EA201691945A1 - Антитела к гемагглютинину вируса гриппа типа b и способы их применения - Google Patents

Антитела к гемагглютинину вируса гриппа типа b и способы их применения

Info

Publication number
EA201691945A1
EA201691945A1 EA201691945A EA201691945A EA201691945A1 EA 201691945 A1 EA201691945 A1 EA 201691945A1 EA 201691945 A EA201691945 A EA 201691945A EA 201691945 A EA201691945 A EA 201691945A EA 201691945 A1 EA201691945 A1 EA 201691945A1
Authority
EA
Eurasian Patent Office
Prior art keywords
virus
antibodies
hemagglutinin
methods
type
Prior art date
Application number
EA201691945A
Other languages
English (en)
Inventor
Ли Свем
Минь СЮЙ
Мерседес Балаж
Нин Чай
Нэнси Чиан
Генри ЧИУ
Чжунхуа Линь
Джеральд Р. Накамура
Хёнджу Парк
Original Assignee
Дженентек, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дженентек, Инк. filed Critical Дженентек, Инк.
Publication of EA201691945A1 publication Critical patent/EA201691945A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Описаны антитела к гемагглютинину вируса гриппа типа В, композиции, содержащие антитела к гемагглютинину вируса гриппа типа В и способы их применения.
EA201691945A 2014-03-27 2015-03-26 Антитела к гемагглютинину вируса гриппа типа b и способы их применения EA201691945A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461971123P 2014-03-27 2014-03-27
PCT/US2015/022758 WO2015148806A1 (en) 2014-03-27 2015-03-26 Anti-influenza b virus hemagglutinin antibodies and methods of use

Publications (1)

Publication Number Publication Date
EA201691945A1 true EA201691945A1 (ru) 2017-02-28

Family

ID=52829396

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691945A EA201691945A1 (ru) 2014-03-27 2015-03-26 Антитела к гемагглютинину вируса гриппа типа b и способы их применения

Country Status (20)

Country Link
US (2) US9745365B2 (ru)
EP (1) EP3122771A1 (ru)
JP (1) JP2017512471A (ru)
KR (1) KR20160135830A (ru)
CN (1) CN106132987A (ru)
AR (1) AR099855A1 (ru)
AU (1) AU2015235983A1 (ru)
BR (1) BR112016022113A2 (ru)
CA (1) CA2942820A1 (ru)
CL (2) CL2016002413A1 (ru)
CR (1) CR20160502A (ru)
EA (1) EA201691945A1 (ru)
IL (1) IL247870A0 (ru)
MA (1) MA39803A (ru)
MX (1) MX2016012530A (ru)
PE (1) PE20161376A1 (ru)
PH (1) PH12016501873A1 (ru)
SG (1) SG11201607945UA (ru)
TW (1) TW201620932A (ru)
WO (1) WO2015148806A1 (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109154014A (zh) 2016-05-10 2019-01-04 豪夫迈·罗氏有限公司 重组产生多肽期间减少三硫键的方法
AU2018392728A1 (en) 2017-12-22 2020-07-09 Genentech, Inc. Targeted integration of nucleic acids
CA3088194A1 (en) 2018-01-26 2019-08-01 Regeneron Pharmaceuticals, Inc. Human antibodies to influenza hemagglutinin
JP2021519073A (ja) 2018-03-29 2021-08-10 ジェネンテック， インコーポレイテッド 哺乳動物細胞におけるラクトジェニック活性の制御
KR20210107057A (ko) 2018-12-21 2021-08-31 제넨테크, 인크. 핵산의 표적화 통합
RU2714246C1 (ru) * 2018-12-28 2020-02-13 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт гриппа имени А.А. Смородинцева" Министерства здравоохранения Российской Федерации Моноклональные антитела, специфичные к различным штаммам вируса гриппа в
BR112022007923A2 (pt) * 2019-10-28 2022-07-26 Regeneron Pharma Anticorpo recombinante isolado ou fragmento de ligação ao antígeno deste, composição farmacêutica, molécula de polinucleotídeo, vetor, célula, e, método para prevenir, tratar ou melhorar pelo menos um sintoma da infecção por influenza
CN115348874A (zh) * 2020-01-24 2022-11-15 里珍纳龙药品有限公司 蛋白质-抗病毒化合物偶联物
TW202202620A (zh) 2020-03-26 2022-01-16 美商建南德克公司 經修飾之哺乳動物細胞
MX2022016453A (es) 2020-06-24 2023-02-01 Genentech Inc Lineas celulares resistentes a la apoptosis.
CN116096907A (zh) 2020-06-24 2023-05-09 基因泰克公司 核酸的靶向整合
EP4204558A2 (en) 2020-08-28 2023-07-05 Genentech, Inc. Crispr/cas9 multiplex knockout of host cell proteins
CN114316032B (zh) * 2020-09-27 2022-12-27 东莞市朋志生物科技有限公司 抗乙型流感病毒的抗体、检测乙型流感病毒的试剂和试剂盒
CA3215965A1 (en) 2021-04-19 2022-10-27 Amy Shen Modified mammalian cells
JP2024521107A (ja) 2021-05-21 2024-05-28 ジェネンテック， インコーポレイテッド 目的の組換え産物を産生するための修飾細胞
WO2024104947A2 (en) 2022-11-14 2024-05-23 Janssen Vaccines & Prevention B.V. Influenza b virus vaccines and uses thereof
WO2024107879A1 (en) 2022-11-15 2024-05-23 Genentech, Inc. Combined transposon-mediated integration and targeted integration of nucleic acids into host cells
US20240240175A1 (en) 2023-01-12 2024-07-18 Genentech, Inc. Combinatorial vector cloning and transfection strategies for targeted integration of nucleic acids

