SG11201509520QA - Pyridone derivatives for the treatment of viral infections and further diseases - Google Patents

Pyridone derivatives for the treatment of viral infections and further diseases

Info

Publication number
SG11201509520QA
SG11201509520QA SG11201509520QA SG11201509520QA SG11201509520QA SG 11201509520Q A SG11201509520Q A SG 11201509520QA SG 11201509520Q A SG11201509520Q A SG 11201509520QA SG 11201509520Q A SG11201509520Q A SG 11201509520QA SG 11201509520Q A SG11201509520Q A SG 11201509520QA
Authority
SG
Singapore
Prior art keywords
treatment
viral infections
further diseases
pyridone derivatives
pyridone
Prior art date
Application number
SG11201509520QA
Inventor
Gowan David Craig Mc
Pierre Jean-Marie Bernard Raboisson
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of SG11201509520QA publication Critical patent/SG11201509520QA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG11201509520QA 2013-05-24 2014-05-23 Pyridone derivatives for the treatment of viral infections and further diseases SG11201509520QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13169076 2013-05-24
PCT/EP2014/060603 WO2014187932A1 (en) 2013-05-24 2014-05-23 Pyridone derivatives for the treatment of viral infections and further diseases

Publications (1)

Publication Number Publication Date
SG11201509520QA true SG11201509520QA (en) 2015-12-30

Family

ID=48470811

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201509520QA SG11201509520QA (en) 2013-05-24 2014-05-23 Pyridone derivatives for the treatment of viral infections and further diseases

Country Status (20)

Country Link
US (2) US10377738B2 (en)
EP (1) EP3004074B1 (en)
JP (1) JP6377139B2 (en)
KR (1) KR102280559B1 (en)
CN (1) CN105377833B (en)
AU (1) AU2014270418B2 (en)
BR (1) BR112015028890B1 (en)
CA (1) CA2912338C (en)
CL (1) CL2015003431A1 (en)
DK (1) DK3004074T3 (en)
EA (1) EA034674B1 (en)
ES (1) ES2657283T3 (en)
HK (1) HK1216881A1 (en)
IL (1) IL242317B (en)
MX (1) MX365848B (en)
MY (2) MY188071A (en)
PH (1) PH12015502564A1 (en)
SG (1) SG11201509520QA (en)
UA (1) UA117586C2 (en)
WO (1) WO2014187932A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122017025423B1 (en) 2011-04-08 2021-05-11 Janssen Sciences Ireland Uc pyrimidine derivatives, their use in the treatment of viral infections and pharmaceutical composition comprising them
KR102280559B1 (en) * 2013-05-24 2021-07-22 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 Pyridone derivatives for the treatment of viral infections and further diseases
KR102450287B1 (en) 2016-09-29 2022-09-30 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 Pyrimidine prodrugs for treatment of viral infections and additional diseases
TW201945003A (en) 2018-03-01 2019-12-01 愛爾蘭商健生科學愛爾蘭無限公司 2,4-diaminoquinazoline derivatives and medical uses thereof

