CR20220586A - Moléculas de fijación para el tratamiento de cáncer - Google Patents
Moléculas de fijación para el tratamiento de cáncerInfo
- Publication number
- CR20220586A CR20220586A CR20220586A CR20220586A CR20220586A CR 20220586 A CR20220586 A CR 20220586A CR 20220586 A CR20220586 A CR 20220586A CR 20220586 A CR20220586 A CR 20220586A CR 20220586 A CR20220586 A CR 20220586A
- Authority
- CR
- Costa Rica
- Prior art keywords
- cancer
- treatment
- binding molecules
- same
- fap
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
La presente invención se refiere a moléculas de fijación que se fijan específicamente a CD137 y FAP y su uso medicinal, composiciones farmacéuticas que las contienen y métodos para usarlas como agentes para el tratamiento y/o la prevención de cáncer.<br /> <br />
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063026883P | 2020-05-19 | 2020-05-19 | |
US202063037241P | 2020-06-10 | 2020-06-10 | |
PCT/US2021/032990 WO2021236658A1 (en) | 2020-05-19 | 2021-05-18 | Binding molecules for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20220586A true CR20220586A (es) | 2023-01-09 |
Family
ID=76502807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20220586A CR20220586A (es) | 2020-05-19 | 2021-05-18 | Moléculas de fijación para el tratamiento de cáncer |
Country Status (17)
Country | Link |
---|---|
US (1) | US20210363273A1 (es) |
EP (1) | EP4153316A1 (es) |
JP (2) | JP2023504675A (es) |
KR (1) | KR20230012559A (es) |
CN (1) | CN116249555A (es) |
AU (1) | AU2021276332A1 (es) |
BR (1) | BR112022021447A2 (es) |
CA (1) | CA3180665A1 (es) |
CL (1) | CL2022003213A1 (es) |
CO (1) | CO2022016754A2 (es) |
CR (1) | CR20220586A (es) |
EC (1) | ECSP22085835A (es) |
IL (1) | IL298287A (es) |
MX (1) | MX2022014538A (es) |
PE (1) | PE20230784A1 (es) |
TW (1) | TW202214303A (es) |
WO (1) | WO2021236658A1 (es) |
Family Cites Families (55)
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WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
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CA2150262C (en) | 1992-12-04 | 2008-07-08 | Kaspar-Philipp Holliger | Multivalent and multispecific binding proteins, their manufacture and use |
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US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
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WO1998049198A1 (en) | 1997-04-30 | 1998-11-05 | Enzon, Inc. | Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof |
EP0953639A1 (en) | 1998-04-30 | 1999-11-03 | Boehringer Ingelheim International GmbH | FAPalpha-specific antibody with improved producibility |
EP1268550A2 (en) | 2000-03-17 | 2003-01-02 | Boehringer Ingelheim Pharma KG | Human fap-alpha-specific antibodies |
AU2001266557A1 (en) | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
CA2421447C (en) | 2000-09-08 | 2012-05-08 | Universitat Zurich | Collections of repeat proteins comprising repeat modules |
EP2706116A1 (en) | 2001-01-17 | 2014-03-12 | Emergent Product Development Seattle, LLC | Binding domain-immunoglobulin fusion proteins |
PE20021080A1 (es) | 2001-04-12 | 2003-02-12 | Boehringer Ingelheim Int | Un anticuerpo especifico fapo bibh1 en el tratamiento del cancer |
WO2003050531A2 (en) | 2001-12-11 | 2003-06-19 | Algonomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
JP2006512895A (ja) | 2002-06-28 | 2006-04-20 | ドマンティス リミテッド | リガンド |
MXPA05004955A (es) | 2002-11-08 | 2005-11-17 | Ablynx Nv | Anticuerpos de region unica dirigidos contra el factor-alfa de necrosis de tumor y usos de estos. |
SI1639011T1 (sl) | 2003-06-30 | 2009-04-30 | Domantis Ltd | Pegilirana protitelesa z enojno domeno (dAb) |
PL2439273T3 (pl) | 2005-05-09 | 2019-08-30 | Ono Pharmaceutical Co., Ltd. | Ludzkie przeciwciała monoklonalne przeciwko białku programowanej śmierci komórki 1(pd-1) oraz metody leczenia nowotworów z wykorzystaniem przeciwciał anty-pd-1 samodzielnie lub w połączeniu z innymi immunoterapeutykami |
ME02886B (me) | 2005-10-12 | 2018-04-20 | Morphosys Ag | Proizvodnja i karakterizacija potpuno humanih terapeutskih antitela dobijenih HuCAL GOLD tehnologijom, specifičnih za humani CD38 |
EP1806365A1 (en) | 2006-01-05 | 2007-07-11 | Boehringer Ingelheim International GmbH | Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them |
EP2170959B1 (en) | 2007-06-18 | 2013-10-02 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor pd-1 |
PL2235064T3 (pl) | 2008-01-07 | 2016-06-30 | Amgen Inc | Sposób otrzymywania cząsteczek przeciwciał z heterodimerycznymi fc z zastosowaniem kierujących efektów elektrostatycznych |
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-
2021
- 2021-05-18 CN CN202180035724.8A patent/CN116249555A/zh active Pending
- 2021-05-18 MX MX2022014538A patent/MX2022014538A/es unknown
- 2021-05-18 CA CA3180665A patent/CA3180665A1/en active Pending
- 2021-05-18 IL IL298287A patent/IL298287A/en unknown
- 2021-05-18 BR BR112022021447A patent/BR112022021447A2/pt unknown
- 2021-05-18 PE PE2022002692A patent/PE20230784A1/es unknown
- 2021-05-18 JP JP2022533221A patent/JP2023504675A/ja active Pending
- 2021-05-18 US US17/323,844 patent/US20210363273A1/en active Pending
- 2021-05-18 EP EP21733260.0A patent/EP4153316A1/en active Pending
- 2021-05-18 TW TW110117908A patent/TW202214303A/zh unknown
- 2021-05-18 AU AU2021276332A patent/AU2021276332A1/en active Pending
- 2021-05-18 CR CR20220586A patent/CR20220586A/es unknown
- 2021-05-18 KR KR1020227044045A patent/KR20230012559A/ko unknown
- 2021-05-18 WO PCT/US2021/032990 patent/WO2021236658A1/en active Application Filing
-
2022
- 2022-11-09 EC ECSENADI202285835A patent/ECSP22085835A/es unknown
- 2022-11-17 CL CL2022003213A patent/CL2022003213A1/es unknown
- 2022-11-22 CO CONC2022/0016754A patent/CO2022016754A2/es unknown
-
2024
- 2024-02-09 JP JP2024018456A patent/JP2024054284A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
IL298287A (en) | 2023-01-01 |
CO2022016754A2 (es) | 2022-11-29 |
AU2021276332A1 (en) | 2022-11-17 |
ECSP22085835A (es) | 2022-12-30 |
MX2022014538A (es) | 2022-12-15 |
JP2023504675A (ja) | 2023-02-06 |
EP4153316A1 (en) | 2023-03-29 |
TW202214303A (zh) | 2022-04-16 |
CN116249555A (zh) | 2023-06-09 |
KR20230012559A (ko) | 2023-01-26 |
CA3180665A1 (en) | 2021-11-25 |
CL2022003213A1 (es) | 2023-06-30 |
PE20230784A1 (es) | 2023-05-11 |
BR112022021447A2 (pt) | 2022-12-13 |
JP2024054284A (ja) | 2024-04-16 |
US20210363273A1 (en) | 2021-11-25 |
WO2021236658A1 (en) | 2021-11-25 |
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