SA519401435B1 - مركبات حلقية ثنائية النيوكليوتيد - Google Patents
مركبات حلقية ثنائية النيوكليوتيدInfo
- Publication number
- SA519401435B1 SA519401435B1 SA519401435A SA519401435A SA519401435B1 SA 519401435 B1 SA519401435 B1 SA 519401435B1 SA 519401435 A SA519401435 A SA 519401435A SA 519401435 A SA519401435 A SA 519401435A SA 519401435 B1 SA519401435 B1 SA 519401435B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- cyclic dinucleotide
- dinucleotide compounds
- sting
- compounds
- stimulator
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
يتعلق الاختراع الحالي بمركبات ثُنائِيُّ النُّوكْلِيُوتيد الحلقية الجديدة من الصيغة (I)، ، التي تتميز بخصائص صيدلانية قيمة، وبشكل خاص كمعدلات محفز جينات الإنترفيرون modulators of Stimulator of Interferon Genes (STING) واستخدامها الطبي لمعالجة الامراض المرتبطة بمعدلات محفز جينات الإنترفيرون.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16191919 | 2016-09-30 | ||
PCT/EP2017/074608 WO2018060323A1 (en) | 2016-09-30 | 2017-09-28 | Cyclic dinucleotide compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SA519401435B1 true SA519401435B1 (ar) | 2022-08-01 |
Family
ID=57103851
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA519401435A SA519401435B1 (ar) | 2016-09-30 | 2019-03-27 | مركبات حلقية ثنائية النيوكليوتيد |
Country Status (33)
Country | Link |
---|---|
US (1) | US10537590B2 (ar) |
EP (1) | EP3519420B1 (ar) |
JP (1) | JP6509445B2 (ar) |
KR (2) | KR20220084206A (ar) |
CN (1) | CN109843903B (ar) |
AR (1) | AR109777A1 (ar) |
AU (1) | AU2017333933B2 (ar) |
BR (1) | BR112019006512A2 (ar) |
CA (1) | CA3038860C (ar) |
CL (1) | CL2019000775A1 (ar) |
CO (1) | CO2019003178A2 (ar) |
CY (1) | CY1124638T1 (ar) |
DK (1) | DK3519420T3 (ar) |
EA (1) | EA037030B1 (ar) |
ES (1) | ES2848724T3 (ar) |
HR (1) | HRP20210027T1 (ar) |
HU (1) | HUE053819T2 (ar) |
IL (1) | IL265642B (ar) |
JO (1) | JOP20190066B1 (ar) |
LT (1) | LT3519420T (ar) |
MA (1) | MA46325B1 (ar) |
MX (1) | MX2019003586A (ar) |
NZ (1) | NZ750906A (ar) |
PE (1) | PE20191503A1 (ar) |
PH (1) | PH12019500706A1 (ar) |
PL (1) | PL3519420T3 (ar) |
PT (1) | PT3519420T (ar) |
RS (1) | RS61423B1 (ar) |
SA (1) | SA519401435B1 (ar) |
SI (1) | SI3519420T1 (ar) |
TW (1) | TWI774697B (ar) |
UA (1) | UA124347C2 (ar) |
WO (1) | WO2018060323A1 (ar) |
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2017
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