EA201891278A1 - Гетероциклические индолы для применения при инфекции, вызванной вирусом гриппа - Google Patents

Гетероциклические индолы для применения при инфекции, вызванной вирусом гриппа

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Publication number
EA201891278A1
EA201891278A1 EA201891278A EA201891278A EA201891278A1 EA 201891278 A1 EA201891278 A1 EA 201891278A1 EA 201891278 A EA201891278 A EA 201891278A EA 201891278 A EA201891278 A EA 201891278A EA 201891278 A1 EA201891278 A1 EA 201891278A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indols
heterocyclic
infection caused
flu virus
virus
Prior art date
Application number
EA201891278A
Other languages
English (en)
Inventor
Тим Хьюго Мария Йонкерс
Дэвид Крейг Мак Гоуен
Жером Эмиль Жорж Гийемон
Людвиг Поль Коиманс
Вернер Констант Йохан Эмбрехтс
Кристоф Франсис Роберт Нестор Бюйк
Уэнди Миа Альберт Балеманс
Пьер Жан-Мари Бернар Рабуассон
Original Assignee
Янссен Сайенсиз Айрлэнд Юси
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Сайенсиз Айрлэнд Юси filed Critical Янссен Сайенсиз Айрлэнд Юси
Publication of EA201891278A1 publication Critical patent/EA201891278A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Настоящее изобретение относится к соединению формулы (I), которое можно применять для лечения инфекций, вызванных вирусом гриппа, или их предупреждения
EA201891278A 2015-11-27 2016-11-25 Гетероциклические индолы для применения при инфекции, вызванной вирусом гриппа EA201891278A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15196811 2015-11-27
PCT/EP2016/078778 WO2017089518A1 (en) 2015-11-27 2016-11-25 Heterocyclic indoles for use in influenza virus infection

Publications (1)

Publication Number Publication Date
EA201891278A1 true EA201891278A1 (ru) 2018-11-30

Family

ID=54707665

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891278A EA201891278A1 (ru) 2015-11-27 2016-11-25 Гетероциклические индолы для применения при инфекции, вызванной вирусом гриппа

Country Status (16)

Country Link
US (1) US10626108B2 (ru)
EP (1) EP3380467B1 (ru)
JP (1) JP6903658B2 (ru)
KR (1) KR20180087290A (ru)
CN (1) CN108290869B (ru)
AU (1) AU2016359907B2 (ru)
CA (1) CA3005514A1 (ru)
DK (1) DK3380467T3 (ru)
EA (1) EA201891278A1 (ru)
ES (1) ES2882671T3 (ru)
HR (1) HRP20211223T1 (ru)
HU (1) HUE055200T2 (ru)
LT (1) LT3380467T (ru)
MA (1) MA43298A (ru)
SI (1) SI3380467T1 (ru)
WO (1) WO2017089518A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS55341B1 (sr) 2009-06-17 2017-03-31 Vertex Pharma Inhibitori replikacije virusa gripa
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
EP3294735B8 (en) 2015-05-13 2022-01-05 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
LT3405466T (lt) 2016-01-20 2021-01-25 Janssen Sciences Ireland Unlimited Company Arilu pakeistieji pirimidinai, skirti naudoti gripo viruso infekcijos atveju
CN107759571B (zh) 2016-08-16 2021-03-02 广东东阳光药业有限公司 流感病毒复制抑制剂及其使用方法和用途
WO2018041091A1 (en) 2016-08-30 2018-03-08 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
CN108218873B (zh) 2016-12-15 2020-07-07 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途
EP3557998B1 (en) * 2016-12-23 2023-08-16 Aquinnah Pharmaceuticals Inc. Compouns, compositions and methods of use
US11098042B2 (en) 2017-01-05 2021-08-24 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
WO2018157830A1 (en) 2017-03-02 2018-09-07 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG151327A1 (en) 2005-09-30 2009-04-30 Vertex Pharmaceuticals Incopor Deazapurines useful as inhibitors of janus kinases
JP2009541318A (ja) * 2006-06-22 2009-11-26 メルク エンド カムパニー インコーポレーテッド チロシンキナーゼ阻害剤
WO2008095999A1 (en) 2007-02-08 2008-08-14 Tibotec Pharmaceuticals Ltd. Pyrimidine substituted macrocyclic hcv inhibitors
RS55341B1 (sr) 2009-06-17 2017-03-31 Vertex Pharma Inhibitori replikacije virusa gripa
ES2602972T3 (es) 2010-09-08 2017-02-23 Glaxosmithkline Intellectual Property Development Limited Derivados de indazol para su uso en el tratamiento de infección por virus de la gripe
CN103562205A (zh) * 2010-12-16 2014-02-05 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
ES2887303T3 (es) 2011-04-08 2021-12-22 Janssen Sciences Ireland Unlimited Co Derivados de pirimidina para el tratamiento de infecciones víricas
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
WO2013184985A1 (en) 2012-06-08 2013-12-12 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
AR093020A1 (es) 2012-10-16 2015-05-13 Janssen R&D Ireland Compuestos antiviricos para el vsr
CN105189468B (zh) 2013-02-21 2018-10-30 爱尔兰詹森科学公司 用于治疗病毒性感染的2-氨基嘧啶衍生物
LT3405466T (lt) 2016-01-20 2021-01-25 Janssen Sciences Ireland Unlimited Company Arilu pakeistieji pirimidinai, skirti naudoti gripo viruso infekcijos atveju

Also Published As

Publication number Publication date
CA3005514A1 (en) 2017-06-01
JP2019501879A (ja) 2019-01-24
ES2882671T3 (es) 2021-12-02
US10626108B2 (en) 2020-04-21
EP3380467A1 (en) 2018-10-03
US20180258074A1 (en) 2018-09-13
WO2017089518A1 (en) 2017-06-01
AU2016359907B2 (en) 2021-04-01
AU2016359907A1 (en) 2018-05-24
MA43298A (fr) 2021-04-14
HUE055200T2 (hu) 2021-11-29
CN108290869B (zh) 2021-05-18
JP6903658B2 (ja) 2021-07-14
DK3380467T3 (da) 2021-09-27
HRP20211223T1 (hr) 2021-11-12
SI3380467T1 (sl) 2021-08-31
EP3380467B1 (en) 2021-07-07
LT3380467T (lt) 2021-08-10
CN108290869A (zh) 2018-07-17
KR20180087290A (ko) 2018-08-01

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