A patent/MA40547A/fr unknown
- 2015-08-07 BR BR112017002370-9A patent/BR112017002370B1/pt active IP Right Grant
- 2015-08-07 JP JP2017506964A patent/JP6577570B2/ja active Active
- 2015-08-07 UA UAA201702154A patent/UA124609C2/uk unknown
- 2015-08-07 EP EP15750365.7A patent/EP3177609A1/en not_active Withdrawn
-
2017
- 2017-02-02 IL IL250408A patent/IL250408B/en active IP Right Grant
- 2017-02-02 PH PH12017500207A patent/PH12017500207B1/en unknown
- 2017-02-07 CL CL2017000309A patent/CL2017000309A1/es unknown
- 2017-02-07 ZA ZA2017/00952A patent/ZA201700952B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2015298876B2 (en) | 2020-02-13 |
IL250408A0 (en) | 2017-03-30 |
MX2017001752A (es) | 2018-02-08 |
US20170226102A1 (en) | 2017-08-10 |
WO2016020526A1 (en) | 2016-02-11 |
SG11201700956VA (en) | 2017-03-30 |
MA40547A (fr) | 2017-06-14 |
PH12017500207A1 (en) | 2017-07-10 |
EA201790266A1 (ru) | 2017-06-30 |
IL250408B (en) | 2020-08-31 |
ZA201700952B (en) | 2018-12-19 |
CN106573920A (zh) | 2017-04-19 |
KR102488479B1 (ko) | 2023-01-12 |
JP6577570B2 (ja) | 2019-09-18 |
PH12017500207B1 (en) | 2017-07-10 |
EP3177609A1 (en) | 2017-06-14 |
CL2017000309A1 (es) | 2017-08-18 |
KR20170039275A (ko) | 2017-04-10 |
BR112017002370B1 (pt) | 2022-11-22 |
US10597390B2 (en) | 2020-03-24 |
CA2954751A1 (en) | 2016-02-11 |
CN106573920B (zh) | 2020-11-10 |
UA124609C2 (uk) | 2021-10-20 |
CA2954751C (en) | 2023-01-17 |
JP2017523225A (ja) | 2017-08-17 |
AU2015298876A1 (en) | 2017-02-02 |
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Legal Events
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 07/08/2015, OBSERVADAS AS CONDICOES LEGAIS |