EA201790495A1 - Фармацевтические композиции длительного действия - Google Patents

Фармацевтические композиции длительного действия

Info

Publication number
EA201790495A1
EA201790495A1 EA201790495A EA201790495A EA201790495A1 EA 201790495 A1 EA201790495 A1 EA 201790495A1 EA 201790495 A EA201790495 A EA 201790495A EA 201790495 A EA201790495 A EA 201790495A EA 201790495 A1 EA201790495 A1 EA 201790495A1
Authority
EA
Eurasian Patent Office
Prior art keywords
long
pharmaceutical compositions
term action
term
action
Prior art date
Application number
EA201790495A
Other languages
English (en)
Inventor
Брайан Элвин Джонс
Original Assignee
Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54256799&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201790495(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед filed Critical Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед
Publication of EA201790495A1 publication Critical patent/EA201790495A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Настоящее изобретение относится к фармацевтическим композициям длительного действия или их фармацевтически приемлемым солям, полезным в лечении или предупреждении инфекций, вызываемых вирусом иммунодефицита человека (ВИЧ).
EA201790495A 2014-09-26 2015-09-24 Фармацевтические композиции длительного действия EA201790495A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462055779P 2014-09-26 2014-09-26
PCT/IB2015/057360 WO2016046786A1 (en) 2014-09-26 2015-09-24 Long acting pharmaceutical compositions

Publications (1)

Publication Number Publication Date
EA201790495A1 true EA201790495A1 (ru) 2017-09-29

Family

ID=54256799

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790495A EA201790495A1 (ru) 2014-09-26 2015-09-24 Фармацевтические композиции длительного действия

Country Status (18)

Country Link
US (1) US10092523B2 (ru)
EP (1) EP3197430A1 (ru)
JP (1) JP2017528497A (ru)
KR (1) KR20170056702A (ru)
CN (1) CN106999425A (ru)
AU (1) AU2015323321A1 (ru)
BR (1) BR112017006005A2 (ru)
CA (1) CA2961528A1 (ru)
CL (1) CL2017000714A1 (ru)
CR (1) CR20170113A (ru)
DO (1) DOP2017000086A (ru)
EA (1) EA201790495A1 (ru)
IL (1) IL251337A0 (ru)
MX (1) MX2017003928A (ru)
PE (1) PE20170691A1 (ru)
SG (1) SG11201702379TA (ru)
WO (1) WO2016046786A1 (ru)
ZA (1) ZA201702086B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3387B1 (ar) 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين
PE20151326A1 (es) 2012-12-14 2015-10-12 Glaxosmithkline Llc Composiciones farmaceuticas que comprenden derivados de betulina
US10092523B2 (en) 2014-09-26 2018-10-09 Glaxosmithkline Intellectual Property (No. 2) Limited Long acting pharmaceutical compositions
SG11201804037XA (en) * 2015-11-16 2018-06-28 Evonik Roehm Gmbh Injection solution comprising a non-nucleoside reverse-transcriptase inhibitor and poly(lactide-co-glycolide)
CN107184551B (zh) * 2017-06-09 2020-09-01 甘肃新天马制药股份有限公司 一种利拉萘酯双粒径分布乳剂及其制备方法
CA3070319A1 (en) * 2017-07-21 2019-01-24 Viiv Healthcare Company Regimens for treating hiv infections and aids
WO2021116872A1 (en) * 2019-12-09 2021-06-17 Viiv Healthcare Company Pharmaceutical compositions comprising cabotegravir
CN115844838B (zh) * 2022-12-01 2023-10-24 浙江萃泽医药科技有限公司 一种可注射的药物组合物

