DE69213546D1 - Neue Peptid-Verbindungen und Verfahren zur Herstellung davon - Google Patents

Neue Peptid-Verbindungen und Verfahren zur Herstellung davon

Info

Publication number
DE69213546D1
DE69213546D1 DE69213546T DE69213546T DE69213546D1 DE 69213546 D1 DE69213546 D1 DE 69213546D1 DE 69213546 T DE69213546 T DE 69213546T DE 69213546 T DE69213546 T DE 69213546T DE 69213546 D1 DE69213546 D1 DE 69213546D1
Authority
DE
Germany
Prior art keywords
formula
making
methods
peptide compounds
carboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69213546T
Other languages
English (en)
Other versions
DE69213546T2 (de
Inventor
Hisashi Takasugi
Akito Tanaka
Hiroyoshi Sakai
Takatoshi Ishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919110298A external-priority patent/GB9110298D0/en
Priority claimed from GB929202260A external-priority patent/GB9202260D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE69213546D1 publication Critical patent/DE69213546D1/de
Application granted granted Critical
Publication of DE69213546T2 publication Critical patent/DE69213546T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69213546T 1991-05-13 1992-05-08 Neue Peptid-Verbindungen und Verfahren zur Herstellung davon Expired - Fee Related DE69213546T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919110298A GB9110298D0 (en) 1991-05-13 1991-05-13 New peptide compound and a process for the preparation thereof
GB929202260A GB9202260D0 (en) 1992-02-03 1992-02-03 New peptide compound and a process for the preparation thereof

Publications (2)

Publication Number Publication Date
DE69213546D1 true DE69213546D1 (de) 1996-10-17
DE69213546T2 DE69213546T2 (de) 1997-02-27

Family

ID=26298895

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69213546T Expired - Fee Related DE69213546T2 (de) 1991-05-13 1992-05-08 Neue Peptid-Verbindungen und Verfahren zur Herstellung davon

Country Status (15)

Country Link
US (1) US5574016A (de)
EP (1) EP0513675B1 (de)
JP (1) JP2606528B2 (de)
KR (1) KR920021579A (de)
CN (2) CN1043647C (de)
AT (1) ATE142641T1 (de)
AU (1) AU662522B2 (de)
CA (1) CA2068478A1 (de)
DE (1) DE69213546T2 (de)
DK (1) DK0513675T3 (de)
ES (1) ES2091359T3 (de)
GR (1) GR3021182T3 (de)
HU (2) HUT61780A (de)
IL (1) IL101839A (de)
TW (1) TW203057B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272162A (en) * 1992-07-02 1993-12-21 G. D. Searle & Co. Platelet aggregation inhibitors
US5354738A (en) * 1992-09-04 1994-10-11 G. D. Searle & Co. Platelet aggregation inhibitors
US5314902A (en) * 1993-01-27 1994-05-24 Monsanto Company Urea derivatives useful as platelet aggregation inhibitors
DE4309867A1 (de) * 1993-03-26 1994-09-29 Cassella Ag Neue Harnstoffderivate, ihre Herstellung und Verwendung
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
DK0825184T3 (da) * 1993-03-29 2001-09-10 Astrazeneca Ab Heterocykliske derivater som blodpladeaggregeringsinhibitorer
NZ262942A (en) * 1993-03-29 1997-07-27 Zeneca Ltd Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
GB9313285D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Acid derivatives
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
ATE188611T1 (de) * 1993-11-19 2000-01-15 Searle & Co Transdermale zusammensetzung von n-(n-(5-(4- (aminoiminomethyl)phenyl-1-oxopentyl)-l-alpha- aspartyl)-l-phenylalanin oder deren esterderivaten und ihre pharmazeutischverwendbaren salze
US6387880B1 (en) 1994-10-24 2002-05-14 G.D. Searle & Co. Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts
CA2204006A1 (en) * 1994-11-01 1996-05-09 Youko Terajima Tetrahydroisoquinoline derivative and medical preparation containing the same
US5766932A (en) * 1995-12-20 1998-06-16 Hoechst Marion Roussel, Inc. Process for preparing N-acetyl(L)-4-cyanophenylalanine from a mixture of the corresponding D,L ethyl esters using subtilisin
UA48993C2 (uk) * 1995-12-20 2002-09-16 Авентіс Фармасьютікалз, Інк СПОСІБ ОТРИМАННЯ N-АЦЕТИЛ-(L)-4-ЦІАНОФЕНІЛАЛАНІНУ Аc-(L)-Phe(4-CN)-OH І N-АЦЕТИЛ-(L)-П-АМІДИНФЕНІЛАЛАНІН-ЦИКЛОГЕКСИЛГЛІЦИН-<font face="Symbol">b</font>-(3-N-МЕТИЛПІРИДИН)-АЛАНІНУ Аc-(L)-pАph-Сhg-PalMe(3)-NH<sub>2</sub>
JP2001131078A (ja) * 1999-11-09 2001-05-15 Iatron Lab Inc 新規活性固定化血小板及びその製造方法
DE10005631A1 (de) * 2000-02-09 2001-08-23 Max Planck Gesellschaft Arginin-Mimetika als Faktor X¶a¶-Inhibitoren
ES2321693T3 (es) * 2000-09-06 2009-06-10 Emisphere Technologies, Inc. Compuestos de acido cianofenoxi carboxilico y composiciones para la administracion de agentes activos.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
AU646838B2 (en) * 1990-03-09 1994-03-10 F. Hoffmann-La Roche Ag Acetic acid derivatives
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
US5481021A (en) * 1991-03-06 1996-01-02 G. D. Searle & Co. Phenyl amidines derivatives useful as platelet aggregation inhibitors
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
HU211266A9 (en) 1995-11-28
CN1066660A (zh) 1992-12-02
CN1043647C (zh) 1999-06-16
US5574016A (en) 1996-11-12
AU1614492A (en) 1992-11-19
CN1120047A (zh) 1996-04-10
IL101839A0 (en) 1992-12-30
TW203057B (de) 1993-04-01
CA2068478A1 (en) 1992-11-14
KR920021579A (ko) 1992-12-18
HUT61780A (en) 1993-03-01
ATE142641T1 (de) 1996-09-15
JP2606528B2 (ja) 1997-05-07
HU9201578D0 (en) 1992-08-28
EP0513675B1 (de) 1996-09-11
ES2091359T3 (es) 1996-11-01
JPH05148207A (ja) 1993-06-15
GR3021182T3 (en) 1996-12-31
EP0513675A1 (de) 1992-11-19
DE69213546T2 (de) 1997-02-27
DK0513675T3 (da) 1996-09-30
IL101839A (en) 1996-12-05
AU662522B2 (en) 1995-09-07

Similar Documents

Publication Publication Date Title
DE69213546T2 (de) Neue Peptid-Verbindungen und Verfahren zur Herstellung davon
FI906204A (fi) Menetelmä farmaseuttisesti vaikuttavien peptidiyhdisteiden valmistamiseksi
DE69034202D1 (de) Zwischenprodukte zur Herstellung von non-peptiden retroviralproteasehemmenden Verbindungen
DE69413237D1 (en) Plättchenaggregationsinhibitoren
FI930974A (fi) Substituerade aminofosfonatderivat, foerfarande foer framstaellning av desamma och farmaceutiska kompositioner innehaollande desamma
ATE144983T1 (de) Neue tricyclische verbindung oder salze davon, verfahren zur herstellung und antimikrobieller wirkstoff, der sie enthält
FI945975A0 (fi) Haarautuneella aminoryhmällä substituoituja tiatsoleja, menetelmiä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
DE68926981T2 (de) Cephemverbindungen und Verfahren zu ihrer Herstellung
FI935800A0 (fi) Antidepressiva och mot Parkisons sjukdom verksamma foereningar
DE69332366D1 (de) Arylsubstituierte heterocyclische Verbindungen
DE69330601T2 (de) Serotoninergische ergolin derivate
DE69329184D1 (de) Alkylsubstituierte heterocyclische Verbindungen
DE3764918D1 (de) 2,6-piperazin-dion-derivate, ihre verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.
GR3019145T3 (en) Fungicidal furanone derivatives

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee