EA201170915A1 - Фосфорамидатные производные гуанозиновых нуклеозидов для лечения вирусных инфекций - Google Patents
Фосфорамидатные производные гуанозиновых нуклеозидов для лечения вирусных инфекцийInfo
- Publication number
- EA201170915A1 EA201170915A1 EA201170915A EA201170915A EA201170915A1 EA 201170915 A1 EA201170915 A1 EA 201170915A1 EA 201170915 A EA201170915 A EA 201170915A EA 201170915 A EA201170915 A EA 201170915A EA 201170915 A1 EA201170915 A1 EA 201170915A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- viral infections
- compounds
- guanosine nucleoside
- phosphoramidate derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Abstract
Предложены фосфорамидатные соединения, производные гуаниновых оснований, обладающие повышенной терапевтической эффективностью, данные соединения, в частности, обладают повышенной эффективностью в лечении вирусных инфекций, таких как инфекция, вызываемая вирусом гепатита С. Также предложены фармацевтические композиции, способы получения указанных соединений и способы применения данных соединений и композиций в лечении вирусных инфекций.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14352709P | 2009-01-09 | 2009-01-09 | |
US18542609P | 2009-06-09 | 2009-06-09 | |
PCT/US2010/020632 WO2010081082A2 (en) | 2009-01-09 | 2010-01-11 | Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201170915A1 true EA201170915A1 (ru) | 2012-02-28 |
Family
ID=42317191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201170915A EA201170915A1 (ru) | 2009-01-09 | 2010-01-11 | Фосфорамидатные производные гуанозиновых нуклеозидов для лечения вирусных инфекций |
Country Status (16)
Country | Link |
---|---|
US (1) | US8759318B2 (ru) |
EP (1) | EP2385951A4 (ru) |
JP (1) | JP2012514657A (ru) |
KR (1) | KR20110120886A (ru) |
CN (1) | CN102348712A (ru) |
AU (1) | AU2010203416C1 (ru) |
BR (1) | BRPI1004575A2 (ru) |
CA (1) | CA2749394A1 (ru) |
EA (1) | EA201170915A1 (ru) |
EC (1) | ECSP11011249A (ru) |
IL (1) | IL213964A0 (ru) |
MX (1) | MX2011007364A (ru) |
PE (1) | PE20120013A1 (ru) |
SG (1) | SG172921A1 (ru) |
WO (1) | WO2010081082A2 (ru) |
ZA (1) | ZA201104978B (ru) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2748034A1 (en) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Purified 2'-deoxy'2'-fluoro-2'-c-methyl-nucleoside-phosphoramidate prodrugs for the treatment of viral infections |
CN102325783A (zh) | 2008-12-23 | 2012-01-18 | 法莫赛特股份有限公司 | 嘌呤核苷的合成 |
PA8855601A1 (es) | 2008-12-23 | 2010-07-27 | Forformidatos de nucleósidos | |
TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
SG184323A1 (en) * | 2010-03-31 | 2012-11-29 | Gilead Pharmasett Llc | Stereoselective synthesis of phosphorus containing actives |
KR20130110170A (ko) * | 2010-09-22 | 2013-10-08 | 앨리오스 바이오파마 인크. | 치환된 뉴클레오타이드 유사체 |
CA2812962C (en) | 2010-09-22 | 2020-03-31 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
WO2012048013A2 (en) * | 2010-10-06 | 2012-04-12 | Inhibitex, Inc. | Phosphorodiamidate derivatives of guanosine nucleoside compounds for treatment of viral injections |
WO2012092484A2 (en) | 2010-12-29 | 2012-07-05 | Inhibitex, Inc. | Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections |
US9095599B2 (en) | 2011-01-03 | 2015-08-04 | Nanjing Molecular Research, Inc. | O-(substituted benzyl) phosphoramidate compounds and therapeutic use |
CN103987712B (zh) * | 2011-07-19 | 2016-05-04 | 河南美泰宝生物制药有限公司 | 2’,3’-二脱氧-2’-α-氟-2’-β-C-甲基核苷和其前药 |
AR088441A1 (es) * | 2011-09-12 | 2014-06-11 | Idenix Pharmaceuticals Inc | Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales |
MX354958B (es) | 2011-09-16 | 2018-03-27 | Gilead Pharmasset Llc | Metodos para el tratamiento de vhc. |
DE202012012956U1 (de) | 2011-10-21 | 2014-10-16 | Abbvie Inc. | Kombination aus mindestens zwei direkt wirkenden antiviralen Wirkstoffen für die Verwendung zur Behandlung von HCV, umfassend Ribavirin aber nicht Interferon |
UY34401A (es) * | 2011-10-21 | 2013-05-31 | Abbvie Inc | Métodos para el tratamiento de hcv |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
WO2013066991A1 (en) * | 2011-10-31 | 2013-05-10 | Inhibitex, Inc. | Crystalline solvates of nucleoside phosphoroamidates, their stereoselective preparation, novel intermediates thereof, and their use in the treatment of viral disease |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
SI2794628T1 (sl) * | 2011-12-20 | 2017-07-31 | Riboscience Llc | 4'-azido-3'-fluoro substituirani nukleozidni derivati kot inhibitorji podvojevanja RNA HCV |
US9296778B2 (en) | 2012-05-22 | 2016-03-29 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphate prodrugs for HCV infection |
PE20150132A1 (es) * | 2012-05-22 | 2015-02-14 | Idenix Pharmaceuticals Inc | Compuestos d-aminoacidos para enfermedad hepatica |
WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
CA2871547C (en) | 2012-05-25 | 2021-05-25 | Janssen R&D Ireland | Uracyl spirooxetane nucleosides |
US20150126752A1 (en) | 2012-06-13 | 2015-05-07 | Bristol-Myers Squibb Company | Process for the preparation of 2-c-methyl-d-ribonic-gamma-lactone |
EP2870169A1 (en) | 2012-07-03 | 2015-05-13 | Bristol-Myers Squibb Company | Process for preparing diastereomerically enriched phosphoramidate derivatives of nucleoside compounds for treatment of viral infections |
CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
WO2014047117A1 (en) | 2012-09-18 | 2014-03-27 | Bristol-Myers Squibb Company | Process for preparing phosphoramidate derivatives of nucleoside compounds for treatment of viral infections |
WO2014052638A1 (en) | 2012-09-27 | 2014-04-03 | Idenix Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
AP2015008384A0 (en) | 2012-10-08 | 2015-04-30 | Univ Montpellier Ct Nat De La Rech Scient | 2'-Chloro nucleoside analogs for hcv infection |
WO2014066239A1 (en) | 2012-10-22 | 2014-05-01 | Idenix Pharmaceuticals, Inc. | 2',4'-bridged nucleosides for hcv infection |
HUE044605T2 (hu) * | 2012-11-16 | 2019-11-28 | Univ College Cardiff Consultants Ltd | RP/SP gemcitabin-[fenil-(benziloxi-L-alaninil)]-foszfát keveréke |
US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
PL2950786T3 (pl) | 2013-01-31 | 2020-05-18 | Gilead Pharmasset Llc | Formulacja skojarzona dwóch związków przeciwwirusowych |
US9309275B2 (en) | 2013-03-04 | 2016-04-12 | Idenix Pharmaceuticals Llc | 3′-deoxy nucleosides for the treatment of HCV |
WO2014137930A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | Thiophosphate nucleosides for the treatment of hcv |
