EA201491180A1 - 4'-азидо,3'-фторзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк вируса гепатита с - Google Patents

4'-азидо,3'-фторзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк вируса гепатита с

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Publication number
EA201491180A1
EA201491180A1 EA201491180A EA201491180A EA201491180A1 EA 201491180 A1 EA201491180 A1 EA 201491180A1 EA 201491180 A EA201491180 A EA 201491180A EA 201491180 A EA201491180 A EA 201491180A EA 201491180 A1 EA201491180 A1 EA 201491180A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nucleosides
azido
replication
virus
inhibitors
Prior art date
Application number
EA201491180A
Other languages
English (en)
Other versions
EA024847B1 (ru
Inventor
Марк Смит
Франсиско Ксавьер Таламас
Цзин Чжан
Чжумин ЧЖАН
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of EA201491180A1 publication Critical patent/EA201491180A1/ru
Publication of EA024847B1 publication Critical patent/EA024847B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Настоящее изобретение относится к применению нуклеозидных производных формулы Iгде символы имеют значения, определенные в описании, и их фармацевтически приемлемых солей, а также к фармацевтическим композициям, содержащим такие соединения.
EA201491180A 2011-12-20 2012-12-17 4'-азидо,3'-фторзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк вируса гепатита с EA024847B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161577712P 2011-12-20 2011-12-20
PCT/EP2012/075688 WO2013092447A1 (en) 2011-12-20 2012-12-17 4'-azido, 3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication

Publications (2)

Publication Number Publication Date
EA201491180A1 true EA201491180A1 (ru) 2014-11-28
EA024847B1 EA024847B1 (ru) 2016-10-31

Family

ID=47469968

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491180A EA024847B1 (ru) 2011-12-20 2012-12-17 4'-азидо,3'-фторзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк вируса гепатита с

Country Status (31)

Country Link
US (1) US9708357B2 (ru)
EP (1) EP2794628B1 (ru)
JP (1) JP6118336B2 (ru)
KR (1) KR101687084B1 (ru)
CN (2) CN108409820A (ru)
AU (1) AU2012357986B2 (ru)
BR (1) BR112014015066A2 (ru)
CA (1) CA2869317C (ru)
CL (1) CL2014001599A1 (ru)
CO (1) CO6990719A2 (ru)
CR (1) CR20140255A (ru)
CY (1) CY1119015T1 (ru)
DK (1) DK2794628T3 (ru)
EA (1) EA024847B1 (ru)
ES (1) ES2626484T3 (ru)
HK (2) HK1199037A1 (ru)
HU (1) HUE033332T2 (ru)
IL (1) IL232843B (ru)
IN (1) IN2014CN04530A (ru)
LT (1) LT2794628T (ru)
MA (1) MA35749B1 (ru)
MX (1) MX350810B (ru)
PE (1) PE20141599A1 (ru)
PH (1) PH12014501283A1 (ru)
PL (1) PL2794628T3 (ru)
PT (1) PT2794628T (ru)
SG (1) SG11201403086YA (ru)
SI (1) SI2794628T1 (ru)
UA (1) UA110428C2 (ru)
WO (1) WO2013092447A1 (ru)
ZA (1) ZA201404444B (ru)

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JP2015500851A (ja) 2015-01-08
IL232843A0 (en) 2014-07-31
SG11201403086YA (en) 2014-07-30
ZA201404444B (en) 2015-08-26
MX2014007028A (es) 2014-09-16
ES2626484T3 (es) 2017-07-25
MX350810B (es) 2017-09-20
AU2012357986A1 (en) 2014-06-19
CY1119015T1 (el) 2018-01-10
HK1200835A1 (en) 2015-08-14
CR20140255A (es) 2014-08-20
DK2794628T3 (en) 2017-07-10
IN2014CN04530A (ru) 2015-09-11
US9708357B2 (en) 2017-07-18
HK1199037A1 (en) 2015-06-19
SI2794628T1 (sl) 2017-07-31
WO2013092447A1 (en) 2013-06-27
EP2794628A1 (en) 2014-10-29
EA024847B1 (ru) 2016-10-31
LT2794628T (lt) 2017-07-10
CN108409820A (zh) 2018-08-17
CA2869317C (en) 2016-05-17
HUE033332T2 (en) 2017-11-28
PE20141599A1 (es) 2014-10-30
PT2794628T (pt) 2017-07-05
BR112014015066A2 (pt) 2017-06-13
IL232843B (en) 2018-02-28
PL2794628T3 (pl) 2017-09-29
CO6990719A2 (es) 2014-07-10
JP6118336B2 (ja) 2017-04-19
US20140369959A1 (en) 2014-12-18
KR101687084B1 (ko) 2016-12-15
UA110428C2 (uk) 2015-12-25
CA2869317A1 (en) 2013-06-27
PH12014501283A1 (en) 2014-09-08
KR20140108303A (ko) 2014-09-05
NZ625844A (en) 2016-08-26
CL2014001599A1 (es) 2014-11-03
CN104011060A (zh) 2014-08-27
MA35749B1 (fr) 2014-12-01
EP2794628B1 (en) 2017-03-29
AU2012357986B2 (en) 2017-02-02

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