ECSP11011249A - Derivados de fosforamidato de compuestos nucleósidos de guanosina para el tratamiento de infecciones virales - Google Patents
Derivados de fosforamidato de compuestos nucleósidos de guanosina para el tratamiento de infecciones viralesInfo
- Publication number
- ECSP11011249A ECSP11011249A EC2011011249A ECSP11011249A ECSP11011249A EC SP11011249 A ECSP11011249 A EC SP11011249A EC 2011011249 A EC2011011249 A EC 2011011249A EC SP11011249 A ECSP11011249 A EC SP11011249A EC SP11011249 A ECSP11011249 A EC SP11011249A
- Authority
- EC
- Ecuador
- Prior art keywords
- viral infections
- treatment
- composite
- guanosine nucleoside
- phosphoramidate derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Abstract
Se proporcionan compuestos de fosforamidato derivados de bases de guanina que tienen potencia terapéutica mejorada, y estos compuestos en particular, tienen mayor potencia con respecto al tratamiento de las infecciones virales, como el virus de la hepatitis C. Asimismo, se proporcionan composiciones farmacéuticas, métodos de preparación de los compuestos, y métodos de uso de los compuestos y composiciones para tratar infecciones virales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14352709P | 2009-01-09 | 2009-01-09 | |
US18542609P | 2009-06-09 | 2009-06-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP11011249A true ECSP11011249A (es) | 2012-01-31 |
Family
ID=42317191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2011011249A ECSP11011249A (es) | 2009-01-09 | 2011-08-09 | Derivados de fosforamidato de compuestos nucleósidos de guanosina para el tratamiento de infecciones virales |
Country Status (16)
Country | Link |
---|---|
US (1) | US8759318B2 (es) |
EP (1) | EP2385951A4 (es) |
JP (1) | JP2012514657A (es) |
KR (1) | KR20110120886A (es) |
CN (1) | CN102348712A (es) |
AU (1) | AU2010203416C1 (es) |
BR (1) | BRPI1004575A2 (es) |
CA (1) | CA2749394A1 (es) |
EA (1) | EA201170915A1 (es) |
EC (1) | ECSP11011249A (es) |
IL (1) | IL213964A0 (es) |
MX (1) | MX2011007364A (es) |
PE (1) | PE20120013A1 (es) |
SG (1) | SG172921A1 (es) |
WO (1) | WO2010081082A2 (es) |
ZA (1) | ZA201104978B (es) |
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CN102325783A (zh) | 2008-12-23 | 2012-01-18 | 法莫赛特股份有限公司 | 嘌呤核苷的合成 |
PA8855601A1 (es) | 2008-12-23 | 2010-07-27 | Forformidatos de nucleósidos | |
TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
SG184323A1 (en) * | 2010-03-31 | 2012-11-29 | Gilead Pharmasett Llc | Stereoselective synthesis of phosphorus containing actives |
KR20130110170A (ko) * | 2010-09-22 | 2013-10-08 | 앨리오스 바이오파마 인크. | 치환된 뉴클레오타이드 유사체 |
CA2812962C (en) | 2010-09-22 | 2020-03-31 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
WO2012048013A2 (en) * | 2010-10-06 | 2012-04-12 | Inhibitex, Inc. | Phosphorodiamidate derivatives of guanosine nucleoside compounds for treatment of viral injections |
WO2012092484A2 (en) | 2010-12-29 | 2012-07-05 | Inhibitex, Inc. | Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections |
US9095599B2 (en) | 2011-01-03 | 2015-08-04 | Nanjing Molecular Research, Inc. | O-(substituted benzyl) phosphoramidate compounds and therapeutic use |
CN103987712B (zh) * | 2011-07-19 | 2016-05-04 | 河南美泰宝生物制药有限公司 | 2’,3’-二脱氧-2’-α-氟-2’-β-C-甲基核苷和其前药 |
AR088441A1 (es) * | 2011-09-12 | 2014-06-11 | Idenix Pharmaceuticals Inc | Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales |
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DE202012012956U1 (de) | 2011-10-21 | 2014-10-16 | Abbvie Inc. | Kombination aus mindestens zwei direkt wirkenden antiviralen Wirkstoffen für die Verwendung zur Behandlung von HCV, umfassend Ribavirin aber nicht Interferon |