WO2014160484A1 (en) | 2013-03-13 | 2014-10-02 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
WO2014165542A1 (en) | 2013-04-01 | 2014-10-09 | Idenix Pharmaceuticals, Inc. | 2',4'-fluoro nucleosides for the treatment of hcv |
AU2014250764A1 (en) | 2013-04-12 | 2015-10-29 | Achillion Pharmaceuticals, Inc. | Deuterated nucleoside prodrugs useful for treating HCV |
EP3004130B1 (en) | 2013-06-05 | 2019-08-07 | Idenix Pharmaceuticals LLC. | 1',4'-thio nucleosides for the treatment of hcv |
WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
CN103804446A (zh) * | 2014-02-27 | 2014-05-21 | 苏州东南药业股份有限公司 | 一种3,5-二苯甲酰基-2-去氧-2-氟-2甲基-D-核糖-γ-内酯的制备方法 |
WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
MX2021001140A (es) | 2014-06-25 | 2022-04-21 | Nucana Biomed Ltd | Profármacos de gemcitabina. |
CN105348342B (zh) * | 2014-09-30 | 2018-09-21 | 南京正大天晴制药有限公司 | 核苷氨基磷酸酯化合物及药物组合物和用途 |
MX2020010375A (es) | 2014-11-28 | 2022-07-19 | NuCana plc | Nuevos derivados de ester fosforamidato 3'-desoxiadenosina de 2' y/o 5' aminoacido como compuestos anti-cancer. |
UA124966C2 (uk) | 2015-03-06 | 2021-12-22 | Атеа Фармасеутікалс, Інк. | <font face="Symbol">b</font>-D-2'-ДЕЗОКСИ-2'-<font face="Symbol">a</font>-ФТОР-2'-<font face="Symbol">b</font>-C-ЗАМІЩЕНІ-2-МОДИФІКОВАНІ-N<sup>6</sup>-ЗАМІЩЕНІ ПУРИНОВІ НУКЛЕОТИДИ ДЛЯ ЛІКУВАННЯ ВИКЛИКАНИХ HCV ЗАХВОРЮВАНЬ |
CN106279322B (zh) * | 2015-05-15 | 2019-07-30 | 上海唐润医药科技有限公司 | 抗丙肝病毒的核苷类化合物及其应用 |
WO2017079681A1 (en) | 2015-11-05 | 2017-05-11 | The Texas A&M University System | Targeting of ligand binding sites in clfa |
GB201522764D0 (en) * | 2015-12-23 | 2016-02-03 | Nucana Biomed Ltd | Formulations of phosphate derivatives |
WO2017189978A1 (en) | 2016-04-28 | 2017-11-02 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
GB201609601D0 (en) | 2016-06-01 | 2016-07-13 | Nucana Biomed Ltd | Phosphoramidate compounds |
US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
WO2018013937A1 (en) | 2016-07-14 | 2018-01-18 | Atea Pharmaceuticals, Inc. | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
AU2017324939B2 (en) | 2016-09-07 | 2021-10-14 | Atea Pharmaceuticals, Inc. | 2'-substituted-N6-substituted purine nucleotides for RNA virus treatment |
IL295609B2 (en) | 2017-02-01 | 2023-11-01 | Atea Pharmaceuticals Inc | Nucleotide hemisulfate salt for the treatment of hepatitis C virus |
GB201709471D0 (en) | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
US11279728B2 (en) | 2017-08-22 | 2022-03-22 | Albert Einstein College Of Medicine | Broad spectrum viral inhibitor |
GB201715011D0 (en) | 2017-09-18 | 2017-11-01 | Nucana Biomed Ltd | Floxuridine synthesis |
WO2019200005A1 (en) | 2018-04-10 | 2019-10-17 | Atea Pharmaceuticals, Inc. | Treatment of hcv infected patients with cirrhosis |
CN110031583B (zh) * | 2018-12-29 | 2022-01-18 | 浙江工业大学 | 分离测定n-琥珀酰色氨酸对映异构体的液相色谱方法 |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
WO2021173713A1 (en) | 2020-02-27 | 2021-09-02 | Atea Pharmaceuticals, Inc. | Highly active compounds against covid-19 |
CN112778388B (zh) * | 2021-01-21 | 2022-08-23 | 大连医科大学 | 一种核苷类似物及其制备方法和应用 |
WO2022166581A1 (zh) * | 2021-02-07 | 2022-08-11 | 石家庄迪斯凯威医药科技有限公司 | 一种核苷酸衍生物及其药物组合物和用途 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4267233B2 (ja) | 1999-09-10 | 2009-05-27 | ジェロン・コーポレーション | オリゴヌクレオチドn3’→p5’チオホスホルアミデート:それらの合成および使用 |
CA2363274A1 (en) | 1999-12-27 | 2001-07-05 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs for hepatitis c |
AU2001227965A1 (en) * | 2000-01-21 | 2001-07-31 | Geron Corporation | 2'-arabino-fluorooligonucleotide n3'-p5'phosphoramidates: their synthesis and use |
MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
CN1315862C (zh) | 2000-05-26 | 2007-05-16 | 艾登尼科斯(开曼)有限公司 | 处理黄病毒和瘟病毒的方法和组合物 |
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
AU2002317087A1 (en) * | 2001-06-29 | 2003-03-03 | Micrologix Biotech Inc. | Phosphoramide containing nucleic acid-based compounds and libraries as antivirals |
US6841566B2 (en) | 2001-07-20 | 2005-01-11 | Boehringer Ingelheim, Ltd. | Viral polymerase inhibitors |
EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
AP2005003211A0 (en) | 2002-06-28 | 2005-03-31 | Idenix Cayman Ltd | 1'-,2'-and 3'-modified nucleoside derivatives for treating flaviviridae infections. |
WO2004058792A1 (en) | 2002-12-23 | 2004-07-15 | Idenix (Cayman) Limited | Process for the production of 3'-nucleoside prodrugs |
MXPA05008736A (es) * | 2003-02-19 | 2005-10-05 | Univ Yale | Analogos de nucleosido antivirales y metodos para tratar infecciones virales, especialmente infecciones por vih. |
PT1719773E (pt) | 2004-02-24 | 2009-06-03 | Japan Tobacco Inc | Compostos heterotetracíclicos fundidos e a sua utilização como inibidores da polimerase do hcv |
GB0413087D0 (en) | 2004-06-11 | 2004-07-14 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US20070265222A1 (en) | 2004-06-24 | 2007-11-15 | Maccoss Malcolm | Nucleoside Aryl Phosphoramidates for the Treatment of Rna-Dependent Rna Viral Infection |
MX2007004979A (es) | 2004-10-26 | 2007-06-14 | Angeletti P Ist Richerche Bio | Derivados de indol tetraciclicos como agentes antiviricos. |
GB0505781D0 (en) | 2005-03-21 | 2005-04-27 | Univ Cardiff | Chemical compounds |
WO2006121820A1 (en) * | 2005-05-05 | 2006-11-16 | Valeant Research & Development | Phosphoramidate prodrugs for treatment of viral infection |
GB0623493D0 (en) * | 2006-11-24 | 2007-01-03 | Univ Cardiff | Chemical compounds |
US20080261913A1 (en) * | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
-
2010
- 2010-01-11 EA EA201170915A patent/EA201170915A1/ru unknown
- 2010-01-11 AU AU2010203416A patent/AU2010203416C1/en not_active Ceased
- 2010-01-11 MX MX2011007364A patent/MX2011007364A/es active IP Right Grant
- 2010-01-11 JP JP2011545488A patent/JP2012514657A/ja active Pending
- 2010-01-11 EP EP10729622.0A patent/EP2385951A4/en not_active Withdrawn
- 2010-01-11 BR BRPI1004575A patent/BRPI1004575A2/pt not_active IP Right Cessation
- 2010-01-11 SG SG2011050044A patent/SG172921A1/en unknown
- 2010-01-11 KR KR1020117018486A patent/KR20110120886A/ko not_active Application Discontinuation
- 2010-01-11 PE PE2011001334A patent/PE20120013A1/es not_active Application Discontinuation
- 2010-01-11 CA CA2749394A patent/CA2749394A1/en not_active Abandoned
- 2010-01-11 WO PCT/US2010/020632 patent/WO2010081082A2/en active Application Filing
- 2010-01-11 US US13/143,098 patent/US8759318B2/en not_active Expired - Fee Related
