ES2055296T3 - Compuestos ciclicos de tricetona y compuestos de trimetilsililoxi butadieno y su uso en la preparacion de derivados de la daunomicinona. - Google Patents
Compuestos ciclicos de tricetona y compuestos de trimetilsililoxi butadieno y su uso en la preparacion de derivados de la daunomicinona.Info
- Publication number
- ES2055296T3 ES2055296T3 ES90200212T ES90200212T ES2055296T3 ES 2055296 T3 ES2055296 T3 ES 2055296T3 ES 90200212 T ES90200212 T ES 90200212T ES 90200212 T ES90200212 T ES 90200212T ES 2055296 T3 ES2055296 T3 ES 2055296T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- compounds
- daunomycinone
- preparation
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- YOFDHOWPGULAQF-MQJDWESPSA-N (7s,9s)-9-acetyl-6,7,9,11-tetrahydroxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical class C1[C@@](O)(C(C)=O)C[C@H](O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O YOFDHOWPGULAQF-MQJDWESPSA-N 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical class C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 title 1
- 150000001923 cyclic compounds Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- YOFDHOWPGULAQF-UHFFFAOYSA-N Daunomycin-Aglycone Natural products C1C(O)(C(C)=O)CC(O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O YOFDHOWPGULAQF-UHFFFAOYSA-N 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
- WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 abstract 1
- 238000005698 Diels-Alder reaction Methods 0.000 abstract 1
- 229940009456 adriamycin Drugs 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
- 150000001993 dienes Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION PROVEE NUEVOS COMPUESTOS DE TRIACETONA CICLICA DE LA FORMULA EN DONDE S ES H, ALQUILO Y R* ES UN GRUPO DE LA FORMULA EN DONDE R1 ES METILO Y R2 ES UN GRUPO ALQUILO CONTENIENDO AL MENOS 2 ATOMOS DE CARBONO, O R1 ES UN GRUPO ALQUILO QUE TIENE DE 1 A 4 ATOMOS DE CARBONO Y R2 ES UN GRUPO ARILO, UN GRUPO HETERO ARILO, UN -CH2OR'', UN GRUPO , UN GRUPO -CH2SR'''' O UN GRUPO -CH2CH=CH2, EN DONDE A'' Y R'''' SON GRUPOS ALQUILO QUE TIENEN DE 1 A 4 ATOMOS DE CARBONO. ESTOS COMPUESTOS SE PUEDEN USAR PARA LA PREPARACION DE DAUNOMICINONA Y SUS DERIVADOS. LA DAUNOMICINONA SE USA PARA PREPARAR DAUNOMICINA Y ADRIAMICINA. INTRODUCIENDO TRIDIMENSIONALIDAD EN EL C-1 DEL ANILLO A EN LA PREPARACION DE DICHOS NUEVOS COMPUESTOS MEDIANTE EL USO DE NUEVOS DIENOS DE FORMULA (1) EN UNA REACCION DE DIELS-ALDER PARA DICHA PREPARACION, SE ESTABLECE LA TRIDIMENSIONALIDAD DEL C-3 EN LA SUBSECUENTE REACCION CON LIC (EQUIVALE) CSI(CH3) EN LA SINTESIS DE DAUNOMICINONA Y DE DERIVADOS DE ELLA. ESTA ULTIMA REACCIONCONDUCE AL COMPUESTO DESEADO EN DONDE OH EN C-3 Y OR EN C-1 ESTAN EN LA POSICION CIS CON RESPECTO A CADA UNO DE LOS OTROS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8900329A NL8900329A (nl) | 1989-02-10 | 1989-02-10 | Cyclische triketonverbindingen en trimethylsilyloxybutadieenverbindingen en hun toepassing bij het bereiden van daunomycinonderivaten. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2055296T3 true ES2055296T3 (es) | 1994-08-16 |
Family
ID=19854110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90200212T Expired - Lifetime ES2055296T3 (es) | 1989-02-10 | 1990-01-29 | Compuestos ciclicos de tricetona y compuestos de trimetilsililoxi butadieno y su uso en la preparacion de derivados de la daunomicinona. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5097051A (es) |
| EP (1) | EP0383372B1 (es) |
| JP (1) | JPH02235836A (es) |
| AT (1) | ATE87901T1 (es) |
| CA (1) | CA2009096A1 (es) |
| DE (1) | DE69001266T2 (es) |
| DK (1) | DK0383372T3 (es) |
| ES (1) | ES2055296T3 (es) |
| NL (1) | NL8900329A (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL9001834A (nl) * | 1990-08-16 | 1992-03-16 | Pharmachemie Bv | Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten. |
| US5416403A (en) * | 1993-02-11 | 1995-05-16 | Hewlett-Packard Corporation | Current stabilizing circuit |
| FR2740772B1 (fr) * | 1995-11-02 | 1998-01-16 | Girex | Procede de preparation d'anthraquinones substituees et application a la preparation de rheines |
| DE102007031461A1 (de) | 2007-07-05 | 2009-01-08 | Sappok, Manfred, Dipl.-Phys. Dr. | Verfahren zum Stabilisieren von Heizöl oder Dieselöl, insbesondere aus der Depolimerisation von kohlenwasserstoffhaltigen Rückständen |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405522A (en) * | 1982-01-18 | 1983-09-20 | Adria Laboratories Inc. | Anthracycline synthesis |
-
1989
- 1989-02-10 NL NL8900329A patent/NL8900329A/nl not_active Application Discontinuation
-
1990
- 1990-01-29 AT AT90200212T patent/ATE87901T1/de not_active IP Right Cessation
- 1990-01-29 EP EP90200212A patent/EP0383372B1/en not_active Expired - Lifetime
- 1990-01-29 ES ES90200212T patent/ES2055296T3/es not_active Expired - Lifetime
- 1990-01-29 DK DK90200212.0T patent/DK0383372T3/da active
- 1990-01-29 DE DE9090200212T patent/DE69001266T2/de not_active Expired - Fee Related
- 1990-02-01 CA CA002009096A patent/CA2009096A1/en not_active Abandoned
- 1990-02-01 US US07/473,538 patent/US5097051A/en not_active Expired - Fee Related
- 1990-02-03 JP JP2024987A patent/JPH02235836A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NL8900329A (nl) | 1990-09-03 |
| DE69001266T2 (de) | 1993-09-16 |
| JPH02235836A (ja) | 1990-09-18 |
| CA2009096A1 (en) | 1990-08-10 |
| DK0383372T3 (da) | 1993-08-02 |
| DE69001266D1 (de) | 1993-05-13 |
| EP0383372B1 (en) | 1993-04-07 |
| US5097051A (en) | 1992-03-17 |
| EP0383372A1 (en) | 1990-08-22 |
| ATE87901T1 (de) | 1993-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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