BR112015000615A8 - Purinas macrocíclicas para o tratamento de infecções virais e composição farmacêutica que as compreende - Google Patents

Purinas macrocíclicas para o tratamento de infecções virais e composição farmacêutica que as compreende

Info

Publication number
BR112015000615A8
BR112015000615A8 BR112015000615A BR112015000615A BR112015000615A8 BR 112015000615 A8 BR112015000615 A8 BR 112015000615A8 BR 112015000615 A BR112015000615 A BR 112015000615A BR 112015000615 A BR112015000615 A BR 112015000615A BR 112015000615 A8 BR112015000615 A8 BR 112015000615A8
Authority
BR
Brazil
Prior art keywords
treatment
viral infections
pharmaceutical composition
macrocyclic
purines
Prior art date
Application number
BR112015000615A
Other languages
English (en)
Other versions
BR112015000615A2 (pt
BR112015000615B1 (pt
Inventor
Pierre Alexandre Arnoult Eric
Marc Maurice Doublet Frédéric
Jean-François Bonfanti
Michel Claude Fortin Jérôme
Philippe Muller
Jean-Marie Bernard Raboisson Pierre
Original Assignee
Janssen R&D Ireland
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen R&D Ireland, Janssen Sciences Ireland Uc filed Critical Janssen R&D Ireland
Publication of BR112015000615A2 publication Critical patent/BR112015000615A2/pt
Publication of BR112015000615A8 publication Critical patent/BR112015000615A8/pt
Publication of BR112015000615B1 publication Critical patent/BR112015000615B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

purinas macrocíclicas para o tratamento de infecções virais. a presente invenção refere-se aos derivados purínicos macrocíclicos apresentando fórmula (i) processos para sua preparação, composições farmacêuticas, e seu uso no tratamento de infecções virais.
BR112015000615-9A 2012-07-13 2013-07-12 Purinas macrocíclicas para o tratamento de infecções virais e composição farmacêutica que as compreende BR112015000615B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12176330 2012-07-13
EP12176330.4 2012-07-13
PCT/EP2013/064763 WO2014009509A1 (en) 2012-07-13 2013-07-12 Macrocyclic purines for the treatment of viral infections

Publications (3)

Publication Number Publication Date
BR112015000615A2 BR112015000615A2 (pt) 2017-06-27
BR112015000615A8 true BR112015000615A8 (pt) 2021-10-19
BR112015000615B1 BR112015000615B1 (pt) 2022-05-31

Family

ID=48782357

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015000615-9A BR112015000615B1 (pt) 2012-07-13 2013-07-12 Purinas macrocíclicas para o tratamento de infecções virais e composição farmacêutica que as compreende

Country Status (29)

Country Link
US (2) US10280180B2 (pt)
EP (1) EP2872515B1 (pt)
JP (1) JP6250046B2 (pt)
KR (1) KR102207888B1 (pt)
CN (1) CN104703990B (pt)
AU (1) AU2013288600B2 (pt)
BR (1) BR112015000615B1 (pt)
CA (1) CA2874800C (pt)
CL (1) CL2015000080A1 (pt)
CY (1) CY1117971T1 (pt)
DK (1) DK2872515T3 (pt)
EA (1) EA035790B1 (pt)
ES (1) ES2590508T3 (pt)
HK (1) HK1207062A1 (pt)
HR (1) HRP20161125T1 (pt)
HU (1) HUE030685T2 (pt)
IL (1) IL235990B (pt)
LT (1) LT2872515T (pt)
MX (1) MX360718B (pt)
MY (1) MY167797A (pt)
NZ (1) NZ702364A (pt)
PH (1) PH12015500073A1 (pt)
PL (1) PL2872515T3 (pt)
PT (1) PT2872515T (pt)
SG (1) SG11201408542VA (pt)
SI (1) SI2872515T1 (pt)
UA (1) UA113651C2 (pt)
WO (1) WO2014009509A1 (pt)
ZA (1) ZA201500186B (pt)

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LT2872515T (lt) 2012-07-13 2016-10-10 Janssen Sciences Ireland Uc Makrocikliniai purinai, skirti virusinių infekcijų gydymui
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US9663474B2 (en) 2012-11-16 2017-05-30 Janssen Sciences Ireland Uc Heterocyclic substituted 2-amino quinazoline derivatives for the treatment of viral infections
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