DE69001266D1 - Cyclische triketonverbindungen und trimethylsilylbutadienverbindungen und ihre verwendung zur herstellung von daunomycinon-derivaten. - Google Patents
Cyclische triketonverbindungen und trimethylsilylbutadienverbindungen und ihre verwendung zur herstellung von daunomycinon-derivaten.Info
- Publication number
- DE69001266D1 DE69001266D1 DE9090200212T DE69001266T DE69001266D1 DE 69001266 D1 DE69001266 D1 DE 69001266D1 DE 9090200212 T DE9090200212 T DE 9090200212T DE 69001266 T DE69001266 T DE 69001266T DE 69001266 D1 DE69001266 D1 DE 69001266D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- group
- daunomycinone
- derivatives
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- YOFDHOWPGULAQF-MQJDWESPSA-N (7s,9s)-9-acetyl-6,7,9,11-tetrahydroxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical class C1[C@@](O)(C(C)=O)C[C@H](O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O YOFDHOWPGULAQF-MQJDWESPSA-N 0.000 title abstract 4
- YFSJFUCGCAQAJA-UHFFFAOYSA-N buta-1,3-dienyl(trimethyl)silane Chemical class C[Si](C)(C)C=CC=C YFSJFUCGCAQAJA-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- YOFDHOWPGULAQF-UHFFFAOYSA-N Daunomycin-Aglycone Natural products C1C(O)(C(C)=O)CC(O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O YOFDHOWPGULAQF-UHFFFAOYSA-N 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
- WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 abstract 1
- 238000005698 Diels-Alder reaction Methods 0.000 abstract 1
- 229940009456 adriamycin Drugs 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
- 150000001993 dienes Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8900329A NL8900329A (nl) | 1989-02-10 | 1989-02-10 | Cyclische triketonverbindingen en trimethylsilyloxybutadieenverbindingen en hun toepassing bij het bereiden van daunomycinonderivaten. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69001266D1 true DE69001266D1 (de) | 1993-05-13 |
| DE69001266T2 DE69001266T2 (de) | 1993-09-16 |
Family
ID=19854110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE9090200212T Expired - Fee Related DE69001266T2 (de) | 1989-02-10 | 1990-01-29 | Cyclische triketonverbindungen und trimethylsilylbutadienverbindungen und ihre verwendung zur herstellung von daunomycinon-derivaten. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5097051A (de) |
| EP (1) | EP0383372B1 (de) |
| JP (1) | JPH02235836A (de) |
| AT (1) | ATE87901T1 (de) |
| CA (1) | CA2009096A1 (de) |
| DE (1) | DE69001266T2 (de) |
| DK (1) | DK0383372T3 (de) |
| ES (1) | ES2055296T3 (de) |
| NL (1) | NL8900329A (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL9001834A (nl) * | 1990-08-16 | 1992-03-16 | Pharmachemie Bv | Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten. |
| US5416403A (en) * | 1993-02-11 | 1995-05-16 | Hewlett-Packard Corporation | Current stabilizing circuit |
| FR2740772B1 (fr) * | 1995-11-02 | 1998-01-16 | Girex | Procede de preparation d'anthraquinones substituees et application a la preparation de rheines |
| DE102007031461A1 (de) | 2007-07-05 | 2009-01-08 | Sappok, Manfred, Dipl.-Phys. Dr. | Verfahren zum Stabilisieren von Heizöl oder Dieselöl, insbesondere aus der Depolimerisation von kohlenwasserstoffhaltigen Rückständen |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405522A (en) * | 1982-01-18 | 1983-09-20 | Adria Laboratories Inc. | Anthracycline synthesis |
-
1989
- 1989-02-10 NL NL8900329A patent/NL8900329A/nl not_active Application Discontinuation
-
1990
- 1990-01-29 AT AT90200212T patent/ATE87901T1/de not_active IP Right Cessation
