EA200971074A1 - Антивирусные соединения - Google Patents
Антивирусные соединенияInfo
- Publication number
- EA200971074A1 EA200971074A1 EA200971074A EA200971074A EA200971074A1 EA 200971074 A1 EA200971074 A1 EA 200971074A1 EA 200971074 A EA200971074 A EA 200971074A EA 200971074 A EA200971074 A EA 200971074A EA 200971074 A1 EA200971074 A1 EA 200971074A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- virus
- connections
- compounds
- methods
- administering
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Настоящее изобретение относится к противовирусным соединениям, композициям, содержащим такие соединения, и способам лечения, включающим введение таких соединений, а также к способам получения и промежуточным соединениям, подходящим для получения таких соединений.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93775207P | 2007-06-29 | 2007-06-29 | |
US95969807P | 2007-07-16 | 2007-07-16 | |
PCT/US2008/007928 WO2009005677A2 (en) | 2007-06-29 | 2008-06-26 | Antiviral compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200971074A1 true EA200971074A1 (ru) | 2010-08-30 |
Family
ID=40202103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200971074A EA200971074A1 (ru) | 2007-06-29 | 2008-06-26 | Антивирусные соединения |
Country Status (19)
Country | Link |
---|---|
US (2) | US8513186B2 (ru) |
EP (1) | EP2162432A2 (ru) |
JP (2) | JP5465667B2 (ru) |
KR (1) | KR20100038417A (ru) |
CN (1) | CN101801925A (ru) |
AP (1) | AP2009005073A0 (ru) |
AR (1) | AR068794A1 (ru) |
AU (1) | AU2008271117B2 (ru) |
BR (1) | BRPI0813733A2 (ru) |
CA (1) | CA2692145C (ru) |
CO (1) | CO6251241A2 (ru) |
EA (1) | EA200971074A1 (ru) |
EC (1) | ECSP109906A (ru) |
IL (1) | IL202623A0 (ru) |
MX (1) | MX2009013830A (ru) |
SG (1) | SG182979A1 (ru) |
TW (1) | TW200914013A (ru) |
WO (1) | WO2009005677A2 (ru) |
ZA (1) | ZA201000614B (ru) |
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MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
KR20090024834A (ko) | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규 억제제 |
JP5574982B2 (ja) * | 2008-02-04 | 2014-08-20 | イデニク プハルマセウティカルス,インコーポレイテッド | 大環状セリンプロテアーゼ阻害剤 |
US20090285773A1 (en) * | 2008-05-15 | 2009-11-19 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
MX2011002602A (es) | 2008-09-17 | 2011-04-07 | Boehringer Ingelheim Int | Combinacion de inhibidor de la proteasa ns3 de hcv con interferon y ribavirina. |
CA2737958A1 (en) * | 2008-09-23 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor compounds |
CA2747636A1 (en) * | 2008-12-19 | 2010-07-15 | Gilead Sciences, Inc. | Hcv ns3 protease inhibitors |
EP2393493A4 (en) * | 2009-01-30 | 2013-07-17 | Glaxosmithkline Llc | LINKS |
JP2012520891A (ja) * | 2009-03-19 | 2012-09-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | スルホニルキノリンの製造方法 |
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JP2013501068A (ja) | 2009-08-05 | 2013-01-10 | アイディニックス ファーマシューティカルズ インコーポレイテッド | 大環状セリンプロテアーゼ阻害剤 |
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EP2654900A1 (en) | 2010-12-20 | 2013-10-30 | Gilead Sciences, Inc. | Combinations for treating hcv |
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JP2015533124A (ja) | 2012-10-08 | 2015-11-19 | アッヴィ・インコーポレイテッド | Hcvプロテアーゼ阻害剤を作製するのに有用な化合物 |
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-
2008
- 2008-06-26 JP JP2010514802A patent/JP5465667B2/ja not_active Expired - Fee Related
- 2008-06-26 TW TW097123925A patent/TW200914013A/zh unknown
- 2008-06-26 EP EP08779772A patent/EP2162432A2/en not_active Withdrawn
- 2008-06-26 KR KR1020107002261A patent/KR20100038417A/ko not_active Application Discontinuation
- 2008-06-26 AR ARP080102758A patent/AR068794A1/es not_active Application Discontinuation
- 2008-06-26 US US12/215,601 patent/US8513186B2/en active Active
- 2008-06-26 EA EA200971074A patent/EA200971074A1/ru unknown
- 2008-06-26 CN CN200880104330A patent/CN101801925A/zh active Pending
- 2008-06-26 CA CA2692145A patent/CA2692145C/en not_active Expired - Fee Related
- 2008-06-26 AP AP2009005073A patent/AP2009005073A0/en unknown
- 2008-06-26 WO PCT/US2008/007928 patent/WO2009005677A2/en active Application Filing
- 2008-06-26 BR BRPI0813733-1A patent/BRPI0813733A2/pt not_active IP Right Cessation
- 2008-06-26 SG SG2012048484A patent/SG182979A1/en unknown
- 2008-06-26 AU AU2008271117A patent/AU2008271117B2/en not_active Ceased
- 2008-06-26 MX MX2009013830A patent/MX2009013830A/es not_active Application Discontinuation
-
2009
- 2009-12-09 IL IL202623A patent/IL202623A0/en unknown
- 2009-12-18 CO CO09145303A patent/CO6251241A2/es not_active Application Discontinuation
-
2010
- 2010-01-27 ZA ZA2010/00614A patent/ZA201000614B/en unknown
- 2010-01-28 EC EC2010009906A patent/ECSP109906A/es unknown
-
2013
- 2013-06-13 JP JP2013124380A patent/JP2013177452A/ja not_active Withdrawn
- 2013-07-01 US US13/932,945 patent/US8809267B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US8513186B2 (en) | 2013-08-20 |
US20090186869A1 (en) | 2009-07-23 |
IL202623A0 (en) | 2010-06-30 |
EP2162432A2 (en) | 2010-03-17 |
CO6251241A2 (es) | 2011-02-21 |
BRPI0813733A2 (pt) | 2019-11-05 |
AR068794A1 (es) | 2009-12-09 |
AU2008271117B2 (en) | 2013-10-24 |
CA2692145C (en) | 2015-03-03 |
JP2010532352A (ja) | 2010-10-07 |
ZA201000614B (en) | 2011-11-30 |
AU2008271117A1 (en) | 2009-01-08 |
US8809267B2 (en) | 2014-08-19 |
JP2013177452A (ja) | 2013-09-09 |
WO2009005677A2 (en) | 2009-01-08 |
WO2009005677A3 (en) | 2009-03-05 |
CA2692145A1 (en) | 2009-01-08 |
US20140051626A1 (en) | 2014-02-20 |
JP5465667B2 (ja) | 2014-04-09 |
SG182979A1 (en) | 2012-08-30 |
AP2009005073A0 (en) | 2009-12-31 |
KR20100038417A (ko) | 2010-04-14 |
CN101801925A (zh) | 2010-08-11 |
ECSP109906A (es) | 2010-03-31 |
MX2009013830A (es) | 2010-03-01 |
TW200914013A (en) | 2009-04-01 |
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