BR112018069974A2 - compostos de tiazolida para o tratamento de infecções virais - Google Patents

compostos de tiazolida para o tratamento de infecções virais

Info

Publication number
BR112018069974A2
BR112018069974A2 BR112018069974A BR112018069974A BR112018069974A2 BR 112018069974 A2 BR112018069974 A2 BR 112018069974A2 BR 112018069974 A BR112018069974 A BR 112018069974A BR 112018069974 A BR112018069974 A BR 112018069974A BR 112018069974 A2 BR112018069974 A2 BR 112018069974A2
Authority
BR
Brazil
Prior art keywords
treatment
viral infections
thiazolide compounds
thiazolide
compounds
Prior art date
Application number
BR112018069974A
Other languages
English (en)
Inventor
Rossignol Jean-Francois
Gabriella Santoro Maria
Original Assignee
Romark Laboratories Lc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Romark Laboratories Lc filed Critical Romark Laboratories Lc
Publication of BR112018069974A2 publication Critical patent/BR112018069974A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

compostos de tiazolida, tais como nitazoxanida e/ou tizoxanida, podem ser usados contra vírus que pertencem a família picornaviridae ou a família paramyxoviridae.
BR112018069974A 2016-03-31 2017-03-30 compostos de tiazolida para o tratamento de infecções virais BR112018069974A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662316463P 2016-03-31 2016-03-31
PCT/US2017/024976 WO2017173056A1 (en) 2016-03-31 2017-03-30 Thiazolide compounds for treating viral infections

Publications (1)

Publication Number Publication Date
BR112018069974A2 true BR112018069974A2 (pt) 2019-01-29

Family

ID=58530692

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018069974A BR112018069974A2 (pt) 2016-03-31 2017-03-30 compostos de tiazolida para o tratamento de infecções virais

Country Status (26)

Country Link
US (2) US11135202B2 (pt)
EP (2) EP3436074B1 (pt)
JP (2) JP6567781B2 (pt)
KR (3) KR20210035339A (pt)
CN (1) CN108289961A (pt)
AU (2) AU2017244145B2 (pt)
BR (1) BR112018069974A2 (pt)
CA (2) CA3113354A1 (pt)
CY (1) CY1123221T1 (pt)
DK (1) DK3436074T3 (pt)
EA (2) EA036505B1 (pt)
ES (1) ES2810303T3 (pt)
HK (1) HK1250945A1 (pt)
HR (1) HRP20201261T1 (pt)
HU (1) HUE050601T2 (pt)
IL (2) IL262018A (pt)
LT (1) LT3436074T (pt)
MX (1) MX2021004464A (pt)
PH (1) PH12018502058A1 (pt)
PL (1) PL3436074T3 (pt)
PT (1) PT3436074T (pt)
SG (1) SG11201808453UA (pt)
SI (1) SI3436074T1 (pt)
UA (1) UA126114C2 (pt)
WO (1) WO2017173056A1 (pt)
ZA (1) ZA201806644B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111012778B (zh) * 2018-10-10 2022-06-24 北京市农林科学院 Nitazoxanide在抑制犬细小病毒中的应用
CN109536460A (zh) * 2018-12-07 2019-03-29 中国医学科学院医学生物学研究所 一种cv-a10病毒毒种及其人用灭活疫苗
CN110787161B (zh) * 2019-09-19 2022-09-27 中山大学 噻唑类化合物用于抗鱼类病毒的新用途
CN111012788B (zh) * 2019-12-12 2021-01-15 武汉职业技术学院 硝唑尼特和替唑尼特在制备抗猪繁殖与呼吸综合征病毒药物中的应用
JP2023537237A (ja) 2020-07-20 2023-08-31 ロマーク ラボラトリーズ，リミティド カンパニー チゾキサニドおよび２－ヒドロキシ－ｎ－（５－クロロ－１，３－チアゾル－２－イル）ベンズアミド（ｒｍ－４８４８）とエタノールアミン、モルホリン、プロパノールアミン、ピペラジン、およびｎ－メチルピペラジンの結晶塩
EP4199923A1 (en) 2020-08-24 2023-06-28 Romark Laboratories, L.C. Use of thiazolides against coronaviruses
EP4337200A1 (en) * 2021-05-28 2024-03-20 Henderson, Theodore Treatment using an antiviral compound and nitazoxanide
WO2023040990A1 (zh) 2021-09-15 2023-03-23 南京强新生物医药有限公司 治疗冠状病毒感染的新联用药物、药物组合物及其用途
CN114404439B (zh) * 2022-02-11 2023-07-11 山东农业大学 抑制不同类型猪繁殖与呼吸综合症病毒感染的阻断剂

