EA202090547A3 - Макроциклические деаза-оксипурины для лечения вирусных инфекций - Google Patents
Макроциклические деаза-оксипурины для лечения вирусных инфекцийInfo
- Publication number
- EA202090547A3 EA202090547A3 EA202090547A EA202090547A EA202090547A3 EA 202090547 A3 EA202090547 A3 EA 202090547A3 EA 202090547 A EA202090547 A EA 202090547A EA 202090547 A EA202090547 A EA 202090547A EA 202090547 A3 EA202090547 A3 EA 202090547A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- dease
- macrocyclic
- treatment
- viral infections
- oxipurins
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Abstract
Настоящее изобретение относится к производным макроциклических деаза-оксипуринов, способам их получения, фармацевтическим композициям и их применению при лечении вирусных инфекций.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13161865 | 2013-03-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA202090547A2 EA202090547A2 (ru) | 2020-09-30 |
EA202090547A3 true EA202090547A3 (ru) | 2020-12-30 |
Family
ID=48040051
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202090547A EA202090547A3 (ru) | 2013-03-29 | 2014-03-28 | Макроциклические деаза-оксипурины для лечения вирусных инфекций |
EA201591887A EA035110B1 (ru) | 2013-03-29 | 2014-03-28 | Макроциклические деаза-оксипурины в качестве модуляторов tlr7 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201591887A EA035110B1 (ru) | 2013-03-29 | 2014-03-28 | Макроциклические деаза-оксипурины в качестве модуляторов tlr7 |
Country Status (22)
Country | Link |
---|---|
US (3) | US10266543B2 (ru) |
EP (1) | EP2978429B1 (ru) |
JP (2) | JP6336036B2 (ru) |
KR (1) | KR102280554B1 (ru) |
CN (2) | CN110590809B (ru) |
AU (1) | AU2014242954B2 (ru) |
BR (1) | BR112015024411B1 (ru) |
CA (1) | CA2902837C (ru) |
CL (1) | CL2015002891A1 (ru) |
DK (1) | DK2978429T3 (ru) |
EA (2) | EA202090547A3 (ru) |
ES (1) | ES2625456T3 (ru) |
HR (1) | HRP20170654T1 (ru) |
HU (1) | HUE031908T2 (ru) |
IL (1) | IL240765A0 (ru) |
MX (1) | MX366481B (ru) |
PH (1) | PH12015502261B1 (ru) |
PL (1) | PL2978429T3 (ru) |
PT (1) | PT2978429T (ru) |
SG (1) | SG11201508078XA (ru) |
UA (1) | UA115588C2 (ru) |
WO (1) | WO2014154859A1 (ru) |
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KR102058946B1 (ko) | 2011-04-08 | 2019-12-24 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 치료를 위한 피리미딘 유도체 |
IN2014MN00862A (ru) | 2011-11-09 | 2015-04-17 | Janssen R & D Ireland | |
UA113651C2 (xx) | 2012-07-13 | 2017-02-27 | Макроциклічні пурини для лікування вірусних інфекцій | |
DK2906563T3 (en) | 2012-10-10 | 2018-06-06 | Janssen Sciences Ireland Uc | PYRROLO [3,2-D] PYRIMIDINE DERIVATIVES FOR TREATING VIRUS INFECTIONS AND OTHER DISEASES |
PL2925729T3 (pl) | 2012-11-16 | 2018-04-30 | Janssen Sciences Ireland Uc | Heterocykliczne podstawione pochodne 2-amino-chinazoliny do leczenia infekcji wirusowych |
BR112015020118B1 (pt) | 2013-02-21 | 2022-02-22 | Janssen Sciences Ireland Uc | Derivados de 2-aminopirimidina para o tratamento de infecções virais, composição farmacêutica e uso |
HUE031908T2 (en) | 2013-03-29 | 2017-08-28 | Janssen Sciences Ireland Uc | Macrocyclic deaza-purinones for the treatment of viral infections |
US10377738B2 (en) | 2013-05-24 | 2019-08-13 | Janssen Sciences Ireland Unlimited Company | Pyridone derivatives for the treatment of viral infections and further diseases |
BR112015032546B1 (pt) | 2013-06-27 | 2022-05-17 | Janssen Sciences Ireland Uc | Derivados de pirrolo[3,2-d]pirimidina e composição farmacêutica que os compreende para o tratamento de infecções virais e outras doenças |
EA036162B1 (ru) | 2013-07-30 | 2020-10-08 | Янссен Сайенсиз Айрлэнд Юси | Производные тиено[3,2-d]пиримидинов для лечения вирусных инфекций |
MY182353A (en) | 2015-05-08 | 2021-01-20 | Hoffmann La Roche | Novel sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection |
MA45539A (fr) | 2016-07-01 | 2019-05-08 | Janssen Sciences Ireland Unlimited Co | Dihydropyranopyrimidines pour le traitement d'infections virales |
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