MX2019003586A - Compuestos de dinucleotidos ciclicos. - Google Patents

Compuestos de dinucleotidos ciclicos.

Info

Publication number
MX2019003586A
MX2019003586A MX2019003586A MX2019003586A MX2019003586A MX 2019003586 A MX2019003586 A MX 2019003586A MX 2019003586 A MX2019003586 A MX 2019003586A MX 2019003586 A MX2019003586 A MX 2019003586A MX 2019003586 A MX2019003586 A MX 2019003586A
Authority
MX
Mexico
Prior art keywords
compounds
cyclic dinucleotide
relates
dinucleotide compounds
sting
Prior art date
Application number
MX2019003586A
Other languages
English (en)
Inventor
Oost Thorsten
Fleck Martin
Carotta Sebastian
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2019003586A publication Critical patent/MX2019003586A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula general (I), (Ver fórmula) en donde los grupos R', R2 y R3 se definen como en la reivindicación 1, que tiene propiedades farmacológicas valiosas, en particular son moduladores de STING.
MX2019003586A 2016-09-30 2017-09-28 Compuestos de dinucleotidos ciclicos. MX2019003586A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16191919 2016-09-30
PCT/EP2017/074608 WO2018060323A1 (en) 2016-09-30 2017-09-28 Cyclic dinucleotide compounds

Publications (1)

Publication Number Publication Date
MX2019003586A true MX2019003586A (es) 2019-06-10

Family

ID=57103851

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019003586A MX2019003586A (es) 2016-09-30 2017-09-28 Compuestos de dinucleotidos ciclicos.

Country Status (33)

Country Link
US (1) US10537590B2 (es)
EP (1) EP3519420B1 (es)
JP (1) JP6509445B2 (es)
KR (2) KR20220084206A (es)
CN (1) CN109843903B (es)
AR (1) AR109777A1 (es)
AU (1) AU2017333933B2 (es)
BR (1) BR112019006512A2 (es)
CA (1) CA3038860C (es)
CL (1) CL2019000775A1 (es)
CO (1) CO2019003178A2 (es)
CY (1) CY1124638T1 (es)
DK (1) DK3519420T3 (es)
EA (1) EA037030B1 (es)
ES (1) ES2848724T3 (es)
HR (1) HRP20210027T1 (es)
HU (1) HUE053819T2 (es)
IL (1) IL265642B (es)
JO (1) JOP20190066B1 (es)
LT (1) LT3519420T (es)
MA (1) MA46325B1 (es)
MX (1) MX2019003586A (es)
NZ (1) NZ750906A (es)
PE (1) PE20191503A1 (es)
PH (1) PH12019500706A1 (es)
PL (1) PL3519420T3 (es)
PT (1) PT3519420T (es)
RS (1) RS61423B1 (es)
SA (1) SA519401435B1 (es)
SI (1) SI3519420T1 (es)
TW (1) TWI774697B (es)
UA (1) UA124347C2 (es)
WO (1) WO2018060323A1 (es)

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Publication number Publication date
NZ750906A (en) 2022-08-26
PL3519420T4 (pl) 2021-08-16
MA46325B1 (fr) 2021-02-26
CN109843903A (zh) 2019-06-04
JOP20190066A1 (ar) 2019-03-28
US20180092937A1 (en) 2018-04-05
PT3519420T (pt) 2021-02-02
US10537590B2 (en) 2020-01-21
AR109777A1 (es) 2019-01-23
CN109843903B (zh) 2023-01-24
ES2848724T3 (es) 2021-08-11
EA037030B1 (ru) 2021-01-28
UA124347C2 (uk) 2021-09-01
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