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2921928B1 (fr) 2007-10-08 2011-03-04 Sanofi Pasteur Anticorps monoclonaux specifiques de l'hemagglutinine du virus grippal
BE1018561A3 (fr) 2008-12-24 2011-03-01 Galactic Sa Procede de purification de l'acide lactique par cristallisation.
JP5780762B2 (ja) 2008-12-25 2015-09-16 国立大学法人大阪大学 抗ヒトインフルエンザウイルス・ヒト型抗体
BR112014000263B1 (pt) * 2011-07-14 2022-01-18 Janssen Vaccines & Prevention B.V. Anticorpo isolado capaz de se ligar especificamente à proteína hemaglutinina (ha) dos subtipos de vírus influenza b, e, composição farmacêutica que o compreende
US9181328B2 (en) * 2012-01-31 2015-11-10 Osaka University Human monoclonal antibodies broadly protective against influenza B virus and methods of using the same
NZ628382A (en) * 2012-03-08 2017-03-31 Janssen Vaccines & Prevention Bv Human binding molecules capable of binding to and neutralizing influenza b viruses and uses thereof

Also Published As

Publication number Publication date
CR20160502A (es) 2017-02-03
CN106132987A (zh) 2016-11-16
EP3122771A1 (en) 2017-02-01
IL247870A0 (en) 2016-11-30
CA2942820A1 (en) 2015-10-01
US20150274812A1 (en) 2015-10-01
WO2015148806A1 (en) 2015-10-01
US9745365B2 (en) 2017-08-29
BR112016022113A2 (pt) 2017-10-31
US20170320937A1 (en) 2017-11-09
AU2015235983A1 (en) 2016-10-06
CL2018002874A1 (es) 2018-12-14
PH12016501873A1 (en) 2017-01-09
PE20161376A1 (es) 2016-12-26
JP2017512471A (ja) 2017-05-25
SG11201607945UA (en) 2016-10-28
TW201620932A (zh) 2016-06-16
AR099855A1 (es) 2016-08-24
KR20160135830A (ko) 2016-11-28
MA39803A (fr) 2017-02-01
MX2016012530A (es) 2017-01-05
CL2016002413A1 (es) 2017-06-23

Similar Documents

Publication Publication Date Title
EA201691945A1 (ru) Антитела к гемагглютинину вируса гриппа типа b и способы их применения
CY1123358T1 (el) Υδατικο φαρμακευτικο σκευασμα που περιεχει αντισωμα αντι-pd-1 αβελουμαμπη
EA201790630A1 (ru) Способы получения рибозидов
EA202091898A1 (ru) Антитела, нейтрализующие вирус иммунодефицита человека
EA201792500A1 (ru) Aav-опосредованная экспрессия антител против гриппа и способы их использования
EA201692467A1 (ru) Вакцины против вируса гриппа и их применения
EA201791460A1 (ru) N4-гидроксицитидин и связанные с ним производные и варианты противовирусного применения
EA201691610A1 (ru) Анти-jagged1 антитела и способы применения
EA201691974A1 (ru) Антитела против ox40 и способы их применения
CL2016002455A1 (es) Anticuerpos multiespecíficos.
EA201791029A1 (ru) Антитела против интерлейкина-33 и их применение
EA201890712A1 (ru) Антитела к про-/латентному миостатину и их применения
EA201691582A1 (ru) Новые фармацевтические препараты
EA201892509A1 (ru) Антитела к гемагглютинину и способы применения
EA201591164A1 (ru) Вакцины против вируса гриппа и их применение
EA201790984A1 (ru) Анти-cd79b антитела и способы их применения
EA201690667A1 (ru) Композиции, содержащие антитело к pdl1
EA201790266A1 (ru) Индолы для применения при инфекции, вызванной вирусом гриппа
EA201591728A1 (ru) Гетероциклические соединения и способы их применения
EA201491947A1 (ru) Антитела и иммуноконъюгаты к ly6e и способы применения
BR112017005266A2 (pt) inibidores de mk2 e uso dos mesmos
EA202091397A1 (ru) Бензохинолоновые ингибиторы vmat2
EA201692541A1 (ru) Вакцины против вируса гриппа и их применения
MX2017004975A (es) Composiciones de anticuerpos anti-il-7r.
EA201790650A1 (ru) Лекарственная форма и способы применения абиратерона ацетата