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1437800A (en) 1973-08-08 1976-06-03 Phavic Sprl Derivatives of 2-benzamido-5-nitro-thiazoles
US5387598A (en) 1994-04-13 1995-02-07 Rossignol; Jean-Francois Composition and galenic formulation suitable for combatting affections of the lower abdomen
US5965590A (en) 1994-09-08 1999-10-12 Romark Lab Lc Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide
US5856348A (en) 1994-09-08 1999-01-05 Romark Laboratories, L.C. Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide
MX9604483A (es) 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
US5859038A (en) 1994-09-08 1999-01-12 Romark Laboratories, L.C. Method for treatment of helicobacter pylori infections
US5968961A (en) 1997-05-07 1999-10-19 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
US5935591A (en) 1998-01-15 1999-08-10 Romark Laboratories, L.C. Method for treatment of equine protozoal myeloencephalitis with thiazolides
US7582297B2 (en) 2003-04-11 2009-09-01 Medimmune, Llc Methods of treating respiratory conditions
UA90864C2 (en) 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
US20060194853A1 (en) 2004-10-08 2006-08-31 Rossignol Jean F Alkyl benzamides
BRPI0706379A2 (pt) 2006-01-09 2011-03-22 Romark Lab Lc tratamento de hepatite viral
BRPI0815057B8 (pt) 2007-08-03 2021-05-25 Romark Laboratories Lc composto, composição farmacêutica, e, uso de um composto
GB0716292D0 (en) * 2007-08-21 2007-09-26 Biofocus Dpi Ltd Imidazopyrazine compounds
PL2395840T3 (pl) 2009-02-13 2020-09-07 Romark Laboratories, L.C. Preparaty farmaceutyczne nitazoksanidu o kontrolowanym uwalnianiu
SG10201402281WA (en) 2009-05-12 2014-07-30 Romark Lab Lc Haloalkyl heteroaryl benzamide compounds
CN108042535A (zh) * 2009-06-26 2018-05-18 罗马克实验室有限公司 用于治疗流感的化合物和方法
EP2585067B1 (en) * 2010-06-25 2017-08-09 Biota Scientific Management Pty Ltd Compound for the treatment of enteroviruses
JP5837936B2 (ja) 2010-11-01 2015-12-24 ロマーク ラボラトリース，エル．シー． アルキルスルフィニル置換チアゾリド化合物
EA024063B1 (ru) 2011-05-16 2016-08-31 Ромарк Лабораториз Л.С. Способ стимуляции иммунного ответа путем введения тиазолидных соединений
JP5904270B2 (ja) 2012-03-15 2016-04-13 トヨタ自動車株式会社 車両走行制御装置
WO2015054465A1 (en) * 2013-10-11 2015-04-16 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2016044656A1 (en) * 2014-09-17 2016-03-24 Ansun Biopharma, Inc. Treatment of infection by human enterovirus d68
US10100023B2 (en) 2014-11-11 2018-10-16 Romark Laboratories, L.C. Compositions and methods of treatment with prodrugs of tizoxanide, an analogue or salt thereof

Also Published As

Publication number Publication date
JP6567781B2 (ja) 2019-08-28
KR20210035339A (ko) 2021-03-31
US11135202B2 (en) 2021-10-05
DK3436074T3 (da) 2020-08-03
EA201891975A1 (ru) 2019-03-29
LT3436074T (lt) 2020-09-25
UA126114C2 (uk) 2022-08-17
US20220125767A1 (en) 2022-04-28
ES2810303T3 (es) 2021-03-08
EP3677282A1 (en) 2020-07-08
CA3113354A1 (en) 2017-10-05
WO2017173056A1 (en) 2017-10-05
KR20180125552A (ko) 2018-11-23
US20170281603A1 (en) 2017-10-05
IL280327A (en) 2021-03-01
JP2019203014A (ja) 2019-11-28
KR20180124970A (ko) 2018-11-21
CY1123221T1 (el) 2021-10-29
HRP20201261T1 (hr) 2021-02-05
EP3436074B1 (en) 2020-06-10
IL262018A (en) 2018-10-31
AU2017244145B2 (en) 2019-08-01
AU2019236602A1 (en) 2019-10-17
EP3436074A1 (en) 2019-02-06
PH12018502058A1 (en) 2019-06-24
EA036505B1 (ru) 2020-11-18
PT3436074T (pt) 2020-08-21
PL3436074T3 (pl) 2020-11-02
KR102136803B1 (ko) 2020-07-22
HK1250945A1 (zh) 2019-01-18
MX2021004464A (es) 2021-06-04
ZA201806644B (en) 2021-02-24
SG11201808453UA (en) 2018-10-30
HUE050601T2 (hu) 2020-12-28
KR102233826B1 (ko) 2021-03-31
EA202091849A1 (ru) 2020-12-11
CA3019326A1 (en) 2017-10-05
CN108289961A (zh) 2018-07-17
AU2017244145A1 (en) 2018-11-15
CA3019326C (en) 2021-05-25
JP2019510044A (ja) 2019-04-11
SI3436074T1 (sl) 2020-09-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2631 DE 08/06/2021 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements