DK0513675T3 - Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf - Google Patents

Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf

Info

Publication number
DK0513675T3
DK0513675T3 DK92107757.4T DK92107757T DK0513675T3 DK 0513675 T3 DK0513675 T3 DK 0513675T3 DK 92107757 T DK92107757 T DK 92107757T DK 0513675 T3 DK0513675 T3 DK 0513675T3
Authority
DK
Denmark
Prior art keywords
preparation
formula
peptide compound
carboxy
group
Prior art date
Application number
DK92107757.4T
Other languages
Danish (da)
English (en)
Inventor
Akito Tanaka
Hiroyoshi Sakai
Hisashi Takasugi
Takatoshi Ishikawa
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919110298A external-priority patent/GB9110298D0/en
Priority claimed from GB929202260A external-priority patent/GB9202260D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of DK0513675T3 publication Critical patent/DK0513675T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK92107757.4T 1991-05-13 1992-05-08 Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf DK0513675T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919110298A GB9110298D0 (en) 1991-05-13 1991-05-13 New peptide compound and a process for the preparation thereof
GB929202260A GB9202260D0 (en) 1992-02-03 1992-02-03 New peptide compound and a process for the preparation thereof

Publications (1)

Publication Number Publication Date
DK0513675T3 true DK0513675T3 (da) 1996-09-30

Family

ID=26298895

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92107757.4T DK0513675T3 (da) 1991-05-13 1992-05-08 Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf

Country Status (15)

Country Link
US (1) US5574016A (de)
EP (1) EP0513675B1 (de)
JP (1) JP2606528B2 (de)
KR (1) KR920021579A (de)
CN (2) CN1043647C (de)
AT (1) ATE142641T1 (de)
AU (1) AU662522B2 (de)
CA (1) CA2068478A1 (de)
DE (1) DE69213546T2 (de)
DK (1) DK0513675T3 (de)
ES (1) ES2091359T3 (de)
GR (1) GR3021182T3 (de)
HU (2) HUT61780A (de)
IL (1) IL101839A (de)
TW (1) TW203057B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272162A (en) * 1992-07-02 1993-12-21 G. D. Searle & Co. Platelet aggregation inhibitors
US5354738A (en) * 1992-09-04 1994-10-11 G. D. Searle & Co. Platelet aggregation inhibitors
US5314902A (en) * 1993-01-27 1994-05-24 Monsanto Company Urea derivatives useful as platelet aggregation inhibitors
DE4309867A1 (de) * 1993-03-26 1994-09-29 Cassella Ag Neue Harnstoffderivate, ihre Herstellung und Verwendung
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5563141A (en) * 1993-03-29 1996-10-08 Zeneca Limited Heterocyclic compounds
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
EP0825184B1 (de) * 1993-03-29 2001-06-20 AstraZeneca AB Heterozyklische Derivate als Plätchenaggregationsinhibitoren
US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
GB9313285D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Acid derivatives
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
EP0729362B1 (de) * 1993-11-19 2000-01-12 G.D. SEARLE & CO. Transdermale zusammensetzung von n-(n-(5-(4-(aminoiminomethyl)phenyl-1-oxopentyl)-l-alpha-aspartyl)-l-phenylalanin oder deren esterderivaten und ihre pharmazeutischverwendbaren salze
US6387880B1 (en) 1994-10-24 2002-05-14 G.D. Searle & Co. Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts
AU691677B2 (en) * 1994-11-01 1998-05-21 Terumo Kabushiki Kaisha Tetrahydroisoquinoline derivative and medicinal preparation containing the same
PL185541B1 (pl) * 1995-12-20 2003-05-30 Aventis Pharmaceuticals Sposób wytwarzania N-acetylo-(L)-4-cyjanofenyloalaniny i N-acetylo-(L)-p-amidynofenyloalaninocykloheksyloglicyno-beta-(3-N-metylopirydynio)-alaniny
US5766932A (en) * 1995-12-20 1998-06-16 Hoechst Marion Roussel, Inc. Process for preparing N-acetyl(L)-4-cyanophenylalanine from a mixture of the corresponding D,L ethyl esters using subtilisin
JP2001131078A (ja) * 1999-11-09 2001-05-15 Iatron Lab Inc 新規活性固定化血小板及びその製造方法
DE10005631A1 (de) 2000-02-09 2001-08-23 Max Planck Gesellschaft Arginin-Mimetika als Faktor X¶a¶-Inhibitoren
ATE429416T1 (de) * 2000-09-06 2009-05-15 Emisphere Tech Inc Cyanophenoxy-carbonsäuren und zusammensetzungen für die freisetzung aktiver substanzen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
AU646838B2 (en) * 1990-03-09 1994-03-10 F. Hoffmann-La Roche Ag Acetic acid derivatives
ES2065182T3 (es) * 1991-03-06 1995-02-01 Searle & Co Derivados de fenilamidinas utiles como inhibidores de la agregacion de plaquetas.
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
DE69213546D1 (de) 1996-10-17
DE69213546T2 (de) 1997-02-27
CN1066660A (zh) 1992-12-02
HU211266A9 (en) 1995-11-28
EP0513675B1 (de) 1996-09-11
HU9201578D0 (en) 1992-08-28
US5574016A (en) 1996-11-12
KR920021579A (ko) 1992-12-18
CN1043647C (zh) 1999-06-16
CN1120047A (zh) 1996-04-10
TW203057B (de) 1993-04-01
JPH05148207A (ja) 1993-06-15
AU1614492A (en) 1992-11-19
ES2091359T3 (es) 1996-11-01
CA2068478A1 (en) 1992-11-14
HUT61780A (en) 1993-03-01
ATE142641T1 (de) 1996-09-15
JP2606528B2 (ja) 1997-05-07
IL101839A (en) 1996-12-05
IL101839A0 (en) 1992-12-30
AU662522B2 (en) 1995-09-07
GR3021182T3 (en) 1996-12-31
EP0513675A1 (de) 1992-11-19

Similar Documents

Publication Publication Date Title
DK0513675T3 (da) Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf
FI882813A0 (fi) Pyrazolopyridinfoerening och foerfarande foer dess framstaellning.
DE69434136D1 (de) Dolastatin-derivate
DK0622361T3 (da) Heterocykliske forbindelser som bradykininantagonister
DK0467248T3 (da) Pyrazolopyridinforbindelse og fremgangsmåder til fremstilling heraf
GR3023219T3 (en) Pyrazolopyridine compounds and processes for preparation thereof
PT976748E (pt) Derivados de pirrolidina com actividade inibidora de fosfolipase a2
DE69413237D1 (en) Plättchenaggregationsinhibitoren
ES2148254T3 (es) Peptidos antimicrobianos ciclicos y preparacion de los mismos.
HU914153D0 (en) Electrically operated lock
DK0559079T3 (da) Substituerede aminophosphonatderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende derivaterne
CA2140927A1 (en) Platelet aggregation inhibitors
DE68926981D1 (de) Cephemverbindungen und Verfahren zu ihrer Herstellung
DE69332366D1 (de) Arylsubstituierte heterocyclische Verbindungen
DE69329184D1 (de) Alkylsubstituierte heterocyclische Verbindungen
MX9206930A (es) Nuevos compuestos
FI895139A0 (fi) Pyrrolidinderivat.
WO1987004435A3 (en) Xanthine compounds
ES2149180T3 (es) Derivado de pirazolotiazolopirimidina.