BR112017004153A2 - métodos para tratamento de infecções por protozoários - Google Patents

métodos para tratamento de infecções por protozoários

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Publication number
BR112017004153A2
BR112017004153A2 BR112017004153A BR112017004153A BR112017004153A2 BR 112017004153 A2 BR112017004153 A2 BR 112017004153A2 BR 112017004153 A BR112017004153 A BR 112017004153A BR 112017004153 A BR112017004153 A BR 112017004153A BR 112017004153 A2 BR112017004153 A2 BR 112017004153A2
Authority
BR
Brazil
Prior art keywords
methods
treating
protozoan infections
subject
formula
Prior art date
Application number
BR112017004153A
Other languages
English (en)
Other versions
BR112017004153B1 (pt
Inventor
Mccluskey Adam
Stevens Andrew
Keenan Martine
Abraham Rebecca
Page Stephen
Original Assignee
Neoculi Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2014903503A external-priority patent/AU2014903503A0/en
Application filed by Neoculi Pty Ltd filed Critical Neoculi Pty Ltd
Publication of BR112017004153A2 publication Critical patent/BR112017004153A2/pt
Publication of BR112017004153B1 publication Critical patent/BR112017004153B1/pt

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    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract

a invenção fornece compostos da fórmula (i), e seu uso em métodos de tratamento ou prevenção de uma infecção por protozoários em um sujeito usando um composto da fórmula (i). a invenção também fornece o uso de um composto da fórmula (i) na fabricação de um medicamento para o tratamento de uma infecção por protozoários em um sujeito. a invenção fornece ainda um dispositivo médico usado em um método de tratamento ou prevenção de uma infecção por protozoários em um sujeito e um dispositivo médico que compreende a composição da invenção.
BR112017004153-7A 2014-09-02 2015-08-28 Uso de uma quantidade terapeuticamente eficaz de um composto, composição farmacêutica antiprotozoária, uso de um dispositivo médico, composto e composição BR112017004153B1 (pt)

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AU2014903503 2014-09-02
AU2014903503A AU2014903503A0 (en) 2014-09-02 Methods For Treating Protozoan Infections
PCT/AU2015/000527 WO2016033635A1 (en) 2014-09-02 2015-08-28 Methods for treating protozoan infections

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BR112017004153A2 true BR112017004153A2 (pt) 2017-12-05
BR112017004153B1 BR112017004153B1 (pt) 2023-03-28

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CA2959440C (en) * 2014-09-02 2024-04-30 Neoculi Pty Ltd Aminoguanidine compounds to treat protozoan infections
US11166464B2 (en) * 2017-03-06 2021-11-09 The United States Of America, As Represented By The Secretary Of Agriculture Self-assembled active agents
CO2017003412A1 (es) * 2017-04-07 2018-10-10 Univ Industrial De Santander Formulación farmacéutica tópica
CN110496121A (zh) * 2019-08-23 2019-11-26 西南大学 二氢青蒿素衍生物在制备抗利什曼原虫的药物中的应用
US20240139190A1 (en) * 2019-10-18 2024-05-02 The Board Of Regents Of The University Of Texas System Novel antiparasitic compounds and methods
CN110812360B (zh) * 2019-11-28 2022-10-11 陕西省微生物研究所 白藜芦醇联合酮康唑在制备抗真菌产品中的应用
US11253534B2 (en) 2020-03-23 2022-02-22 Sabine Hazan Method of preventing COVID-19 infection
US11744866B2 (en) 2020-03-18 2023-09-05 Sabine Hazan Methods of preventing and treating COVID-19 infection with probiotics
US11278520B2 (en) 2020-03-31 2022-03-22 Sabine Hazan Method of preventing COVID-19 infection
EP4138804A1 (en) * 2020-04-24 2023-03-01 Neoculi Pty Ltd Methods and compositions for treating fungal infections
US20220267258A1 (en) * 2021-02-03 2022-08-25 Oregon Health & Science University Robenidine analogs as potent antimalarials against drug-resistant plasmodium falciparum

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US3A (en) * 1836-08-11 Thomas blanchard
CA927394A (en) * 1968-07-01 1973-05-29 American Cyanamid Company Substituted guanidines, compositions and method of preparation
ZA708675B (en) * 1970-12-28 1971-10-27 American Cyanamid Co Compositions of substituted guanidines and method of use thereof
US3897563A (en) * 1972-03-24 1975-07-29 Merck & Co Inc Anticoccidial composition
US3795692A (en) 1972-03-24 1974-03-05 Merck & Co Inc Compounds and processes
US3992446A (en) * 1973-07-27 1976-11-16 American Cyanamid Company Substituted aminochlorobenzylamino guanidine compounds
US4015016A (en) * 1975-02-03 1977-03-29 The Dow Chemical Company [(2-Alkoxyberzylidine)amino]quanidines and their anticoccidal use
US4310541A (en) * 1980-09-22 1982-01-12 Merck & Co., Inc. Method of treating giardiasis and trichomoniasis
AU4923093A (en) 1992-09-11 1994-04-12 Regents Of The University Of California, The Inhibitors of metazoan parasite proteases
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US10392363B2 (en) 2019-08-27
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US10829468B2 (en) 2020-11-10
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CA2959440A1 (en) 2016-03-10
US20210009552A1 (en) 2021-01-14
RU2017109719A (ru) 2018-10-04
CN107106524B (zh) 2021-06-01
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EP3188722A4 (en) 2018-06-13
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US20200290990A1 (en) 2020-09-17
US20200102287A1 (en) 2020-04-02
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US20190330178A1 (en) 2019-10-31
US10752606B2 (en) 2020-08-25
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