MX2020006237A - Compuestos para el tratamiento de enfermedades relacionadas con la expresion de dux4. - Google Patents

Compuestos para el tratamiento de enfermedades relacionadas con la expresion de dux4.

Info

Publication number
MX2020006237A
MX2020006237A MX2020006237A MX2020006237A MX2020006237A MX 2020006237 A MX2020006237 A MX 2020006237A MX 2020006237 A MX2020006237 A MX 2020006237A MX 2020006237 A MX2020006237 A MX 2020006237A MX 2020006237 A MX2020006237 A MX 2020006237A
Authority
MX
Mexico
Prior art keywords
compounds
treatment
diseases related
dux4 expression
dux4
Prior art date
Application number
MX2020006237A
Other languages
English (en)
Inventor
Monika Ermann
Marcus Geese
Martin Schneider
Maeyer Joris De
Sebastian Monecke
Alexander Kaever
Timothy Robin James
Original Assignee
Facio Intellectual Property B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Facio Intellectual Property B V filed Critical Facio Intellectual Property B V
Publication of MX2020006237A publication Critical patent/MX2020006237A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system

Abstract

La presente invención se refiere a compuestos para el tratamiento de enfermedades relacionadas con la expresión de DUX4, tales como distrofias musculares. También se refiere al uso de tales compuestos, o a métodos de uso de tales compuestos.
MX2020006237A 2017-12-13 2018-12-13 Compuestos para el tratamiento de enfermedades relacionadas con la expresion de dux4. MX2020006237A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17207162 2017-12-13
PCT/EP2018/084802 WO2019115711A1 (en) 2017-12-13 2018-12-13 Compounds for treatment of diseases related to dux4 expression

Publications (1)

Publication Number Publication Date
MX2020006237A true MX2020006237A (es) 2020-11-06

Family

ID=60673528

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006237A MX2020006237A (es) 2017-12-13 2018-12-13 Compuestos para el tratamiento de enfermedades relacionadas con la expresion de dux4.

Country Status (13)

Country Link
US (3) US10973820B2 (es)
EP (2) EP3723756A1 (es)
JP (1) JP2021506765A (es)
KR (1) KR20200098536A (es)
CN (1) CN111479570A (es)
AU (1) AU2018382974A1 (es)
CA (1) CA3083975A1 (es)
DK (1) DK3498278T3 (es)
ES (1) ES2791539T3 (es)
IL (1) IL275321A (es)
MX (1) MX2020006237A (es)
WO (1) WO2019115711A1 (es)
ZA (1) ZA202003407B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113350353A (zh) 2015-03-23 2021-09-07 墨尔本大学 呼吸性疾病的治疗
US10973820B2 (en) * 2017-12-13 2021-04-13 Facio Intellectual Property B.V. Compounds for treatment of diseases related to DUX4 expression
TW202112368A (zh) * 2019-06-13 2021-04-01 荷蘭商法西歐知識產權股份有限公司 用於治療有關dux4表現之疾病的抑制劑組合
JP2023503322A (ja) * 2019-11-29 2023-01-27 ファシオ インテレクチュアル プロパティ ビー．ヴイ． Ｄｕｘ４発現に関連する疾患を処置するための新規化合物
CA3159250A1 (en) * 2019-11-29 2021-06-03 Facio Intellectual Property B.V. New compounds for treatment of diseases related to dux4 expression
UY39417A (es) 2020-09-11 2022-03-31 Arrowhead Pharmaceuticals Inc Agentes de arni para inhibir la expresión de dux4, composiciones de dichos agentes, y métodos de uso
GB202019622D0 (en) * 2020-12-11 2021-01-27 Adorx Therapeutics Ltd Antagonist compounds
CN116888126A (zh) * 2020-12-15 2023-10-13 北京原基华毅生物科技有限公司 一种酪蛋白激酶抑制剂的化合物
WO2023241552A1 (en) * 2022-06-14 2023-12-21 Gritscience Biopharmaceuticals Co., Ltd Salt and/or crystal form for compounds as casein kinase inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060113754A (ko) 2003-12-11 2006-11-02 아벤티스 파마슈티칼스 인크. 카제인 키나제 Ｉε저해제로서 치환된 1Ｈ-피롤로［3,2-ｂ,3,2-ｃ, 및 2,3-ｃ］피리딘-2-카복사미드 및 관련 유사체
FR2918061B1 (fr) 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
AU2010311035B2 (en) 2009-10-28 2013-05-16 Pfizer Inc. Imidazole derivatives as casein kinase inhibitors
ES2623387T3 (es) * 2010-12-20 2017-07-11 Pfizer Inc. Nuevos compuestos de piridina condensada como inhibidores de la cinasa de caseína
EP2546357A1 (en) 2011-07-14 2013-01-16 Erasmus University Medical Center Rotterdam A new classifier for the molecular classification of multiple myeloma.
WO2014081923A1 (en) 2012-11-21 2014-05-30 The Johns Hopkins University Genomic classifiers for non-invasive identification of high grade prostate cancer with metastatic potential
ES2489297B1 (es) * 2013-01-22 2015-06-10 Consejo Superior De Investigaciones Científicas (Csic) Benzotiazoles sustituidos y sus aplicaciones terapeuticas para el tratamiento de enfermedades humanas
US9814728B2 (en) 2013-09-20 2017-11-14 Saint Louis University Inhibition of DUX4 expression using bromodomain and extra-terminal domain protein inhibitors (BETi)
CN106470699A (zh) * 2014-02-03 2017-03-01 耶路撒冷希伯来大学的益生研究开发有限公司 使用酪蛋白激酶i抑制剂以消耗干细胞的用途
SG11201606427SA (en) 2014-02-07 2016-09-29 Agency Science Tech & Res 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis
ES2770693T3 (es) 2014-06-19 2020-07-02 Bristol Myers Squibb Co Derivados de imidazopiridazina como inhibidores de caseína quinasa 1 delta/épsilon
US10973820B2 (en) * 2017-12-13 2021-04-13 Facio Intellectual Property B.V. Compounds for treatment of diseases related to DUX4 expression

Also Published As

Publication number Publication date
EP3498278A1 (en) 2019-06-19
EP3723756A1 (en) 2020-10-21
JP2021506765A (ja) 2021-02-22
US20220226318A1 (en) 2022-07-21
IL275321A (en) 2020-07-30
WO2019115711A1 (en) 2019-06-20
US10973820B2 (en) 2021-04-13
US20210177847A1 (en) 2021-06-17
EP3498278B1 (en) 2020-03-18
CA3083975A1 (en) 2019-06-20
DK3498278T3 (da) 2020-04-20
KR20200098536A (ko) 2020-08-20
ZA202003407B (en) 2022-06-29
CN111479570A (zh) 2020-07-31
AU2018382974A1 (en) 2020-06-18
US20190175596A1 (en) 2019-06-13
ES2791539T3 (es) 2020-11-04

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