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2610889B2 (en) 1987-09-03 1997-05-14 日本臓器製薬株式会社 New crosslinked adenine derivatives
NZ329798A (en) 1996-07-03 1999-04-29 Japan Energy Corp Purine derivatives their tautomers and salts thereof and interferon secretion inducers, antiviral agents and anticancer drugs containing the same
CA2263566C (en) 1996-08-28 2003-09-09 Pfizer Inc. Substituted 6,5-hetero-bicyclic derivatives
WO1998014448A1 (en) 1996-10-04 1998-04-09 Kyorin Pharmaceutical Co., Ltd. Pyrazolopyridylpyridazinone derivatives and process for the preparation thereof
AR012634A1 (en) 1997-05-02 2000-11-08 Sugen Inc QUINAZOLINE BASED COMPOUND, FAMACEUTICAL COMPOSITION THAT UNDERSTANDS IT, METHOD TO SYNTHESIZE IT, ITS USE, METHODS OF MODULATION OF THE DESERINE / TREONIN PROTEIN-KINASE FUNCTION AND IN VITRO METHOD TO IDENTIFY COMPOUNDS THAT MODULATE
US6339089B2 (en) 1997-08-13 2002-01-15 Fujirebio Inc. Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same
AU732361B2 (en) 1997-11-28 2001-04-26 Dainippon Sumitomo Pharma Co., Ltd. Novel heterocyclic compounds
TW572758B (en) 1997-12-22 2004-01-21 Sumitomo Pharma Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
NZ506417A (en) 1998-02-17 2003-05-30 Tularik Inc Anti-viral pyrimidine derivatives
US6110929A (en) 1998-07-28 2000-08-29 3M Innovative Properties Company Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
JP4342007B2 (en) 1998-08-10 2009-10-14 大日本住友製薬株式会社 Quinazoline derivatives
JP4315300B2 (en) 1998-08-10 2009-08-19 大日本住友製薬株式会社 Novel quinazoline derivatives
ATE267175T1 (en) 1998-08-27 2004-06-15 Sumitomo Pharma PYRIMIDINE DERIVATIVES
US6583148B1 (en) 1999-04-08 2003-06-24 Krenitsky Pharmaceuticals, Inc. Neurotrophic substituted pyrimidines
CA2323008C (en) 1999-10-11 2005-07-12 Pfizer Inc. Pharmaceutically active compounds
WO2002088079A2 (en) 2001-05-01 2002-11-07 Bristol-Myers Squibb Company Dual inhibitors of pde 7 and pde 4
AU2002364211A1 (en) 2001-12-21 2003-07-15 Bayer Pharmaceuticals Corporation Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
TW200407143A (en) 2002-05-21 2004-05-16 Bristol Myers Squibb Co Pyrrolotriazinone compounds and their use to treat diseases
US7091232B2 (en) 2002-05-21 2006-08-15 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
JPWO2003104230A1 (en) 2002-06-07 2005-10-06 協和醗酵工業株式会社 Bicyclic pyrimidine derivatives
BR0314761A (en) 2002-09-27 2005-07-26 Sumitomo Pharma Adenine Compound and its Use
US8455458B2 (en) 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
BRPI0411514A (en) 2003-06-20 2006-08-01 Coley Pharm Gmbh small molecule toll-like receptor antagonists
BRPI0414045A (en) * 2003-09-05 2006-10-24 Anadys Pharmaceuticals Inc administration of tlr7 ligands and prodrugs thereof for the treatment of hepatitis C virus infection
EP1728793B1 (en) 2004-03-26 2016-02-03 Sumitomo Dainippon Pharma Co., Ltd. 9-substituted 8-oxoadenine compound
WO2005092892A1 (en) 2004-03-26 2005-10-06 Dainippon Sumitomo Pharma Co., Ltd. 8-oxoadenine compound
WO2007084413A2 (en) 2004-07-14 2007-07-26 Ptc Therapeutics, Inc. Methods for treating hepatitis c
CA2575002C (en) 2004-08-10 2015-01-20 Janssen Pharmaceutica N.V. Hiv inhibiting 1,2,4-triazin-6-one derivatives
EP1812409A1 (en) 2004-11-09 2007-08-01 F. Hoffmann-Roche AG Aminoquinazolines compounds
US7498409B2 (en) 2005-03-24 2009-03-03 Schering Corporation Screening assay for TLR7, TLR8 and TLR9 agonists and antagonists
WO2006117670A1 (en) 2005-05-04 2006-11-09 Pfizer Limited 2-amido-6-amino-8-oxopurine derivatives as toll-like receptor modulators for the treatment of cancer and viral infections, such as hepatitis c
TW200716631A (en) * 2005-05-12 2007-05-01 Tibotec Pharm Ltd Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and methods for the preparation thereof
US7994360B2 (en) 2005-05-16 2011-08-09 Xtl Biopharmaceuticals Ltd. Benzofuran compounds
CA2619919C (en) 2005-09-01 2014-04-01 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
EP1939198A4 (en) 2005-09-22 2012-02-15 Dainippon Sumitomo Pharma Co Novel adenine compound
US20070099941A1 (en) 2005-11-02 2007-05-03 Cytovia, Inc. N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
US20090182140A1 (en) 2005-12-02 2009-07-16 Mitsubishi Tanabe Pharma Corporation Alicyclic Heterocyclic Compound
CA2640672A1 (en) 2006-02-17 2007-08-23 Pfizer Limited 3 -deazapurine derivatives as tlr7 modulators
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
WO2008009077A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
US9487533B2 (en) 2006-12-07 2016-11-08 Genentech, Inc. Phosphoinositide 3-kinase inhibitor compounds and methods of use
CN103224506A (en) 2006-12-20 2013-07-31 P.安杰莱蒂分子生物学研究所 Antiviral indoles
CA2677733A1 (en) 2007-02-07 2008-09-25 The Regents Of The University Of California Conjugates of synthetic tlr agonists and uses therefor
JP2008222557A (en) 2007-03-08 2008-09-25 Kotobuki Seiyaku Kk PYRROLO[3,2-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AS EFFECTIVE COMPONENT
ES2457316T3 (en) 2007-03-19 2014-04-25 Astrazeneca Ab 8-Oxo-adenine 9 compounds substituted as toll-like receptor modulators (TLR7)
AR065784A1 (en) 2007-03-20 2009-07-01 Dainippon Sumitomo Pharma Co DERIVATIVES OF 8-OXO ADENINE, DRUGS THAT CONTAIN THEM AND USES AS THERAPEUTIC AGENTS FOR ALLERGIC, ANTIVIRAL OR ANTIBACTERIAL DISEASES.
US8044056B2 (en) 2007-03-20 2011-10-25 Dainippon Sumitomo Pharma Co., Ltd. Adenine compound
CA2687821C (en) 2007-05-22 2015-04-14 Boehringer Ingelheim International Gmbh Benzimidazolone chymase inhibitors
EA024359B1 (en) 2007-06-29 2016-09-30 Джилид Сайэнс, Инк. Purine derivatives and their use as modulators of toll-like receptor 7
AU2008287421A1 (en) 2007-08-10 2009-02-19 Glaxosmithkline Llc Nitrogen containing bicyclic chemical entities for treating viral infections
CA2696824A1 (en) 2007-08-28 2009-03-12 Irm Llc Compounds and compositions as kinase inhibitors
WO2009030998A1 (en) 2007-09-05 2009-03-12 Coley Pharmaceutical Group, Inc. Pyrimidine compounds as toll-like receptor (tlr) agonists
PE20091236A1 (en) * 2007-11-22 2009-09-16 Astrazeneca Ab PYRIMIDINE DERIVATIVES AS IMMUNOMODULATORS OF TLR7
WO2009080836A2 (en) 2007-12-24 2009-07-02 Tibotec Pharmaceuticals Ltd. Macrocyclic indoles as hepatitis c virus inhibitors
KR20100137449A (en) 2008-02-07 2010-12-30 더 리전트 오브 더 유니버시티 오브 캘리포니아 Treatment of bladder diseases with a tlr7 activator
US8461107B2 (en) 2008-04-28 2013-06-11 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
WO2009157560A1 (en) 2008-06-27 2009-12-30 京セラ株式会社 User interface generation device
US8946239B2 (en) 2008-07-10 2015-02-03 Duquesne University Of The Holy Spirit Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
UY31982A (en) * 2008-07-16 2010-02-26 Boehringer Ingelheim Int DERIVATIVES OF 1,2-DIHYDROPIRIDIN-3-CARBOXAMIDS N-SUBSTITUTED
SG175796A1 (en) 2009-05-21 2011-12-29 Astrazeneca Ab Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases
US8637525B2 (en) 2009-07-31 2014-01-28 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
TWI468402B (en) 2009-07-31 2015-01-11 必治妥美雅史谷比公司 Compounds for the reduction of β-amyloid production
WO2011049988A2 (en) 2009-10-20 2011-04-28 Eiger Biopharmaceuticals, Inc. Indazoles to treat flaviviridae virus infection
EP2491035B1 (en) 2009-10-22 2017-08-30 Gilead Sciences, Inc. Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections
KR101094446B1 (en) 2009-11-19 2011-12-15 한국과학기술연구원 2,4,7-Substituted thieno[3,2-d]pyrimidine compounds as protein kinase inhibitors
JP2013032290A (en) 2009-11-20 2013-02-14 Dainippon Sumitomo Pharma Co Ltd Novel fused pyrimidine derivative
DE102010040233A1 (en) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclic aza heterocycles and their use
WO2012067269A1 (en) 2010-11-19 2012-05-24 Dainippon Sumitomo Pharma Co., Ltd. Aminoalkoxyphenyl compounds and their use in the treatment of disease
WO2012066335A1 (en) 2010-11-19 2012-05-24 Astrazeneca Ab Phenol compounds als toll -like receptor 7 agonists
BR122017025423B1 (en) 2011-04-08 2021-05-11 Janssen Sciences Ireland Uc pyrimidine derivatives, their use in the treatment of viral infections and pharmaceutical composition comprising them
US8916575B2 (en) 2011-05-18 2014-12-23 Janssen R&D Ireland Quinazoline derivatives for the treatment of viral infections and further diseases
BR122019020718B1 (en) 2011-11-09 2021-07-06 Janssen Sciences Ireland Uc PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND THE PHARMACEUTICAL COMPOSITION INCLUDING THEM
EP2812331B1 (en) 2012-02-08 2019-01-02 Janssen Sciences Ireland Unlimited Company Piperidino-pyrimidine derivatives for the treatment of viral infections
PT2841428T (en) 2012-04-24 2018-11-29 Vertex Pharma Dna-pk inhibitors
NZ702364A (en) 2012-07-13 2016-09-30 Janssen Sciences Ireland Uc Macrocyclic purines for the treatment of viral infections
EA029266B1 (en) 2012-08-10 2018-02-28 Янссен Сайенсиз Айрлэнд Юси Alkylpyrimidine derivatives for the treatment of viral infections
EP2712866A1 (en) 2012-10-01 2014-04-02 Centre National de la Recherche Scientifique (CNRS) 1,2,4-triazine derivatives for the treatment of viral infections
BR112015007366A2 (en) 2012-10-05 2017-07-04 Janssen Sciences Ireland Uc acylaminopyrimidine derivatives for the treatment of viral infections and other diseases
JP6293765B2 (en) 2012-10-10 2018-03-14 ヤンセン・サイエンシズ・アイルランド・ユーシー Pyrrolo [3,2-D] pyrimidine derivatives for the treatment of viral infections and other diseases
BR112015011036B1 (en) 2012-11-16 2022-02-01 Janssen Sciences Ireland Uc Heterocyclic Substituted 2-Amino-quinazoline Derivatives, Pharmaceutical Composition
EA035174B1 (en) 2013-02-21 2020-05-12 Янссен Сайенсиз Айрлэнд Юси 2-aminopyrimidine derivatives as modulators of toll-like receptors tlr7 and/or tlr8
SG11201508078XA (en) 2013-03-29 2015-11-27 Janssen Sciences Ireland Uc Macrocyclic deaza-purinones for the treatment of viral infections
KR102280559B1 (en) * 2013-05-24 2021-07-22 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 Pyridone derivatives for the treatment of viral infections and further diseases
JP6401788B2 (en) 2013-07-30 2018-10-10 ヤンセン・サイエンシズ・アイルランド・ユーシー Thieno [3,2-d] pyrimidine derivatives for viral infection treatment
US9701661B2 (en) 2014-07-11 2017-07-11 Northwestern University 2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase

Also Published As

Publication number Publication date
US10865193B2 (en) 2020-12-15
ES2657283T3 (en) 2018-03-02
CN105377833A (en) 2016-03-02
KR20160013060A (en) 2016-02-03
WO2014187932A1 (en) 2014-11-27
JP2016518457A (en) 2016-06-23
EP3004074A1 (en) 2016-04-13
BR112015028890B1 (en) 2022-09-20
BR112015028890A2 (en) 2017-07-25
UA117586C2 (en) 2018-08-27
CA2912338C (en) 2022-01-25
PH12015502564B1 (en) 2016-02-22
HK1216881A1 (en) 2016-12-09
CL2015003431A1 (en) 2016-07-08
DK3004074T3 (en) 2018-01-29
AU2014270418B2 (en) 2017-11-30
KR102280559B1 (en) 2021-07-22
EP3004074B1 (en) 2017-10-25
MY188071A (en) 2021-11-16
NZ713679A (en) 2021-06-25
EA034674B1 (en) 2020-03-05
JP6377139B2 (en) 2018-08-22
IL242317B (en) 2018-05-31
EA201592242A1 (en) 2016-04-29
CA2912338A1 (en) 2014-11-27
MY191923A (en) 2022-07-18
US20190367474A1 (en) 2019-12-05
PH12015502564A1 (en) 2016-02-22
CN105377833B (en) 2018-11-06
US20160108021A1 (en) 2016-04-21
US10377738B2 (en) 2019-08-13
MX365848B (en) 2019-06-17
AU2014270418A1 (en) 2015-11-12

Similar Documents

Publication Publication Date Title
IL264541B (en) Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
HRP20181863T1 (en) Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
HK1207636A1 (en) Alkylpyrimidine derivatives for the treatment of viral infections and further diseases
HK1217330A1 (en) N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b n--
HK1210463A1 (en) Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases
HK1213569A1 (en) 2-aminopyrimidine derivatives for the treatment of viral infections 2-
HK1216881A1 (en) Pyridone derivatives for the treatment of viral infections and further diseases
AP2015008814A0 (en) Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b