UY34401A (es) * | 2011-10-21 | 2013-05-31 | Abbvie Inc | Métodos para el tratamiento de hcv |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
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US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
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PE20150132A1 (es) * | 2012-05-22 | 2015-02-14 | Idenix Pharmaceuticals Inc | Compuestos d-aminoacidos para enfermedad hepatica |
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CA2871547C (en) | 2012-05-25 | 2021-05-25 | Janssen R&D Ireland | Uracyl spirooxetane nucleosides |
US20150126752A1 (en) | 2012-06-13 | 2015-05-07 | Bristol-Myers Squibb Company | Process for the preparation of 2-c-methyl-d-ribonic-gamma-lactone |
EP2870169A1 (en) | 2012-07-03 | 2015-05-13 | Bristol-Myers Squibb Company | Process for preparing diastereomerically enriched phosphoramidate derivatives of nucleoside compounds for treatment of viral infections |
CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
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HUE044605T2 (hu) * | 2012-11-16 | 2019-11-28 | Univ College Cardiff Consultants Ltd | RP/SP gemcitabin-[fenil-(benziloxi-L-alaninil)]-foszfát keveréke |
US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
PL2950786T3 (pl) | 2013-01-31 | 2020-05-18 | Gilead Pharmasset Llc | Formulacja skojarzona dwóch związków przeciwwirusowych |
US9309275B2 (en) | 2013-03-04 | 2016-04-12 | Idenix Pharmaceuticals Llc | 3′-deoxy nucleosides for the treatment of HCV |
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CN106279322B (zh) * | 2015-05-15 | 2019-07-30 | 上海唐润医药科技有限公司 | 抗丙肝病毒的核苷类化合物及其应用 |
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-
2010
- 2010-01-11 EA EA201170915A patent/EA201170915A1/ru unknown
- 2010-01-11 AU AU2010203416A patent/AU2010203416C1/en not_active Ceased
- 2010-01-11 MX MX2011007364A patent/MX2011007364A/es active IP Right Grant
- 2010-01-11 JP JP2011545488A patent/JP2012514657A/ja active Pending
- 2010-01-11 EP EP10729622.0A patent/EP2385951A4/en not_active Withdrawn
- 2010-01-11 BR BRPI1004575A patent/BRPI1004575A2/pt not_active IP Right Cessation
- 2010-01-11 SG SG2011050044A patent/SG172921A1/en unknown
- 2010-01-11 KR KR1020117018486A patent/KR20110120886A/ko not_active Application Discontinuation
- 2010-01-11 PE PE2011001334A patent/PE20120013A1/es not_active Application Discontinuation
- 2010-01-11 CA CA2749394A patent/CA2749394A1/en not_active Abandoned
- 2010-01-11 WO PCT/US2010/020632 patent/WO2010081082A2/en active Application Filing
- 2010-01-11 US US13/143,098 patent/US8759318B2/en not_active Expired - Fee Related
- 2010-01-11 CN CN2010800115240A patent/CN102348712A/zh active Pending
-
2011
- 2011-07-06 IL IL213964A patent/IL213964A0/en unknown
- 2011-07-07 ZA ZA2011/04978A patent/ZA201104978B/en unknown
- 2011-08-09 EC EC2011011249A patent/ECSP11011249A/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2010203416A1 (en) | 2011-07-28 |
CA2749394A1 (en) | 2010-07-15 |
SG172921A1 (en) | 2011-08-29 |
AU2010203416C1 (en) | 2013-07-25 |
ZA201104978B (en) | 2012-03-28 |
PE20120013A1 (es) | 2012-02-02 |
CN102348712A (zh) | 2012-02-08 |
WO2010081082A2 (en) | 2010-07-15 |
AU2010203416B2 (en) | 2013-01-31 |
JP2012514657A (ja) | 2012-06-28 |
US8759318B2 (en) | 2014-06-24 |
EP2385951A2 (en) | 2011-11-16 |
US20120052046A1 (en) | 2012-03-01 |
IL213964A0 (en) | 2011-08-31 |
EP2385951A4 (en) | 2013-05-29 |
KR20110120886A (ko) | 2011-11-04 |
EA201170915A1 (ru) | 2012-02-28 |
WO2010081082A3 (en) | 2010-11-25 |
BRPI1004575A2 (pt) | 2016-04-05 |
MX2011007364A (es) | 2012-02-28 |
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