- 1990-01-29 ES ES90200212T patent/ES2055296T3/es not_active Expired - Lifetime
- 1990-01-29 DE DE9090200212T patent/DE69001266T2/de not_active Expired - Fee Related
- 1990-01-29 EP EP90200212A patent/EP0383372B1/de not_active Expired - Lifetime
- 1990-01-29 DK DK90200212.0T patent/DK0383372T3/da active
- 1990-02-01 US US07/473,538 patent/US5097051A/en not_active Expired - Fee Related
- 1990-02-01 CA CA002009096A patent/CA2009096A1/en not_active Abandoned
- 1990-02-03 JP JP2024987A patent/JPH02235836A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2009096A1 (en) | 1990-08-10 |
| US5097051A (en) | 1992-03-17 |
| DE69001266T2 (de) | 1993-09-16 |
| EP0383372A1 (de) | 1990-08-22 |
| EP0383372B1 (de) | 1993-04-07 |
| ES2055296T3 (es) | 1994-08-16 |
| ATE87901T1 (de) | 1993-04-15 |
| NL8900329A (nl) | 1990-09-03 |
| JPH02235836A (ja) | 1990-09-18 |
| DK0383372T3 (da) | 1993-08-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lin et al. | Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study. | |
| DE69332577D1 (de) | Verfahren zur Herstellung von 13-Ether-Derivaten von Milbemycinen und Zwischenprodukte | |
| GB8919434D0 (en) | Novel compounds | |
| DE69120500D1 (de) | Azasteroide zur Behandlung prostatischer Hypertrophie, ihre Herstellung und Verwendung | |
| ATE143954T1 (de) | Verfahren zur herstellung von pyranonen und pyrandionen | |
| DE3767351D1 (de) | Sialosylceramide und verfahren zu deren herstellung. | |
| DE2962235D1 (en) | 2'-deoxy-5-fluorouridine derivatives, a process for producing the same and antitumor agents comprising the same | |
| ATE118523T1 (de) | Flüssigkristall-racematmischung, flüssigkristallzusammensetzung und flüssigkristallelement, verfahren zur herstellung und verwendung. | |
| RU94045799A (ru) | СПОСОБ ПОЛУЧЕНИЯ β-ФЕНИЛИЗОСЕРИНА И ЕГО АНАЛОГОВ, СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ТАКСАНА И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ СИНТЕЗА | |
| DE69001266D1 (de) | Cyclische triketonverbindungen und trimethylsilylbutadienverbindungen und ihre verwendung zur herstellung von daunomycinon-derivaten. | |
| ATE222238T1 (de) | Verfahren und zwischenprodukte zur herstellung von piperazinderivaten | |
| ES482075A1 (es) | Procedimiento para la preparacion de carbonilaminofenoxilicosustituidos con biciclo -3.1.0-hexilo. | |
| GB1564808A (en) | 23,24-epoxy-25-hydroxycholestane derivatives | |
| ES8701174A1 (es) | Un metodo de preparacion de un compuesto de tiadiazina | |
| KR890008156A (ko) | 깅콜리드의 신규 알콜시 유도체, 그 제조 방법 및 이를 함유한 치료 조성물 | |
| KR890009901A (ko) | 3-히드록시-2-(4-메톡시페닐)-5-(2-메틸아미노에틸)-2,3-디히드로-5h-1,5- 벤조티아제핀-4-온 유도체, 그의 제조 및 치료에의 이용 | |
| DE59009525D1 (de) | Herstellung von Isochinolinderivaten. | |
| KR910016659A (ko) | 키랄 나프탈린디카복실레이트 | |
| IL83164A (en) | Pharmaceutical compositions containing 2,3-dihydro-5-(hetero)aryl-imidazo(2,1-a)isoquinolines,some new such compounds and their preparation | |
| DE69800073D1 (de) | Verfahren zur Herstellung von 2-Cyanobiphenyl-Verbindungen | |
| DE68909143D1 (de) | Prostaglandin-Vorläufer und ihre Herstellung. | |
| DE69008396D1 (de) | Trimethylsilylacetylenverbindungen, ihre Herstellung und ihre Verwendung zur Herstellung von Daunomycinon-Derivaten. | |
| ES2007116A6 (es) | Un procedimiento para la preparacion de derivados de hidantoina c-5 etilenicamente instaurados. | |
| HUT50833A (en) | Process for producing indolo/3,2-1-de/ /1,4/-oxazino/2,3,4-ij/ /1,5/-naphthyridine derivatives | |
| DE3473269D1 (en) | (bis(substituted methyl)-methyl)-isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |