MX360718B - Purinas macrocíclicas para el tratamiento de infecciones víricas. - Google Patents

Purinas macrocíclicas para el tratamiento de infecciones víricas.

Info

Publication number
MX360718B
MX360718B MX2015000513A MX2015000513A MX360718B MX 360718 B MX360718 B MX 360718B MX 2015000513 A MX2015000513 A MX 2015000513A MX 2015000513 A MX2015000513 A MX 2015000513A MX 360718 B MX360718 B MX 360718B
Authority
MX
Mexico
Prior art keywords
viral infections
treatment
macrocyclic
purines
macrocyclic purines
Prior art date
Application number
MX2015000513A
Other languages
English (en)
Other versions
MX2015000513A (es
Inventor
Jean-François Bonfanti
Jérôme Michel Claude Fortin
Philippe Muller
Frédéric Marc Maurice Doublet
Pierre Jean-Marie Bernard Raboisson
Eric Pierre Alexandre Arnoult
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of MX2015000513A publication Critical patent/MX2015000513A/es
Publication of MX360718B publication Critical patent/MX360718B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención se refiere a derivados de purina macrocíclicos que tienen la formula (I), a procesos para su preparación, a composiciones farmacéuticas y a su uso en el tratamiento de infecciones víricas.
MX2015000513A 2012-07-13 2013-07-12 Purinas macrocíclicas para el tratamiento de infecciones víricas. MX360718B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12176330 2012-07-13
PCT/EP2013/064763 WO2014009509A1 (en) 2012-07-13 2013-07-12 Macrocyclic purines for the treatment of viral infections

Publications (2)

Publication Number Publication Date
MX2015000513A MX2015000513A (es) 2015-05-15
MX360718B true MX360718B (es) 2018-11-13

Family

ID=48782357

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015000513A MX360718B (es) 2012-07-13 2013-07-12 Purinas macrocíclicas para el tratamiento de infecciones víricas.

Country Status (28)

Country Link
US (2) US10280180B2 (es)
EP (1) EP2872515B1 (es)
JP (1) JP6250046B2 (es)
KR (1) KR102207888B1 (es)
CN (1) CN104703990B (es)
AU (1) AU2013288600B2 (es)
BR (1) BR112015000615B1 (es)
CA (1) CA2874800C (es)
CL (1) CL2015000080A1 (es)
CY (1) CY1117971T1 (es)
DK (1) DK2872515T3 (es)
EA (1) EA035790B1 (es)
ES (1) ES2590508T3 (es)
HR (1) HRP20161125T1 (es)
HU (1) HUE030685T2 (es)
IL (1) IL235990B (es)
LT (1) LT2872515T (es)
MX (1) MX360718B (es)
MY (1) MY167797A (es)
NZ (1) NZ702364A (es)
PH (1) PH12015500073A1 (es)
PL (1) PL2872515T3 (es)
PT (1) PT2872515T (es)
SG (1) SG11201408542VA (es)
SI (1) SI2872515T1 (es)
UA (1) UA113651C2 (es)
WO (1) WO2014009509A1 (es)
ZA (1) ZA201500186B (es)

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CN103608335B (zh) 2011-04-08 2018-02-23 爱尔兰詹森科学公司 用于治疗病毒感染的嘧啶衍生物
BR122019020718B1 (pt) 2011-11-09 2021-07-06 Janssen Sciences Ireland Uc Derivados purínicos para o tratamento de infecções virais e composição farmacêutica que os compreende
MX360718B (es) 2012-07-13 2018-11-13 Janssen Sciences Ireland Uc Purinas macrocíclicas para el tratamiento de infecciones víricas.
TR201807076T4 (tr) 2012-10-10 2018-06-21 Janssen Sciences Ireland Uc Viral enfeksiyonların ve diğer hastalıkların tedavisine yönelik pirolo[3,2-d]pirimidin derivatları.
SG11201503042QA (en) 2012-11-16 2015-06-29 Janssen Sciences Ireland Uc Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
EA035174B1 (ru) 2013-02-21 2020-05-12 Янссен Сайенсиз Айрлэнд Юси Производные 2-аминопиримидина в качестве модуляторов толл-подобных рецепторов tlr7 и/или tlr8
HRP20170654T1 (hr) 2013-03-29 2017-06-30 Janssen Sciences Ireland Uc Makrociklički deaza-purinoni za liječenje virusnih infekcija
US9861635B2 (en) 2013-05-06 2018-01-09 Merck Patent Gmbh Macrocycles as kinase inhibitors
DK3004074T3 (da) 2013-05-24 2018-01-29 Janssen Sciences Ireland Uc Pyridonderivater til behandling af virusinfektioner og yderligere sygdomme
HRP20171720T1 (hr) 2013-06-27 2017-12-29 Janssen Sciences Ireland Uc Derivati pirolo [3,2-d] pirimidina za liječenje virusnih infekcija i drugih bolesti
EP3027624B1 (en) 2013-07-30 2018-09-12 Janssen Sciences Ireland UC Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections
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