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8815265D0 (en) 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
US5358721A (en) 1992-12-04 1994-10-25 Alza Corporation Antiviral therapy
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
AU2001262489A1 (en) 2000-05-23 2001-12-03 Univerzita Karlova V Praze Triterpenoid derivatives
DE10103810A1 (de) 2001-01-29 2002-08-01 Map Gmbh Vorrichtung zur Zufuhr eines Atemgases
US7163700B2 (en) 2001-07-31 2007-01-16 Capricorn Pharma, Inc. Amorphous drug beads
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
US20080206161A1 (en) 2002-10-25 2008-08-28 Dov Tamarkin Quiescent foamable compositions, steroids, kits and uses thereof
US20050142205A1 (en) 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
US20060019934A1 (en) * 2004-05-20 2006-01-26 Saxena Brij B Anti-HIV-1 activity of betulinol derivatives
US7150323B2 (en) 2004-07-26 2006-12-19 Vetco Gray Inc. Shoulder ring set on casing hanger trip
TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
WO2006105356A2 (en) 2005-03-29 2006-10-05 Regents Of The University Of Minnesota Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid
TWI457136B (zh) * 2005-04-04 2014-10-21 Tibotec Pharm Ltd Ｈｉｖ-感染之預防
WO2006117666A2 (en) 2005-04-29 2006-11-09 Pfizer Inc. Dosage forms, pharmaceutical compositions and methods for sub-tenon delivery
WO2007098247A2 (en) 2006-02-21 2007-08-30 Achillion Pharmaceuticals, Inc. Substituted taraxastanes useful for treating viral infections
FI121468B (fi) 2006-06-07 2010-11-30 Valtion Teknillinen Betuliiniperäiset yhdisteet antimikrobisina aineina
PL2040671T3 (pl) * 2006-06-23 2018-08-31 Janssen Sciences Ireland Uc Wodne zawiesiny TMC278
WO2008127364A2 (en) 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
CA2668452A1 (en) 2006-11-03 2008-05-15 Panacos Pharmaceuticals, Inc. Extended triterpene derivatives
WO2009082818A1 (en) 2008-01-03 2009-07-09 Virochem Pharma Inc. Novel c-21-keto lupane derivatives preparation and use thereof
JP2011508748A (ja) 2008-01-03 2011-03-17 バイロケム ファーマ インコーポレイテッド 新規のルパン誘導体
DE102008037025C5 (de) 2008-08-08 2016-07-07 Jesalis Pharma Gmbh Verfahren zur Herstellung kristalliner Wirkstoff-Mikropartikel bzw. einer Wirkstoffpartikel-Festkörperform
US8778990B2 (en) 2008-11-04 2014-07-15 Trustees Of Dartmouth College Betulinic acid derivatives and methods of use thereof
CZ2008723A3 (cs) 2008-11-13 2010-01-13 Univerzita Palackého v Olomouci 2-Deoxyglykosidy triterpenoidu, zpusob jejich prípravy a jejich použití jako lécivo
SG171308A1 (en) 2008-12-11 2011-07-28 Shionogi & Co Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates
US8802727B2 (en) 2009-07-14 2014-08-12 Hetero Research Foundation, Hetero Drugs Limited Pharmaceutically acceptable salts of betulinic acid derivatives
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
US20110051713A1 (en) 2009-08-27 2011-03-03 Xerox Corporation Facsimile prioritization within internet protocol call networks
MX2012009319A (es) * 2010-02-11 2012-09-12 Glaxosmithkline Llc Derivados de betulina.
TWI577377B (zh) * 2010-09-16 2017-04-11 Ｖｉｉｖ醫療保健公司 醫藥組合物
WO2013020246A1 (en) 2011-08-08 2013-02-14 Glaxosmithkline Llc Methylene derivatives of betulin
WO2013020245A1 (en) 2011-08-08 2013-02-14 Glaxosmithkline Llc Carbonyl derivatives of betulin
RU2613554C2 (ru) 2011-12-14 2017-03-17 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Пропеноатные производные бетулина
JO3387B1 (ar) 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين
CN104844679B (zh) 2011-12-16 2017-03-01 葛兰素史克有限责任公司 白桦脂醇的衍生物
WO2014035945A1 (en) 2012-08-28 2014-03-06 Glaxosmithkline Llc Pharmaceutical compositions
PE20151326A1 (es) 2012-12-14 2015-10-12 Glaxosmithkline Llc Composiciones farmaceuticas que comprenden derivados de betulina
US10092523B2 (en) 2014-09-26 2018-10-09 Glaxosmithkline Intellectual Property (No. 2) Limited Long acting pharmaceutical compositions

Also Published As

Publication number Publication date
IL251337A0 (en) 2017-05-29
US20170246118A1 (en) 2017-08-31
US10092523B2 (en) 2018-10-09
WO2016046786A1 (en) 2016-03-31
ZA201702086B (en) 2019-06-26
PE20170691A1 (es) 2017-06-13
KR20170056702A (ko) 2017-05-23
EP3197430A1 (en) 2017-08-02
SG11201702379TA (en) 2017-04-27
DOP2017000086A (es) 2017-06-30
JP2017528497A (ja) 2017-09-28
BR112017006005A2 (pt) 2017-12-19
CA2961528A1 (en) 2016-03-31
CL2017000714A1 (es) 2017-11-03
CR20170113A (es) 2017-05-26
AU2015323321A1 (en) 2017-04-13
MX2017003928A (es) 2017-06-28
CN106999425A (zh) 2017-08-01

Similar Documents

Publication Publication Date Title
EA201590862A1 (ru) Фармацевтические композиции
EA201891186A1 (ru) Антитела, нейтрализующие вирус иммунодефицита человека
EA201790495A1 (ru) Фармацевтические композиции длительного действия
EA201790630A1 (ru) Способы получения рибозидов
EA201790266A1 (ru) Индолы для применения при инфекции, вызванной вирусом гриппа
EA201591524A1 (ru) Производные 2-аминопиримидина для лечения вирусных инфекций
MD20170070A2 (ru) Производные хиназолина, используемые при лечении ВИЧ
EA201690687A1 (ru) Ингибиторы репликации вируса иммунодефицита
EA201591887A1 (ru) Макроциклические деазаоксипурины для лечения вирусных инфекций
MX2016016666A (es) Derivados de acido boronico y usos terapeuticos de los mismos.
EA201992133A1 (ru) Производные пиперидино-пиримидина для лечения вирусных инфекций
NZ732391A (en) Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
MX2016015093A (es) Derivados de acido boronico y sus usos terapeuticos.
UY35263A (es) Compuestos terapéuticos
EA201590931A1 (ru) Гетероциклические замещенные производные 2-амино-хиназолина для лечения вирусных инфекций
PH12015502539B1 (en) Cenicriviroc compositions and methods of making and using the same
EA201500383A1 (ru) Производные 1,2,4-триазина для лечения вирусных инфекций
BR112017013440A2 (pt) compostos de isoquinolina para o tratamento de hiv
EA201790571A1 (ru) Пирролопиримидины для применения при инфекции, вызванной вирусом гриппа
IN2013MU01749A (ru)
EA201591406A1 (ru) C-19 модифицированные тритерпеноиды с ингибиторной активностью созревания вич
CO2018001359A2 (es) Derivados del ácido 5-(n-bencil-tetrahidroisoquinolin-6-il)-piridin-3-il acético como inhibidores de la replicación del virus de la inmunodeficiencia humana
CR20160529A (es) Composiciones farmacéuticas para tratar enfermedades infecciosas
IN2014MU00916A (ru)
EA201592242A1 (ru) Производные пиридона для лечения вирусных инфекций и других заболеваний