EA200600069A1 - Низкомолекулярные антагонисты toll-подобных рецепторов (tlr) - Google Patents

Низкомолекулярные антагонисты toll-подобных рецепторов (tlr)

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Publication number
EA200600069A1
EA200600069A1 EA200600069A EA200600069A EA200600069A1 EA 200600069 A1 EA200600069 A1 EA 200600069A1 EA 200600069 A EA200600069 A EA 200600069A EA 200600069 A EA200600069 A EA 200600069A EA 200600069 A1 EA200600069 A1 EA 200600069A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
tlr
toll
low
compounds
Prior art date
Application number
EA200600069A
Other languages
English (en)
Inventor
Грэйсон Б. Липфорд
Александра Форсбах
Чарльз М. Зепп
Original Assignee
Коли Фармасьютикал Гмбх
Коли Фармасьютикал Груп, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Коли Фармасьютикал Гмбх, Коли Фармасьютикал Груп, Инк. filed Critical Коли Фармасьютикал Гмбх
Publication of EA200600069A1 publication Critical patent/EA200600069A1/ru

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/12—Ketones
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4462—Non condensed piperidines, e.g. piperocaine only substituted in position 3
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к способам и композициям, пригодным для модуляции передачи сигнала через Toll-подобные рецепторы. Способы включают в себя приведение экспрессирующей TLR клетки в контакт с низкомолекулярным соединением с основной структурой, содержащей по меньшей мере два кольца. Некоторые соединения представляют собой аминохинолины с первичным амином в положении 4. Большинство соединений и способов пригодны в основном для ингибирования иммуностимуляции, включающей в себя по меньшей мере один из TLR9, TLR8, TLR7 и TLR3. Способы могут найти применение для лечения аутоиммуности, воспаления, аллергии, астмы, отторжения трансплантата, заболевания трансплантат против хозяина, инфекции, сепсиса, злокачественных опухолей и иммунодефицита.
EA200600069A 2003-06-20 2004-06-18 Низкомолекулярные антагонисты toll-подобных рецепторов (tlr) EA200600069A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48058803P 2003-06-20 2003-06-20
US55600704P 2004-03-23 2004-03-23
PCT/US2004/019714 WO2005007672A2 (en) 2003-06-20 2004-06-18 Small molecule toll-like receptor (tlr) antagonists

Publications (1)

Publication Number Publication Date
EA200600069A1 true EA200600069A1 (ru) 2006-08-25

Family

ID=34083269

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600069A EA200600069A1 (ru) 2003-06-20 2004-06-18 Низкомолекулярные антагонисты toll-подобных рецепторов (tlr)

Country Status (11)

Country Link
US (2) US7410975B2 (ru)
EP (1) EP1635846A4 (ru)
JP (1) JP2007524615A (ru)
KR (1) KR20060016817A (ru)
AU (1) AU2004257149A1 (ru)
BR (1) BRPI0411514A (ru)
CA (1) CA2528774A1 (ru)
EA (1) EA200600069A1 (ru)
IL (1) IL172580A0 (ru)
MX (1) MXPA05013922A (ru)
WO (1) WO2005007672A2 (ru)

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