MX366481B - Deaza-purinonas macrociclicas para el tratamiento de infecciones virales. - Google Patents
Deaza-purinonas macrociclicas para el tratamiento de infecciones virales.Info
- Publication number
- MX366481B MX366481B MX2015013809A MX2015013809A MX366481B MX 366481 B MX366481 B MX 366481B MX 2015013809 A MX2015013809 A MX 2015013809A MX 2015013809 A MX2015013809 A MX 2015013809A MX 366481 B MX366481 B MX 366481B
- Authority
- MX
- Mexico
- Prior art keywords
- purinones
- viral infections
- treatment
- deaza
- macrocyclic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invención se refiere a derivados de deaza-purinonas macrocíclicas, procesos para su preparación, composiciones farmacéuticas y su uso en el tratamiento de infecciones virales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13161865 | 2013-03-29 | ||
PCT/EP2014/056270 WO2014154859A1 (en) | 2013-03-29 | 2014-03-28 | Macrocyclic deaza-purinones for the treatment of viral infections |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015013809A MX2015013809A (es) | 2016-02-16 |
MX366481B true MX366481B (es) | 2019-07-09 |
Family
ID=48040051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015013809A MX366481B (es) | 2013-03-29 | 2014-03-28 | Deaza-purinonas macrociclicas para el tratamiento de infecciones virales. |
Country Status (22)
Country | Link |
---|---|
US (3) | US10266543B2 (es) |
EP (1) | EP2978429B1 (es) |
JP (2) | JP6336036B2 (es) |
KR (1) | KR102280554B1 (es) |
CN (2) | CN105338983B (es) |
AU (1) | AU2014242954B2 (es) |
BR (1) | BR112015024411B1 (es) |
CA (1) | CA2902837C (es) |
CL (1) | CL2015002891A1 (es) |
DK (1) | DK2978429T3 (es) |
EA (2) | EA202090547A3 (es) |
ES (1) | ES2625456T3 (es) |
HR (1) | HRP20170654T1 (es) |
HU (1) | HUE031908T2 (es) |
IL (1) | IL240765A0 (es) |
MX (1) | MX366481B (es) |
PH (1) | PH12015502261A1 (es) |
PL (1) | PL2978429T3 (es) |
PT (1) | PT2978429T (es) |
SG (1) | SG11201508078XA (es) |
UA (1) | UA115588C2 (es) |
WO (1) | WO2014154859A1 (es) |
Families Citing this family (28)
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PT2694484T (pt) | 2011-04-08 | 2018-11-07 | Janssen Sciences Ireland Uc | Derivados de pirimidina para o tratamento de infeções virais |
EA033830B1 (ru) | 2011-11-09 | 2019-11-29 | Janssen Sciences Ireland Uc | Производные аденина в качестве активаторов толл-подобных рецепторов tlr7 |
PL2872515T3 (pl) | 2012-07-13 | 2017-05-31 | Janssen Sciences Ireland Uc | Puryny makrocykliczne do leczenia infekcji wirusowych |
PL2906563T3 (pl) | 2012-10-10 | 2018-10-31 | Janssen Sciences Ireland Uc | Pochodne pirolo[3,2-d]pirymidyny do leczenia infekcji wirusowych i innych chorób |
BR112015011036B1 (pt) | 2012-11-16 | 2022-02-01 | Janssen Sciences Ireland Uc | Derivados de 2-amino-quinazolina substituídos heterocíclicos, composição farmacêutica |
AU2014220717B2 (en) | 2013-02-21 | 2018-03-29 | Janssen Sciences Ireland Uc | 2-aminopyrimidine derivatives for the treatment of viral infections |
EP2978429B1 (en) | 2013-03-29 | 2017-02-22 | Janssen Sciences Ireland UC | Macrocyclic deaza-purinones for the treatment of viral infections |
SG11201509520QA (en) | 2013-05-24 | 2015-12-30 | Janssen Sciences Ireland Uc | Pyridone derivatives for the treatment of viral infections and further diseases |
EP3030563B1 (en) | 2013-06-27 | 2017-08-09 | Janssen Sciences Ireland UC | Pyrrolo [3,2-d] pyrimidine derivatives for the treatment of viral infections and other diseases |
SG11201510736PA (en) | 2013-07-30 | 2016-02-26 | Janssen Sciences Ireland Uc | THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS |
PL3294740T3 (pl) | 2015-05-08 | 2020-03-31 | F. Hoffmann-La Roche Ag | Nowe sulfonoimidoilopurynony i pochodne do leczenia i profilaktyki infekcji wirusowych |
CN109476675B (zh) | 2016-07-01 | 2022-12-09 | 爱尔兰詹森科学公司 | 用于治疗病毒性感染的二氢吡喃并嘧啶衍生物 |
AU2017335205B2 (en) | 2016-09-29 | 2021-11-04 | Janssen Sciences Ireland Unlimited Company | Pyrimidine prodrugs for the treatment of viral infections and further diseases |
KR102028257B1 (ko) | 2017-11-29 | 2019-10-02 | 강선혜 | 아토피 피부염 개선용 화장료 조성물 및 이를 포함하는 드레싱제 |
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KR20220132591A (ko) | 2020-01-27 | 2022-09-30 | 브리스톨-마이어스 스큅 컴퍼니 | 톨-유사 수용체 7 (TLR7) 효능제로서의 1H-피라졸로[4,3-d]피리미딘 화합물 |
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KR20220132601A (ko) | 2020-01-27 | 2022-09-30 | 브리스톨-마이어스 스큅 컴퍼니 | 톨-유사 수용체 7 (TLR7) 효능제로서의 1H-피라졸로[4,3-d]피리미딘 화합물 |
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