- 2010-01-11 CN CN2010800115240A patent/CN102348712A/zh active Pending
-
2011
- 2011-07-06 IL IL213964A patent/IL213964A0/en unknown
- 2011-07-07 ZA ZA2011/04978A patent/ZA201104978B/en unknown
- 2011-08-09 EC EC2011011249A patent/ECSP11011249A/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2010203416A1 (en) | 2011-07-28 |
CA2749394A1 (en) | 2010-07-15 |
SG172921A1 (en) | 2011-08-29 |
AU2010203416C1 (en) | 2013-07-25 |
ZA201104978B (en) | 2012-03-28 |
PE20120013A1 (es) | 2012-02-02 |
CN102348712A (zh) | 2012-02-08 |
WO2010081082A2 (en) | 2010-07-15 |
AU2010203416B2 (en) | 2013-01-31 |
JP2012514657A (ja) | 2012-06-28 |
US8759318B2 (en) | 2014-06-24 |
EP2385951A2 (en) | 2011-11-16 |
US20120052046A1 (en) | 2012-03-01 |
IL213964A0 (en) | 2011-08-31 |
EP2385951A4 (en) | 2013-05-29 |
KR20110120886A (ko) | 2011-11-04 |
ECSP11011249A (es) | 2012-01-31 |
WO2010081082A3 (en) | 2010-11-25 |
BRPI1004575A2 (pt) | 2016-04-05 |
MX2011007364A (es) | 2012-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201170915A1 (ru) | Фосфорамидатные производные гуанозиновых нуклеозидов для лечения вирусных инфекций | |
CY1123324T1 (el) | Παραγωγα πυριμιδινης για τη θεραπευτικη αντιμετωπιση ιογενων λοιμωξεων | |
EA201391519A1 (ru) | 2'-замещенные нуклеозидные производные и способы их применения для лечения вирусных заболеваний | |
CY1119056T1 (el) | Παραγωγα 2',4',-διφθορο-2'-μεθυλ υποκατεστημενου νουκλεοσιδιου ως αναστολεις αντιγραφης hcv rna | |
EA202090258A3 (ru) | Производные пирроло[3,2-d]пиримидина для лечения вирусных инфекций и других заболеваний | |
EA201991767A1 (ru) | Производные пурина для лечения вирусных инфекций | |
EA201290993A1 (ru) | Нуклеозидфосфорамидаты | |
EA201791515A1 (ru) | Соединения пиразина для лечения инфекционных заболеваний | |
EA200901241A1 (ru) | Соединения для лечения гепатита с | |
EA202090662A3 (ru) | ПРОИЗВОДНЫЕ ПИРРОЛО[3,2-d]ПИРИМИДИНА ДЛЯ ЛЕЧЕНИЯ ВИРУСНЫХ ИНФЕКЦИЙ И ДРУГИХ ЗАБОЛЕВАНИЙ | |
EA201590343A1 (ru) | Алкилпиримидиновые производные для лечения вирусных инфекций и дальнейших заболеваний | |
EA201290131A1 (ru) | Производные пурина или деазапурина для применения при лечении вирусных инфекций и других заболеваний | |
EA201290575A1 (ru) | Ингибиторы вирусов flaviviridae | |
EA201401281A1 (ru) | D-аминокислотные химические соединения для лечения заболеваний печени | |
EA201492205A1 (ru) | Макроциклические ингибиторы вирусов flaviviridae | |
EA201391719A1 (ru) | Хиназолиновые производные для лечения вирусных инфекций и дальнейших заболеваний | |
EA201492209A1 (ru) | Макроциклические ингибиторы вирусов flaviviridae | |
EA201290576A1 (ru) | Ингибиторы вирусов flaviviridae | |
EA201390822A1 (ru) | Макроциклические ингибиторы вирусов flaviviridae | |
EA201490588A1 (ru) | Способы лечения вируса гепатита с | |
EA201491180A1 (ru) | 4'-азидо,3'-фторзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк вируса гепатита с | |
EA201590667A1 (ru) | Ациламинопиримидиновые производные для лечения вирусных инфекций и других заболеваний | |
EA201290053A1 (ru) | Ингибиторы вирусов flaviviridae | |
EA201500383A1 (ru) | Производные 1,2,4-триазина для лечения вирусных инфекций | |
WO2009123776A3 (en) | Antiviral drugs for treatment of arenavirus infection |