ATE267175T1 - Pyrimidin derivate - Google Patents
Pyrimidin derivateInfo
- Publication number
- ATE267175T1 ATE267175T1 AT99938567T AT99938567T ATE267175T1 AT E267175 T1 ATE267175 T1 AT E267175T1 AT 99938567 T AT99938567 T AT 99938567T AT 99938567 T AT99938567 T AT 99938567T AT E267175 T1 ATE267175 T1 AT E267175T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrimidine derivatives
- immunodeficiecy
- syndrome
- aids
- chem
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000978 Interleukin-4 Proteins 0.000 abstract 1
- 108010002616 Interleukin-5 Proteins 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24184298 | 1998-08-27 | ||
| JP25350698 | 1998-09-08 | ||
| PCT/JP1999/004505 WO2000012487A1 (en) | 1998-08-27 | 1999-08-20 | Pyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE267175T1 true ATE267175T1 (de) | 2004-06-15 |
Family
ID=26535473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99938567T ATE267175T1 (de) | 1998-08-27 | 1999-08-20 | Pyrimidin derivate |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6458798B1 (de) |
| EP (1) | EP1110951B1 (de) |
| JP (1) | JP4497340B2 (de) |
| AT (1) | ATE267175T1 (de) |
| CA (1) | CA2341707C (de) |
| DE (1) | DE69917469T2 (de) |
| ES (1) | ES2221414T3 (de) |
| WO (1) | WO2000012487A1 (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7772432B2 (en) | 1991-09-19 | 2010-08-10 | Astrazeneca Ab | Amidobenzamide derivatives which are useful as cytokine inhibitors |
| DK1117653T3 (da) | 1998-10-01 | 2003-05-26 | Astrazeneca Ab | Quinolin- og quinazolinderivater og deres anvendelse som inhibitorer af cykokin-merierede sygdomme |
| NZ514195A (en) | 1999-03-17 | 2004-05-28 | Astrazeneca Ab | Amide derivatives |
| US7037916B2 (en) | 1999-07-15 | 2006-05-02 | Pharmacopeia Drug Discovery, Inc. | Pyrimidine derivatives as IL-8 receptor antagonists |
| GB9924092D0 (en) * | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
| GB0324790D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Amide derivatives |
| TWI392678B (zh) | 2004-03-26 | 2013-04-11 | Dainippon Sumitomo Pharma Co | ９-取代-８-氧基腺嘌呤化合物 |
| WO2006006616A1 (ja) * | 2004-07-13 | 2006-01-19 | Taiho Pharmaceutical Co., Ltd. | トシル酸スプラタスト結晶の均一性の評価方法並びに均一な結晶及びその製造方法 |
| TW200801003A (en) * | 2005-09-16 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
| US8138172B2 (en) | 2006-07-05 | 2012-03-20 | Astrazeneca Ab | 8-oxoadenine derivatives acting as modulators of TLR7 |
| CA2656535C (en) * | 2006-07-14 | 2011-08-23 | Amgen Inc. | Alkyne-substituted pyridone compounds and methods of use |
| TW200831105A (en) | 2006-12-14 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
| EP2139894B1 (de) * | 2007-03-19 | 2011-10-26 | AstraZeneca AB | 9-substituierte 8-oxoadeninverbindungen als modulatoren des toll-like-receptor (tlr7) |
| JP5480637B2 (ja) * | 2007-03-19 | 2014-04-23 | アストラゼネカ・アクチエボラーグ | Ｔｏｌｌ様受容体（ｔｌｒ７）モジュレーターとしての９−置換−８−オキソ−アデニン化合物 |
| US8044056B2 (en) | 2007-03-20 | 2011-10-25 | Dainippon Sumitomo Pharma Co., Ltd. | Adenine compound |
| AR065784A1 (es) * | 2007-03-20 | 2009-07-01 | Dainippon Sumitomo Pharma Co | Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas. |
| AU2008247165B2 (en) | 2007-05-08 | 2011-11-03 | Astrazeneca Ab | Imidazoquinolines with immuno-modulating properties |
| PE20091236A1 (es) * | 2007-11-22 | 2009-09-16 | Astrazeneca Ab | Derivados de pirimidina como immunomoduladores de tlr7 |
| UY31531A1 (es) | 2007-12-17 | 2009-08-03 | Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr) | |
| CA2734486A1 (en) * | 2008-08-20 | 2010-02-25 | Southern Research Institute | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
| WO2010064705A1 (ja) * | 2008-12-05 | 2010-06-10 | 大日本住友製薬株式会社 | Ｈ４受容体アンタゴニスト作用を有する新規７位置換ジヒドロピラノピリミジン誘導体 |
| JP5913093B2 (ja) | 2009-05-21 | 2016-04-27 | アストラゼネカ アクチボラグ | 新規ピリミジン誘導体と、癌とさらなる疾患の治療におけるそれらの使用 |
| GB0908772D0 (en) * | 2009-05-21 | 2009-07-01 | Astrazeneca Ab | New salts 756 |
| EP2507237A1 (de) * | 2009-12-03 | 2012-10-10 | Dainippon Sumitomo Pharma Co., Ltd. | Über toll-like-rezeptoren (tlr) agierende imidazochinoline |
| ES2575688T3 (es) | 2010-12-16 | 2016-06-30 | Sumitomo Dainippon Pharma Co., Ltd. | Derivado de imidazo[4,5-c]quinolin-1-ilo útil en terapia |
| JP5978226B2 (ja) | 2010-12-17 | 2016-08-24 | 大日本住友製薬株式会社 | プリン誘導体 |
| KR101946499B1 (ko) | 2011-04-08 | 2019-02-11 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 치료를 위한 피리미딘 유도체 |
| EP2776439B1 (de) | 2011-11-09 | 2018-07-04 | Janssen Sciences Ireland UC | Purinderivate zur behandlung von virusinfektionen |
| EA039373B1 (ru) * | 2012-02-08 | 2022-01-19 | Янссен Сайенсиз Айрлэнд Юси | Производные пиперидино-пиримидина для лечения вирусных инфекций |
| AU2013261267B2 (en) | 2012-05-18 | 2017-06-29 | Sumitomo Pharma Co., Ltd. | Carboxylic acid compounds |
| CA2874800C (en) | 2012-07-13 | 2021-04-06 | Janssen R&D Ireland | Macrocyclic purines for the treatment of viral infections |
| BR112015002524B1 (pt) * | 2012-08-10 | 2021-11-03 | Janssen Sciences Ireland Uc | Derivados de alquilpirimidina, composição farmacêutica que os compreende e uso dos mesmos |
| KR102198128B1 (ko) | 2012-10-05 | 2021-01-05 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 및 추가 질환의 치료를 위한 아실아미노피리미딘 유도체 |
| NZ705589A (en) | 2012-10-10 | 2019-05-31 | Janssen Sciences Ireland Uc | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases |
| AU2013346793B2 (en) | 2012-11-16 | 2018-03-08 | Janssen Sciences Ireland Uc | Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections |
| KR102225233B1 (ko) | 2013-02-21 | 2021-03-09 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염의 치료를 위한 2-아미노피리미딘 유도체 |
| MX366481B (es) | 2013-03-29 | 2019-07-09 | Janssen Sciences Ireland Uc | Deaza-purinonas macrociclicas para el tratamiento de infecciones virales. |
| MY188071A (en) | 2013-05-24 | 2021-11-16 | Janssen Sciences Ireland Uc | Pyridone derivatives for the treatment of viral infections and further diseases |
| CN109369643B (zh) | 2013-06-27 | 2021-05-18 | 爱尔兰詹森科学公司 | 用于治疗病毒感染和其他疾病的吡咯并[3,2-d]嘧啶衍生物 |
| EP3027624B1 (de) | 2013-07-30 | 2018-09-12 | Janssen Sciences Ireland UC | Thieno[3,2-d]pyrimidin-derivate zur behandlung von virusinfektionen |
| SG11201802832UA (en) | 2015-10-07 | 2018-05-30 | Sumitomo Dainippon Pharma Co Ltd | Pyrimidine compound |
| WO2018002319A1 (en) * | 2016-07-01 | 2018-01-04 | Janssen Sciences Ireland Uc | Dihydropyranopyrimidines for the treatment of viral infections |
| WO2018060317A1 (en) | 2016-09-29 | 2018-04-05 | Janssen Sciences Ireland Uc | Pyrimidine prodrugs for the treatment of viral infections and further diseases |
| US10662161B2 (en) * | 2017-01-30 | 2020-05-26 | Regents Of The University Of Minnesota | Pyrimidines and uses thereof |
| FI3603619T3 (fi) | 2017-03-29 | 2025-09-25 | Sumitomo Pharma Co Ltd | Rokoteadjuvanttiformulaatio |
| AU2018391899A1 (en) | 2017-12-21 | 2020-07-02 | Sumitomo Pharma Co., Ltd. | Combination drug including TLR7 agonist |
| TW202415645A (zh) | 2018-03-01 | 2024-04-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | ２，４－二胺基喹唑啉衍生物及其醫學用途 |
| MX2021000951A (es) | 2018-07-23 | 2021-06-23 | Sumitomo Pharma Co Ltd | Composición que contiene vacuna contra la influenza. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3185691A (en) * | 1965-05-25 | Gycloocteno-pyrimroines | ||
| GB152883A (en) | 1919-11-26 | 1920-10-28 | Carl Conrad Albin Perlich | Improvements in means for controlling the supply of gas to gas cooking apparatus |
| US3034954A (en) * | 1960-03-23 | 1962-05-15 | Monsanto Chemicals | Virus inhibitors |
| DE1470336A1 (de) * | 1962-07-04 | 1969-03-20 | Thomae Gmbh Dr K | Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung |
| GB1152883A (en) * | 1967-01-25 | 1969-05-21 | Ucb Sa | 4,5-Polymethylene-Pyrimidine Derivatives |
| JP2762430B2 (ja) * | 1991-01-18 | 1998-06-04 | 宇部興産株式会社 | アラルキルアミノピリミジン類の製法 |
| CA2230896A1 (en) | 1995-09-01 | 1997-03-13 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
-
1999
- 1999-08-20 AT AT99938567T patent/ATE267175T1/de not_active IP Right Cessation
- 1999-08-20 US US09/763,728 patent/US6458798B1/en not_active Expired - Fee Related
- 1999-08-20 WO PCT/JP1999/004505 patent/WO2000012487A1/ja not_active Ceased
- 1999-08-20 CA CA2341707A patent/CA2341707C/en not_active Expired - Fee Related
- 1999-08-20 DE DE69917469T patent/DE69917469T2/de not_active Expired - Lifetime
- 1999-08-20 ES ES99938567T patent/ES2221414T3/es not_active Expired - Lifetime
- 1999-08-20 EP EP99938567A patent/EP1110951B1/de not_active Expired - Lifetime
- 1999-08-20 JP JP2000567517A patent/JP4497340B2/ja not_active Expired - Fee Related
-
2002
- 2002-08-19 US US10/222,922 patent/US6951866B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69917469T2 (de) | 2005-05-12 |
| US6951866B2 (en) | 2005-10-04 |
| EP1110951A4 (de) | 2002-01-02 |
| US20030105323A1 (en) | 2003-06-05 |
| EP1110951B1 (de) | 2004-05-19 |
| WO2000012487A1 (en) | 2000-03-09 |
| EP1110951A1 (de) | 2001-06-27 |
| ES2221414T3 (es) | 2004-12-16 |
| CA2341707C (en) | 2010-02-16 |
| DE69917469D1 (de) | 2004-06-24 |
| CA2341707A1 (en) | 2000-03-09 |
| JP4497340B2 (ja) | 2010-07-07 |
| US6458798B1 (en) | 2002-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |