EA029856B9 - Циклические динуклеотиды в качестве модуляторов стимулятора генов интерферона (sting) - Google Patents

Циклические динуклеотиды в качестве модуляторов стимулятора генов интерферона (sting)

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Publication number
EA029856B9
EA029856B9 EA201692119A EA201692119A EA029856B9 EA 029856 B9 EA029856 B9 EA 029856B9 EA 201692119 A EA201692119 A EA 201692119A EA 201692119 A EA201692119 A EA 201692119A EA 029856 B9 EA029856 B9 EA 029856B9
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EA
Eurasian Patent Office
Prior art keywords
sting
stimulator
modulators
nucleotides
cyclic
Prior art date
Application number
EA201692119A
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English (en)
Other versions
EA029856B1 (ru
EA201692119A1 (ru
Inventor
Кейт Биггэдайк
Аурелия Сисиль Шампиньи
Дайан Мэри Коу
Дебора Нидхэм
Дэниел Теренс Тейп
Original Assignee
Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед
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Priority claimed from GB201409911A external-priority patent/GB201409911D0/en
Priority claimed from GB201501466A external-priority patent/GB201501466D0/en
Application filed by Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед filed Critical Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед
Publication of EA201692119A1 publication Critical patent/EA201692119A1/ru
Publication of EA029856B1 publication Critical patent/EA029856B1/ru
Publication of EA029856B9 publication Critical patent/EA029856B9/ru

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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
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    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate

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Abstract

Предложено соединение формулы (I)или его фармацевтически приемлемая соль и таутомеры, композиции, комбинации и лекарственные средства, содержащие такие соединения, а также способы их получения. Изобретение также относится к применению указанных соединений, комбинаций, композиций и лекарственных средств в лечении заболеваний и состояний, при которых полезно модулирование стимулятора генов интерферона, например воспаления, аллергических и аутоиммунных заболеваний, инфекционных заболеваний, рака и в качестве вакцинных адъювантов.
EA201692119A 2014-06-04 2015-06-02 Циклические динуклеотиды в качестве модуляторов стимулятора генов интерферона (sting) EA029856B9 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201409911A GB201409911D0 (en) 2014-06-04 2014-06-04 Novel compounds
GB201501466A GB201501466D0 (en) 2015-01-29 2015-01-29 Novel compounds
PCT/EP2015/062281 WO2015185565A1 (en) 2014-06-04 2015-06-02 Cyclic di-nucleotides as modulators of sting

Publications (3)

Publication Number Publication Date
EA201692119A1 EA201692119A1 (ru) 2017-06-30
EA029856B1 EA029856B1 (ru) 2018-05-31
EA029856B9 true EA029856B9 (ru) 2018-08-31

Family

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EA201692119A EA029856B9 (ru) 2014-06-04 2015-06-02 Циклические динуклеотиды в качестве модуляторов стимулятора генов интерферона (sting)

Country Status (18)

Country Link
US (1) US10450341B2 (ru)
EP (1) EP3152217B1 (ru)
JP (1) JP6462006B2 (ru)
KR (1) KR20170015353A (ru)
CN (1) CN106459131B (ru)
AU (1) AU2015270640B2 (ru)
CA (1) CA2950033A1 (ru)
CL (1) CL2016003056A1 (ru)
CR (1) CR20160564A (ru)
DO (1) DOP2016000316A (ru)
EA (1) EA029856B9 (ru)
ES (1) ES2692226T3 (ru)
IL (1) IL248604A0 (ru)
MX (1) MX2016015928A (ru)
PE (1) PE20170198A1 (ru)
PH (1) PH12016502318A1 (ru)
SG (1) SG11201609021QA (ru)
WO (1) WO2015185565A1 (ru)

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