EA201590215A1 - Макроциклические пурины для лечения вирусных инфекций - Google Patents

Макроциклические пурины для лечения вирусных инфекций

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Publication number
EA201590215A1
EA201590215A1 EA201590215A EA201590215A EA201590215A1 EA 201590215 A1 EA201590215 A1 EA 201590215A1 EA 201590215 A EA201590215 A EA 201590215A EA 201590215 A EA201590215 A EA 201590215A EA 201590215 A1 EA201590215 A1 EA 201590215A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
viral infections
macrocyclic
purines
macrocyclic purines
Prior art date
Application number
EA201590215A
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English (en)
Other versions
EA035790B1 (ru
Inventor
Жан-Франсуа Бонфанти
Жером Мишель Клод Фортэн
Филипп Мюллер
Фредерик Марк Морис Дубле
Пьер Жан-Мари Бернар Рабуассон
Эрик Пьер Александр Арну
Original Assignee
ЯНССЕН Ар ЭНД Ди АЙРЛЭНД
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by ЯНССЕН Ар ЭНД Ди АЙРЛЭНД filed Critical ЯНССЕН Ар ЭНД Ди АЙРЛЭНД
Publication of EA201590215A1 publication Critical patent/EA201590215A1/ru
Publication of EA035790B1 publication Critical patent/EA035790B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems

Abstract

Настоящее изобретение относится к производным макроциклических пуринов, способам их получения, фармацевтическим композициям и их применению при лечении вирусных инфекций.
EA201590215A 2012-07-13 2013-07-12 Макроциклические пурины для лечения вирусных инфекций EA035790B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12176330 2012-07-13
PCT/EP2013/064763 WO2014009509A1 (en) 2012-07-13 2013-07-12 Macrocyclic purines for the treatment of viral infections

Publications (2)

Publication Number Publication Date
EA201590215A1 true EA201590215A1 (ru) 2015-06-30
EA035790B1 EA035790B1 (ru) 2020-08-11

Family

ID=48782357

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590215A EA035790B1 (ru) 2012-07-13 2013-07-12 Макроциклические пурины для лечения вирусных инфекций

Country Status (29)

Country Link
US (2) US10280180B2 (ru)
EP (1) EP2872515B1 (ru)
JP (1) JP6250046B2 (ru)
KR (1) KR102207888B1 (ru)
CN (1) CN104703990B (ru)
AU (1) AU2013288600B2 (ru)
BR (1) BR112015000615B1 (ru)
CA (1) CA2874800C (ru)
CL (1) CL2015000080A1 (ru)
CY (1) CY1117971T1 (ru)
DK (1) DK2872515T3 (ru)
EA (1) EA035790B1 (ru)
ES (1) ES2590508T3 (ru)
HK (1) HK1207062A1 (ru)
HR (1) HRP20161125T1 (ru)
HU (1) HUE030685T2 (ru)
IL (1) IL235990B (ru)
LT (1) LT2872515T (ru)
MX (1) MX360718B (ru)
MY (1) MY167797A (ru)
NZ (1) NZ702364A (ru)
PH (1) PH12015500073A1 (ru)
PL (1) PL2872515T3 (ru)
PT (1) PT2872515T (ru)
SG (1) SG11201408542VA (ru)
SI (1) SI2872515T1 (ru)
UA (1) UA113651C2 (ru)
WO (1) WO2014009509A1 (ru)
ZA (1) ZA201500186B (ru)

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