BR112015024411A2 - desaza-purinonas macrocíclicas para o tratamento de infeções virais - Google Patents

desaza-purinonas macrocíclicas para o tratamento de infeções virais

Info

Publication number
BR112015024411A2
BR112015024411A2 BR112015024411A BR112015024411A BR112015024411A2 BR 112015024411 A2 BR112015024411 A2 BR 112015024411A2 BR 112015024411 A BR112015024411 A BR 112015024411A BR 112015024411 A BR112015024411 A BR 112015024411A BR 112015024411 A2 BR112015024411 A2 BR 112015024411A2
Authority
BR
Brazil
Prior art keywords
desaza
macrocyclic
treatment
viral infections
purinones
Prior art date
Application number
BR112015024411A
Other languages
English (en)
Other versions
BR112015024411B1 (pt
Inventor
Pierre Alexandre Arnoult Eric
Marc Maurice Doublet Frédéric
Bonfanti Jean-François
Michel Claude Fortin Jérôme
Muller Philippe
Jean-Marie Bernard Raboisson Pierre
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of BR112015024411A2 publication Critical patent/BR112015024411A2/pt
Publication of BR112015024411B1 publication Critical patent/BR112015024411B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Abstract

resumo patente de invenção: "desaza-purinonas macrocíclicas para o tratamento de infeções virais". a presente invenção refere-se a derivados de desaza-purinonas macrocíclicas, a processos para a sua preparação, a composições farmacêuticas, e à sua utilização no tratamento de infeções virais.
BR112015024411-4A 2013-03-29 2014-03-28 Desaza-purinonas macrocíclicas para o tratamento de infeções virais e composição farmacêutica que os compreende BR112015024411B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13161865.4 2013-03-29
EP13161865 2013-03-29
PCT/EP2014/056270 WO2014154859A1 (en) 2013-03-29 2014-03-28 Macrocyclic deaza-purinones for the treatment of viral infections

Publications (2)

Publication Number Publication Date
BR112015024411A2 true BR112015024411A2 (pt) 2017-07-18
BR112015024411B1 BR112015024411B1 (pt) 2022-02-22

Family

ID=48040051

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015024411-4A BR112015024411B1 (pt) 2013-03-29 2014-03-28 Desaza-purinonas macrocíclicas para o tratamento de infeções virais e composição farmacêutica que os compreende

Country Status (22)

Country Link
US (3) US10266543B2 (pt)
EP (1) EP2978429B1 (pt)
JP (2) JP6336036B2 (pt)
KR (1) KR102280554B1 (pt)
CN (2) CN110590809B (pt)
AU (1) AU2014242954B2 (pt)
BR (1) BR112015024411B1 (pt)
CA (1) CA2902837C (pt)
CL (1) CL2015002891A1 (pt)
DK (1) DK2978429T3 (pt)
EA (2) EA202090547A3 (pt)
ES (1) ES2625456T3 (pt)
HR (1) HRP20170654T1 (pt)
HU (1) HUE031908T2 (pt)
IL (1) IL240765A0 (pt)
MX (1) MX366481B (pt)
PH (1) PH12015502261B1 (pt)
PL (1) PL2978429T3 (pt)
PT (1) PT2978429T (pt)
SG (1) SG11201508078XA (pt)
UA (1) UA115588C2 (pt)
WO (1) WO2014154859A1 (pt)

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SI2694484T1 (sl) 2011-04-08 2018-10-30 Janssen Sciences Ireland Uc Derivati pirimidina za zdravljenje virusnih okužb
PL2776439T3 (pl) 2011-11-09 2018-12-31 Janssen Sciences Ireland Uc Pochodne puryny do leczenia zakażeń wirusowych
EP2872515B1 (en) 2012-07-13 2016-06-08 Janssen Sciences Ireland UC Macrocyclic purines for the treatment of viral infections
HUE037064T2 (hu) 2012-10-10 2018-08-28 Janssen Sciences Ireland Uc Pirrolo[3,2-d]-pirimidin származékok vírusos fertõzések és egyéb betegségek kezelésére
EP2925729B1 (en) 2012-11-16 2017-10-18 Janssen Sciences Ireland UC Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
DK2958900T3 (da) 2013-02-21 2019-07-01 Janssen Sciences Ireland Unlimited Co 2-aminopyrimidinderivater til behandling af virusinfektioner
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ES2657283T3 (es) 2013-05-24 2018-03-02 Janssen Sciences Ireland Uc Derivados de piridona para el tratamiento de infecciones virales y enfermedades adicionales
UA117590C2 (uk) 2013-06-27 2018-08-27 ЯНССЕН САЙЄНСЕЗ АЙРЛЕНД ЮСі ПОХІДНІ ПІРОЛО[3,2-d]ПІРИМІДИНУ ДЛЯ ЛІКУВАННЯ ВІРУСНИХ ІНФЕКЦІЙ ТА ІНШИХ ЗАХВОРЮВАНЬ
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